Article
Biochemistry & Molecular Biology
Zhi Nie, Dating Cheng, Chenglong Pan, Zhimin Wei, Chenyang Wang, Chunyan Wang
Summary: The study revealed that SH3BGRL3 is highly expressed in GBM and glioma stem cells, and its high expression is associated with poor survival in GBM patients. SH3BGRL3 is directly regulated by STAT3, forming a positive feedback loop that enhances the tumorigenic potential of GBM.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Jingjing Ma, Qiong Shi, Sen Guo, Peng Xu, Xiuli Yi, Yuqi Yang, Weigang Zhang, Yu Liu, Lin Liu, Qiao Yue, Tao Zhao, Tianwen Gao, Weinan Guo, Chunying Li
Summary: This study explored the expression profile and role of long non-coding RNAs (lncRNAs) in melanoma progression. Through microarray analysis, differentially-expressed lncRNAs in primary melanomas compared with nevus were identified. Bioinformatics analysis revealed the involvement of dysregulated lncRNAs in melanoma biology and immune response. CD27-AS1-208, a novel nuclear-localized lncRNA, was found to facilitate melanoma cell proliferation, invasion, and migration by interacting with STAT3. The up-regulation of CD27-AS1-208 was shown to contribute to melanoma progression by activating the STAT3 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Hao-Nan Li, Qing-Qing Yang, Wen-Tao Wang, Xue Tian, Fan Feng, Shu-Ting Zhang, Yu-Tong Xia, Jia-Xue Wang, Yuan-Wu Zou, Jun-Yang Wang, Xiao-Yan Zeng
Summary: The red nucleus IL-33 plays a role in the early development of mononeuropathic pain by activating multiple signaling pathways to promote pain effects. The study results suggest that red nucleus IL-33 is involved in the development of mononeuropathic pain by regulating cytokine expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Huanhuan Ma, Fengqiong Zhang, Lin Zhou, Tingyan Cao, Dachao Sun, Shixiong Wen, Jinpei Zhu, Zhaoqianyu Xiong, Ming-Tong Tsau, Mei-Ling Cheng, Li-Man Hung, Yanming Zhou, Qinxi Li
Summary: The study reveals that tyrosine kinase c-Src phosphorylates G6PD to enhance its catalytic activity, promoting PPP flux in cancer cells and contributing to tumorigenesis. This uncovers a new aspect of c-Src in cell proliferation and tumorigenesis, deepening our understanding of c-Src as a proto-oncogene.
Article
Plant Sciences
Jian Song, Di Zhao, Guozhu Sun, Jiankai Yang, Zhongqiang Lv, Baohua Jiao
Summary: The phosphorylation of STAT3 is up-regulated and regulated by PTPRM in GBM cells, while FN1 is also reported to be up-regulated in GBM. Overexpressing PTPRM inhibits STAT3 phosphorylation, interfering with PTPRM increases colony numbers in GBM cells. Overexpressing FN1 decreases PTPRM levels, while knockdown of FN1 inhibits PTPRM methylation and STAT3 phosphorylation.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kan Zhang, Weiqi Yin, Luping Ma, Zhili Liu, Qiang Li
Summary: This study found that HSPB8 is abundantly expressed in prostate cancer tissues and cells, and promotes the malignant characteristics of the disease by activating the Janus kinase/STAT3 signaling pathway. These results suggest that HSPB8 may be a potential therapeutic target for prostate cancer patients.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Oncology
Yi Zhao, Zhansheng Hu, Jincheng Li, Tingyan Hu
Summary: EZH2 exacerbates breast cancer by methylating STAT3 directly, providing a promising therapeutic target for breast cancer.
