Article
Biochemistry & Molecular Biology
Minh Huynh, Derek Parsonage, Tom E. Forshaw, Venkat R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. Poole, Sharon L. Campbell
Summary: The recent development of mutant-selective inhibitors for the oncogenic KRAS(G12C) allele has generated excitement. These inhibitors covalently engage the mutant C12 thiol, locking the KRAS(G12C) protein in an inactive state. However, there are still mechanistic questions regarding the reactivity of this thiol.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sarah M. Rehn, Theodor M. Gerrard-Anderson, Yu Chen, Peng Wang, Timothy Robertson, Thomas P. Senftle, Matthew R. Jones
Summary: The influence of organic surface chemistry on the properties and mechanical behavior of inorganic nanomaterials is not well understood. This study demonstrates that the mechanical strength of a silver nanoplate can be controlled by the binding enthalpy of its surface ligands. The results show a size-dependent coupling between chemistry and mechanics at the nanoscale, with surface ligands affecting the plastic deformation and global mechanical strength of the nanoplate.
Article
Chemistry, Multidisciplinary
Sarah M. Rehn, Theodor M. Gerrard-Anderson, Yu Chen, Peng Wang, Timothy Robertson, Thomas P. Senftle, Matthew R. Jones
Summary: Inorganic nanomaterials can be influenced by organic surface chemistry, which can modulate the mechanical strength of silver nanoplates. A continuum-based core-shell model reveals that the interior of the nanoplate retains bulk-like properties, while the surface shell has yield strength values determined by surface chemistry. Electron diffraction experiments show lattice expansion and disordering of atoms at the nanoplate surface, which are directly related to the coordinating strength of the surface ligands.
Article
Chemistry, Medicinal
Geeta Kumari, Devasahayam Arokia Balaya Rex, Sangam Goswami, Soumyadeep Mukherjee, Shreeja Biswas, Preeti Maurya, Ravi Jain, Swati Garg, Thottethodi Subrahmanya Keshava Prasad, Soumya Pati, Sivaprakash Ramalingam, Narla Mohandas, Shailja Singh
Summary: Phosphorylation and other post-translational modifications play an important role in the palmitoylation of red blood cell proteins and their involvement in parasite invasion.
ACS INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Jeeho Kim, Young Jin Jeon, Sung-Chul Lim, Joohyun Ryu, Jung-Hee Lee, In-Youb Chang, Ho Jin You
Summary: Ephexin1 is highly expressed in patient tissues of colorectal cancer (CRC) and lung cancer (LC), and plays a critical role in promoting tumorigenesis through the Ras-mediated signaling pathway. Phosphorylated Ephexin1 at Ser16 and Ser18 (pSer16/18) may serve as an effective therapeutic target for CRC and LC as it interacts with oncogenic K-Ras to promote downstream MAPK signaling.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Soham Mukhopadhyay, Subhas C. Bera, Kabir Ramola
Summary: In this paper, the authors analyzed images of growing amyloid fibrils obtained from total internal reflection fluorescence microscopy using fractal geometry. They found evidence supporting a two-step aggregation kinetics for amyloid-beta proteins, with an initial linear elongation phase followed by branching.
Article
Multidisciplinary Sciences
Li-Ting Wang, Marie-Eve Proulx, Anne D. Kim, Virginie Lelarge, Luke McCaffrey
Summary: Proteomics-based screening identified proteins associated with lumen formation, including PARD3B, RALB, and HRNR. Functional analyses revealed their roles as regulators of lumen formation. Additionally, PTPN14 was identified as a component required for maintaining apical-basal polarity.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Senjuti Chakraborty, Siddhant Jaitpal, Sourav Acharya, Debjani Paul
Summary: One of the key factors in biosensor design is having an effective capture layer. Surface-immobilized proteins, particularly antibody-antigen combinations, are commonly used as capture ligands in flow-based biosensors. The surface coverage of these proteins can be influenced by the linker chemistry and microchannel geometry. In this study, we compared the effectiveness of different linkers (glutaraldehyde, EDC-NHS, sulfo-SMCC, sulfo-NHS-biotin) in straight, serpentine, and square-wave microchannel geometries using streptavidin as a model protein. We found that straight microchannels achieved the highest level of protein immobilization, regardless of the linker chemistry used. Moreover, sulfo-NHS-biotin showed the highest immobilization of streptavidin among all the linkers for each microchannel geometry.
JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valentina Buffa, Giorgia Adamo, Sabrina Picciotto, Antonella Bongiovanni, Daniele P. Romancino
Summary: Protein S-palmitoylation is a reversible lipid modification involving the addition of palmitic acid to cysteine residues. It plays various roles in cellular processes and is associated with diseases. This study presents an optimized method using Acyl Biotin Exchange (ABE) chemistry to detect protein palmitoylation. The resulting protocol is more sensitive and reproducible than the conventional approach.
