In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

(2020) Fabiana Novellino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identifying the potential substrates of the depalmitoylation enzyme Acyl-protein thioesterase 1

(2019) Huicong Liu et al.   CURRENT MOLECULAR MEDICINE

Cln3 ‐mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl‐protein thioesterases‐1 (Ppt1)‐protein and Ppt1‐enzyme activity in the lysosome

(2019) Abhilash P. Appu et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Role of the endolysosomal system in Parkinson’s disease

(2019) D. J. Vidyadhara et al.   JOURNAL OF NEUROCHEMISTRY

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Toward the identification of ZDHHC enzymes required for palmitoylation of viral protein as potential drug targets

(2019) Mohamed Rasheed Gadalla et al.   Expert Opinion on Drug Discovery

Innate Immunity and Neurodegeneration

(2018) Larisa I. Labzin et al.   Annual Review of Medicine

Emerging Roles of DHHC-mediated Protein S -palmitoylation in Physiological and Pathophysiological Context

(2018) Indranil De et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy

(2018) So Woon Kim et al.   Autophagy

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

(2018) Jenny Lange et al.   Acta Neuropathologica Communications

Clinical challenges and future therapeutic approaches for neuronal ceroid lipofuscinosis

(2018) Sara E Mole et al.   LANCET NEUROLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

Reactive gliosis in the pathogenesis of CNS diseases

(2016) Milos Pekny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neurodegenerative diseases

(2016) Marie-Thérèse Heemels   NATURE

Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)

(2016) Michal Segal-Salto et al.   PLoS One

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation

(2015) Michael X. Henderson et al.   ACTA NEUROPATHOLOGICA

Cln1gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders

(2015) Goutam Chandra et al.   HUMAN MOLECULAR GENETICS

H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events

(2015) Lorena Agudo-Ibáñez et al.   MOLECULAR AND CELLULAR BIOLOGY

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

(2015) Shaun S. Sanders et al.   PLoS Computational Biology

Neuroinflammatory paradigms in lysosomal storage diseases

(2015) Megan E. Bosch et al.   Frontiers in Neuroscience

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Palmitoylation and depalmitoylation defects

(2014) Thorsten Hornemann   JOURNAL OF INHERITED METABOLIC DISEASE

An Anti-Neuroinflammatory That Targets Dysregulated Glia Enhances the Efficacy of CNS-Directed Gene Therapy in Murine Infantile Neuronal Ceroid Lipofuscinosis

(2014) S. L. Macauley et al.   JOURNAL OF NEUROSCIENCE

Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study

(2014) Sondra W Levin et al.   LANCET NEUROLOGY

The role of palmitoylation in regulating Ras localization and function

(2013) Sharon Eisenberg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotection and lifespan extension in Ppt1 −/− mice by NtBuHA: therapeutic implications for INCL

(2013) Chinmoy Sarkar et al.   NATURE NEUROSCIENCE

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of Neurodegeneration in a Mouse Model of Infantile Batten Disease by Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy

(2012) Jeeva Munasinghe et al.   Neurodegenerative Diseases

Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants

(2011) F. Takeuchi et al.   GENOME RESEARCH

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic protein palmitoylation in cellular signaling

(2009) Tsuyoshi Iwanaga et al.   PROGRESS IN LIPID RESEARCH

RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis

(2008) Arjun Saha et al.   FEBS LETTERS

Discovery of protein-palmitoylating enzymes

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