Article
Immunology
Decai Wang, Fan Wang, Yu Huang, Jianjun Wang, Huiwen Luo, Pu Zhang, Jingtao Peng, Gang Tang, Yaodong Wang, Li Yu, Dong Ni
Summary: This study found that TSLP and TSLPR were highly expressed in hydronephrotic tissues of humans and mice, with TSLP mainly expressed in renal tubular cells and TSLPR co-localized with α-SMA in fibroblasts. Knocking out TSLPR in the UUO model reduced the severity of renal fibrosis, and antibody blockade of TSLP also decreased fibrosis levels. Functional analysis revealed that hypoxic exposure induced overexpression of TSLP in renal tubular cells through HIF-1α, and tubular cell-derived TSLP activated fibroblasts by binding to TSLPR in a paracrine manner. The HIF-1α/TSLP/TSLPR and STAT3 signaling pathways were found to be involved in the activation and proliferation of kidney fibroblasts, suggesting their potential as therapeutic targets for renal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xu Wu, Hui Zhang, Gang Jiang, Minlian Peng, Cheng Li, Jiaxin Lu, Shiyin Jiang, Xiaoping Yang, Yongliang Jiang
Summary: The transfer process of S100A4 between cells and its impact on the development of non-small cell lung cancer (NSCLC) by affecting STAT3 expression were studied. It was found that exosome-transmitted S100A4 promotes NSCLC progression by activating STAT3 pathway and inhibiting T-cell immune activity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinpeng Du, Wenwei Liao, Haichuan Wang, Guimin Hou, Min Liao, Lin Xu, Jiwei Huang, Kefei Yuan, Xiangzheng Chen, Yong Zeng
Summary: This study demonstrates the essential role of MDIG in liver regeneration by regulating histone methylation to alter chromatin accessibility. MDIG deficiency results in impaired liver regeneration and delayed cell cycle progression, and it is found that MDIG regulates Myc by modifying chromatin accessibility.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei, Xingguo Liu, Keshi Chen
Summary: The study revealed that Mkk6 acts as a chromatin relaxer during reprogramming by promoting histone acetylation levels and facilitating transcription factor binding, ultimately enhancing pluripotency gene expression.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Food Science & Technology
Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng
Summary: FFA2 might contribute to cardiac hypertrophy by activating STAT3 and GATA4 via ERK1/2, providing a potential new target for therapy.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biotechnology & Applied Microbiology
Jie Xiong, Xingyi Kuang, Tingting Lu, Kunlin Yu, Xu Liu, Zhaoyuan Zhang, Weili Wang, Lu Zhao, Qin Fang, Depei Wu, Jishi Wang
Summary: The study demonstrates that levels of C3a and C5a are elevated in MM patients and their receptors are highly expressed on myeloma cells. These anaphylatoxins promote migration, invasion, and adhesion of MM cells through MEK/ERK pathway activation and Nrf2 nuclear translocation. Nrf2 downregulation could attenuate the migration of C3a and C5a-stimulated MM cells in vivo, suggesting potential therapeutic targets for MM treatment.
CANCER GENE THERAPY
(2021)
Article
Oncology
Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Jia Li, Zhiqiang Hu, Haoyang Xin, Chubin Luo, Jian Zhou, Jia Fan, Shaolai Zhou
Summary: The interaction between TANs and TAMs enhances the proliferation and invasion abilities of ICC cells, promoting ICC progression. They can produce Oncostatin M and interleukin-11 in co-culture, activating STAT3 signaling in ICC cells, and silencing STAT3 can disrupt the pro-tumor effect of TANs and TAMs on ICC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xin Zhang, Hongwei Zhang, Zhibin Liao, Jiacheng Zhang, Huifang Liang, Weixing Wang, Jia Yu, Keshuai Dong
Summary: This study reveals that SHC4 activates STAT3 signaling to promote hepatocellular carcinoma (HCC) progression. SHC4 overexpression in HCC is associated with poor prognosis, increased migration and invasion. SHC4 enhances cell proliferation, colony formation, migration, and invasion, as well as cell cycle progression and epithelial-mesenchymal transition (EMT) in HCC cells. Additionally, the activation of STAT3 signaling is observed in SHC4 overexpressed HCC cells and tissues. Moreover, intervention of STAT3 confirms its importance in the oncogenic role of SHC4 in HCC.
CANCER CELL INTERNATIONAL
(2022)