Review
Biochemistry & Molecular Biology
Alexey Bondar, Josef Lazar
Summary: Heterotrimeric G proteins play a central role in cellular signal transduction by mediating signals from G protein-coupled receptors to downstream effectors. Various optical sensors for G protein localization and function have been developed and applied in living systems since their discovery. This minireview provides an overview of existing G protein-based sensors, experimental approaches, recent advances, challenges, and future directions in the field of G protein sensor development.
Article
Biology
Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu
Summary: Structural analysis of GMPPNP-bound KRAS(G13D) reveals an intermediate state with a new pocket, providing an opportunity for developing targeted therapies against KRAS(G13D)-driven cancers. Dynamics of RAS, including distal regions, is important for understanding its interactions with effectors and designing inhibitors. Methyl relaxation dispersion experiments show synchronized conformational dynamics in active KRAS(G13D), suggesting an exchange between two states. Residual dipolar couplings and crystal structures confirm the presence of an intermediate state distinct from known conformations.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Satoshi Yamaguchi, Kazuho Yamamoto, Ryotaro Yamamoto, Satoshi Takamori, Akira Ishiwatari, Kosuke Minamihata, Teruyuki Nagamune, Akimitsu Okamoto
Summary: In this study, a method for photoactivating intracellular proteins using sterically bulky caging was developed. This method utilized a photocleavable linker to modify the protein of interest with biotin, which was then conjugated with streptavidin to inactivate the protein. The caged protein could be transduced into cells and reactivated through light-induced degradation of the conjugates. This method successfully achieved control of cytotoxic activity, selectively inducing cell death at specific locations using light. It is a simple and versatile tool for studying spatio-temporal cellular events related to intracellular proteins of interest.
Article
Biochemistry & Molecular Biology
Angelo Felline, Francesco Raimondi, Sara Gentile, Francesca Fanelli
Summary: Ras GTPases function as molecular switches, cycling between OFF and ON states depending on the bound nucleotide. The Rab GTPase Sec4p plays regulatory roles in intracellular vesicle trafficking. This study integrated structural information with molecular dynamics simulations to investigate the dynamics of Sec2p and Sec4p, as well as the chain of structural deformations leading to GEF-assisted activation of the Rab GTPase.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Zongyan Jiang, Anbing Shi
Summary: After endocytosis, various cargos are sorted and directed to different destinations, with Rab GTPases playing a major regulatory role in ensuring proper delivery.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Raksha Devi, Laurence Pelletier, Suzanna L. Prosser
Summary: The centrosome, primary cilium, and centriolar satellites play critical roles in cellular processes and are linked to a variety of human diseases. Understanding the molecular mechanisms underlying these diseases requires studying the biology of these organelles. Technological breakthroughs have provided unprecedented spatial and temporal resolution in dissecting the molecular players of these enigmatic organelles.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Article
Biology
Michael Bucher, Stephan Niebling, Yuhao Han, Dmitry Molodenskiy, Fatemeh Hassani Nia, Hans-Juergen Kreienkamp, Dmitri Svergun, Eunjoon Kim, Alla S. Kostyukova, Michael R. Kreutz, Marina Mikhaylova
Summary: Members of the SH3 and ankyrin repeat (SHANK) protein family are considered key scaffolds at glutamatergic synapses, with missense mutations in the canonical SHANK3 isoform potentially linked to ASD. This study demonstrates that ASD-associated point mutations in SHANK3 lead to changes in protein structure, resulting in altered synaptic targeting and protein turnover at synaptic sites in rat primary hippocampal neurons.
Article
Genetics & Heredity
Hans-Juergen Kreienkamp, Matias Wagner, Heike Weigand, Allyn McConkie-Rossell, Marie McDonald, Boris Keren, Cyril Mignot, Julie Gauthier, Jean-Francois Soucy, Jacques L. Michaud, Meghan Dumas, Rosemarie Smith, Ulrike Loebel, Maja Hempel, Christian Kubisch, Jonas Denecke, Philippe M. Campeau, Jennifer M. Bain, Davor Lessel
Summary: The study identified male individuals with pathogenic or likely pathogenic variants in the HNRNPH2 gene, some showing mild developmental delay and autistic features, while others had severe neurodevelopmental delay and seizures. Functional analysis and RNA sequencing revealed the impact of the variants on protein function and gene expression.
