Melatonin protects against cadmium-induced oxidative stress via mitochondrial STAT3 signaling in human prostate stromal cells

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation

(2021) Margherita Peron et al.   DEVELOPMENT

Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes

(2020) Arturo Valle-Mendiola et al.   Cancers

Melatonin confers cadmium tolerance by modulating critical heavy metal chelators and transporters in radish plants

(2020) Liang Xu et al.   JOURNAL OF PINEAL RESEARCH

The Effects of Cadmium Toxicity

(2020) Giuseppe Genchi et al.   International Journal of Environmental Research and Public Health

Cyclophilin D: An Integrator of Mitochondrial Function

(2020) Georgios Amanakis et al.   Frontiers in Physiology

Redox Regulation of STAT1 and STAT3 Signaling

(2020) Elena Butturini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cadmium as a testicular toxicant: A Review

(2020) Jitender Kumar Bhardwaj et al.   JOURNAL OF APPLIED TOXICOLOGY

A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function

(2018) Mercedes Rincon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis

(2018) Rajiv Chowdhury et al.   BMJ-British Medical Journal

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress

(2017) Xinlai Cheng et al.   Scientific Reports

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

The Safety of Melatonin in Humans

(2015) Lars Peter Holst Andersen et al.   CLINICAL DRUG INVESTIGATION

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1

(2015) Adam H. Kramer et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Triggering mitophagy with far-red fluorescent photosensitizers

(2015) Cheng-Wei Hsieh et al.   Scientific Reports

Melatonin mitigates cadmium phytotoxicity through modulation of phytochelatins biosynthesis, vacuolar sequestration, and antioxidant potential in Solanum lycopersicum L

(2015) Md. Kamrul Hasan et al.   Frontiers in Plant Science

Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

(2014) Aroa Jimenéz-Aranda et al.   JOURNAL OF PINEAL RESEARCH

A review of metal-catalyzed molecular damage: protection by melatonin

(2014) Alejandro Romero et al.   JOURNAL OF PINEAL RESEARCH

N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes

(2014) Jicang Wang et al.   Journal of Veterinary Science

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro

(2014) Pan Guo et al.   TOXICOLOGICAL SCIENCES

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

(2013) S Xu et al.   Cell Death & Disease

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

(2012) C. Mantel et al.   BLOOD

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells

(2012) Pierpaolo Aimola et al.   PLoS One

Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro

(2011) Dominique Bonnefont-Rousselot et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Cadmium stress: an oxidative challenge

(2010) Ann Cuypers et al.   BIOMETALS

A Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

(2010) Raktim Mukherjee et al.   Cardiovascular Toxicology

Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells

(2010) WP Mao et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Mitochondria, reactive oxygen species and cadmium toxicity in the kidney

(2010) Glenda Gobe et al.   TOXICOLOGY LETTERS

STAT3 deletion sensitizes cells to oxidative stress

(2009) Seán P. Barry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterisation of Cadmium Chloride Induced Molecular and Functional Alterations in Airway Epithelial Cells

(2009) Efrat Forti et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat

(2009) Gamal H. El-Sokkary et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway

(2009) Nilesh M. Kalariya et al.   EXPERIMENTAL EYE RESEARCH

Cadmium and mitochondria

(2009) Giuseppe Cannino et al.   MITOCHONDRION

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Effects of Selenium with Vitamin E and Melatonin on Cadmium-Induced Oxidative Damage in Rat Liver and Kidneys

(2008) Haki Kara et al.   BIOLOGICAL TRACE ELEMENT RESEARCH