Article
Clinical Neurology
Kasper Katisko, Nadine Huber, Tarja Kokkola, Paivi Hartikainen, Johanna Kruger, Anna-Leena Heikkinen, Veera Paananen, Ville Leinonen, Ville E. Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Valentina Cantoni, Yasmine Gadola, Silvana Archetti, Anne M. Remes, Annakaisa Haapasalo, Barbara Borroni, Eino Solje
Summary: This study found that total levels of TDP-43 in the serum are decreased in patients with frontotemporal dementia (FTD), especially in those with C9orf72 repeat expansion or concomitant motoneuron disease (FTD-MND) phenotype. Serum-based measurement of TDP-43 may serve as a useful tool for predicting TDP-43 neuropathology associated with C9orf72 repeat expansion and FTD-MND in future diagnostics and intervention studies.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Heikki Lukkarinen, Aleksi Vanninen, Ina Tesseur, Darrel Pemberton, Peter Van der Ark, Tarja Kokkola, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Kaj Blennow, Henrik Zetterberg, Ville Leinonen
Summary: There is a concentration gradient of Alzheimer's disease cerebrospinal fluid (CSF) biomarkers, including amyloid-beta 1-42 (A beta(42)), total tau (T-tau), and phosphorylated tau 181 (P-tau(181)), between intraventricular (V-CSF) and lumbar CSF (L-CSF) in iNPH patients. The study provides conversion factors between V-CSF and L-CSF, which can be used for diagnostic and prognostic purposes. Linear correlations were found between V-CSF and L-CSF concentrations, both pre- and post-operatively. The equations presented in this study offer a novel tool for clinical use when L-CSF samples are not available or when less invasive shunt reservoir samples are interpreted.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Hassani Nia, Daniel Woike, Isabel Bento, Stephan Niebling, Debora Tibbe, Kristina Schulz, Daniela Hirnet, Matilda Skiba, Hans-Hinrich Hoenck, Katharina Veith, Christian Guenther, Tasja Scholz, Tatjana Bierhals, Joenna Driemeyer, Renee Bend, Antonio Virgilio Failla, Christian Lohr, Maria Garcia Alai, Hans-Juergen Kreienkamp
Summary: This study investigates the impact of two mutations in the SHANK2 gene on neurodevelopment. The results show that these mutations disrupt the interactions of Shank2 with other proteins, leading to abnormal assembly of postsynaptic protein complexes into nanoclusters. This interference affects the positioning of neurons and synaptic transmission, ultimately impacting normal brain development in humans.
MOLECULAR PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B. Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T. Blom, Leen M. T. Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
Summary: The application of multiple omics technologies in biomedical cohorts can reveal patient-level disease characteristics and individualized response to treatment. We developed a deep-learning-based framework, MOVE, to integrate and analyze multi-omics data from a cohort of newly diagnosed type 2 diabetes patients. By using in silico perturbations, we identified drug-omics associations in the multi-modal datasets with higher sensitivity than univariate statistical tests.
NATURE BIOTECHNOLOGY
(2023)
Article
Neurosciences
Sami Heikkinen, Nadine Huber, Kasper Katisko, Tarja Kokkola, Paivi Hartikainen, Johanna Kruger, Ville Leinonen, Ville E. Korhonen, Sanna-Kaisa Herukka, Anne M. Remes, Barbara Borroni, Antonella Alberici, Ilenia Libri, Eino Solje, Annakaisa Haapasalo
Summary: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with diverse clinical phenotypes and genetic causes. This study aimed to investigate the association between serum cathepsin S levels, a lysosomal and immune function-related enzyme, and specific FTD subgroups. However, no significant alterations were found, suggesting the need for further research on alternative lysosomal proteins as potential biomarkers for FTD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Aleksi Vanninen, Heikki Lukkarinen, Tarja Kokkola, Anne M. Koivisto, Merja Kokki, Tadeusz Musialowicz, Mikko Hiltunen, Henrik Zetterberg, Ville Leinonen, Sanna-Kaisa Herukka, Tuomas Rauramaa
Summary: Alzheimer's disease (AD) is a common cause of dementia, particularly in patients with idiopathic normal pressure hydrocephalus (iNPH). The presence of AD pathology in iNPH is associated with worse outcomes after a shunt procedure. Preoperative diagnosis of AD in iNPH patients is challenging due to reduced cerebrospinal fluid (CSF) AD biomarker concentrations. Our study aimed to determine the effect of iNPH on CSF levels of AD biomarkers and investigate the potential for correction to improve diagnostic value. Results showed significant differences in biomarker levels between groups, and correction for iNPH did not improve diagnostic effectiveness. However, the P-Tau(181)/A beta(1-42) ratio showed some utility in diagnosing AD in iNPH patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Correction
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Cristina Leal Rodriguez, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan B. Hong, Petra Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe T. Muilwijk, Marieke M. Blom, Leen 't Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian N. Forgie, Giuseppe Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil W. Dermitzakis, Paul M. Franks, Jochen Schwenk, Jerzy I. Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
NATURE BIOTECHNOLOGY
(2023)
Article
Neurosciences
Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M. Maekinen, Petri Maekinen, Sasa Koncarevic, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen, Henna Martiskainen, Susanna Kemppainen, Mikael Marttinen, Heli Jeskanen, Hannah Rostalski, Eija Rahunen, Miia Kivipelto, Tiia Ngandu, Teemu Natunen, Jean-Charles Lambert, Rudolph E. Tanzi, Doo Yeon Kim, Tuomas Rauramaa, Sanna-Kaisa Herukka, Hilkka Soininen, Markku Laakso, Ian Pike, Ville Leinonen, Annakaisa Haapasalo, Mikko Hiltunen
Summary: The rare A673T variant in the amyloid precursor protein (APP) gene provides protection against Alzheimer's disease (AD). Carriers of the variant exhibit lower levels of amyloid beta (A beta) and better cognitive performance at high age. This study analyzed CSF and plasma samples from APP A673T carriers and control individuals, revealing differentially regulated targets and demonstrating the protective effects of the variant against AD-related alterations.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Sophia Weiner, Antti Junkkari, Mathias Sauer, Antti Luikku, Tuomas Rauramaa, Tarja Kokkola, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Ville Leinonen, Johan Gobom
Summary: Through proteomic analysis, we identified several potential biomarkers in the cerebrospinal fluid (CSF) that could predict the responsiveness of iNPH patients to shunt surgery. These biomarkers include FABP3, ANXA4, MIF, B3GAT2, ITGB1, YWHAG, OLFM2, TGFBI, and DSG2.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Multidisciplinary Sciences
Valtteri Julkunen, Claudia Schwarz, Juho Kalapudas, Merja Hallikainen, Aino-Kaisa Piironen, Arto Mannermaa, Hanna Kujala, Timo Laitinen, Veli-Matti Kosma, Teemu Paajanen, Reetta Kalviainen, Mikko Hiltunen, Sanna-Kaisa Herukka, Sari Karkkainen, Tarja Kokkola, Mia Urjansson, FinnGen, Markus Perola, Aarno Palotie, Eero Vuoksimaa, Heiko Runz
Summary: In order to develop novel therapies, clinical trials need to be conducted in patient cohorts with high benefit-to-risk ratio. Population-based biobanks with comprehensive health and genetic data hold promise for identifying trial participants, particularly for diseases like Alzheimer's where early intervention is crucial. This study demonstrates the feasibility of recalling FinnGen participants for a clinical study, successfully obtaining customized clinical data and validating registry entries.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li, Shuaicheng Wang, Mun-Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Gough, Leen M. 't Hart, Kaixin Zhou, Ian Forgie, Hartmut Ruetten, Imre Pavo, Pallav Bhatnagar, Angus G. Jones, Ewan R. Pearson, for the D. I. R. E. C. T. consortium DIRECT consortium
Summary: This study identified genetic variants associated with the response to GLP-1 receptor agonist treatment in patients with type 2 diabetes, which provides valuable insights for clinical decision making and personalized medicine.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Woike, Emily Wang, Debora Tibbe, Fatemeh Hassani Nia, Antonio Virgilio Failla, Maria Kibaek, Tinett Martesen Overgard, Martin J. Larsen, Christina R. Fagerberg, Igor Barsukov, Hans-Juegen Kreienkamp
Summary: Shank proteins are important for the structure of excitatory synapses. Mutations in SHANK genes are linked to autism and intellectual disability. This study identifies a new missense mutation in SHANK3 that is associated with an ADHD-like phenotype. Functional analysis shows that these mutations disrupt the interactions between Shank3 and other key molecules, leading to severe neurodevelopmental pathology.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Agata Wesolowska-Andersen, Caroline A. Brorsson, Roberto Bizzotto, Andrea Mari, Andrea Tura, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Cornelia Prehn, Anna Artati, Mun-Gwan Hong, Petra B. Musholt, Azra Kurbasic, Federico De Masi, Kostas Tsirigos, Helle Krogh Pedersen, Valborg Gudmundsdottir, Cecilia Engel Thomas, Karina Banasik, Chrisopher Jennison, Angus Jones, Gwen Kennedy, Jimmy Bell, Louise Thomas, Gary Frost, Henrik Thomsen, Kristine Allin, Tue Haldor Hansen, Henrik Vestergaard, Torben Hansen, Femke Rutters, Petra Elders, Leen T'Hart, Amelie Bonnefond, Mickael Canouil, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Andrew Hattersley, Timothy McDonald, Harriet Teare, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Philippe Froguel, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Ewan Pearson, Mark McCarthy, Soren Brunak
Summary: This study classified newly diagnosed T2D patients into different subgroups based on their disease patterns and associated biomarkers, demonstrating that the clinical heterogeneity of T2D can be mapped to heterogeneity in individual etiological processes, providing potential for personalized treatments.
CELL REPORTS MEDICINE
(2022)