Article
Engineering, Biomedical
Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng, Chen Yang, Yumei Que
Summary: This study developed a Zn2SiO4 bioceramic that can release bioactive SiO32- and Zn2+ ions simultaneously, which have synergistic effects on promoting endothelial cell angiogenesis, inhibiting cardiomyocyte apoptosis, and protecting myocardial mitochondria against reactive oxygen species-induced injury. In vivo outcomes from a murine MI model demonstrated that systemic administration or local application of the Zn2SiO4 extract or composite hydrogel promoted cardiac function and reduced cardiac fibrosis, aiding myocardial repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lin Mei, Yunjie Chen, Peng Chen, Huinan Chen, Shengqu He, Cheng Jin, Yang Wang, Zhicheng Hu, Wanqian Li, Litai Jin, Weitao Cong, Xu Wang, Xueqiang Guan
Summary: The study found that FGF7 plays a protective role in acute myocardial infarction (MI). By inhibiting oxidative stress, FGF7 reduces cell apoptosis and improves cardiac function. FGF7 regulates oxidative stress by activating Nrf2 and scavenging ROS, as well as by promoting HXK2 and suppressing mitochondrial superoxide production. These effects are mainly mediated by the PI3K alpha/AKT signaling pathway.
Article
Medicine, Research & Experimental
Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Yi
Summary: This study demonstrates that bergenin attenuates myocardial apoptosis and oxidative damage induced by MI/R through the SIRT1 signaling pathway. Bergenin significantly reduces cardiomyocyte apoptosis and ROS production, and improves cardiac function in vitro and in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Medicinal
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana
Summary: This review summarizes the biological activities and mechanisms of action of Andrographis paniculata and andrographolide in cardiovascular health, showing their protective effects against myocardial injury through various pathways. Further validation in human clinical trials is needed to confirm their therapeutic potential.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Adriana Adameova, Csaba Horvath, Safa Abdul-Ghani, Zoltan V. Varga, M. Saadeh Suleiman, Naranjan S. Dhalla
Summary: This review highlights the importance of regulated necrosis-like cell death program in cardiac ischemic injury. Key molecules of the necroptosis signaling pathway have been found to protect the heart by reducing infarct size and improving myocardial dysfunction. The non-canonical pathway is also associated with ischemic heart injury. Oxidative stress may be involved in the mechanisms of this cell death program.
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Qian Zhang, Yuan-Ye Dang, Xiu Luo, Ji-Jun Fu, Zhi-Cong Zou, Xue-Jing Jia, Guo-Dong Zheng, Chu-Wen Li
Summary: Kazinol B (KB), an isoprenylated flavan derived from Broussonetia kazinoki Sieb. (Moraceae) root, has protective effects on hypoxia and reoxygenation-induced cardiac injury in H9c2 rat cardiac myoblasts, and its mechanism involves modulating the AKT and AMPK-mediated Nrf2 induction.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Plant Sciences
Haoyang Lu, Hui Xiao, Manyu Dai, Yangcheng Xue, Ren Zhao
Summary: This study investigated the effect and mechanism of Bri on MIR damage. The results showed that Bri significantly reduced infarct area, myocardial apoptosis, creatine phosphokinase, and lactate dehydrogenase levels, concomitant with alleviation of ferroptosis. Bri protected against ferroptosis-mediated MIR damage by upregulating GPX4 through activation of the AMPK/GSK3 beta/Nrf2 signaling.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Chu
Summary: This study found that Hesperetin has a protective effect on ISO-induced myocardial ischemia in mice, possibly by modulating oxidative stress, inflammation, and apoptosis pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Jie Yu, Xiuye Zhao, Xiuqing Yan, Wen Li, Yunqi Liu, Jiapan Wang, Jia Wang, Yilian Yang, Yan Hao, Zhen Liang, Yiping Tao, Ye Yuan, Zhimin Du
Summary: This study demonstrates that a natural anthraquinone extract called aloe-emodin (AE) can protect against acute myocardial ischemia and improve cardiac remodeling after chronic myocardial infarction (MI). AE treatment significantly improves cardiac function, reduces structural remodeling, and inhibits cardiac apoptosis and oxidative stress. Furthermore, AE activates the TGF-beta signaling pathway and regulates fibrosis-related gene expression, ultimately improving cardiac function and inhibiting cardiac fibrosis and hypertrophy.
Article
Biochemistry & Molecular Biology
Nancy S. Younis, Maged E. Mohamed
Summary: The study demonstrated the potential of anethole in protecting myocytes against myocardial infarction injury, by reducing cardiac indicators abnormalities, inflammation, and cell death through various pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Wanzhen Li, Hongxin Jiang, Chen Bai, Shuna Yu, Yitong Pan, Chenchen Wang, Huiting Li, Ming Li, Yaxin Sheng, Fangfang Chu, Jie Wang, Yuting Chen, Jianguo Li, Jiying Jiang
Summary: This study found that Ac2-26 could alleviate HIRI by inhibiting the activation of the IL-22/IL-22R1/STAT3 signaling pathway. Ac2-26 reduced oxidative stress and inhibited the mitochondrial apoptosis pathway, leading to improved liver function, reduced cell apoptosis, and alleviated inflammation.
Article
Integrative & Complementary Medicine
Bing-Jing Han, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Ji-Zhen Xie, Chun-Feng Zhang
Summary: Tetrahydropalmatine (THP) may protect the myocardium by antioxidant and anti-apoptotic effects, improving cardiac function and reducing myocardial cell damage.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gang Zhang, Xiaofeng Sun, Dongying Zhang, Xiwen Zhang, Kun Yu
Summary: This study investigated the role and molecular mechanism of nuclear factor kappa B (NFκB) and serine protease inhibitor A3 (SerpinA3) interaction in myocardial ischemia-reperfusion (IR) injury. The results demonstrated that increased expression of SerpinA3 activates NFκB and contributes to myocardial infarction. Silencing of SerpinA3 reduces inflammation, oxidative stress, and apoptosis, thus protecting the myocardium.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medical Laboratory Technology
Shunv Cai, Yixing Liu, Yun Cheng, Junbo Yuan, Jun Fang
Summary: The study demonstrated that Dex has protective effects on H9c2 cardiomyocytes exposed to H/R treatment, leading to increased cell viability, inhibited inflammatory response, suppressed apoptosis, and alleviated ER stress and oxidative stress. Dex inhibited the intrinsic pathway of apoptosis and enhanced the activation of the JAK2/STAT3 signaling pathway in H/R-treated H9c2 cells. Overall, Dex shows promise as a therapeutic agent for myocardial I/R.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Genetics & Heredity
David Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders, Xin Sheng, Alisha Chou, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mark N. Brook, Ali Sahimi, Thomas J. Hoffmann, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Kenneth Muir, Artitaya Lophatananon, Peggy Wan, Loic Le Marchand, Lynne R. Wilkens, Victoria L. Stevens, Susan M. Gapstur, Brian D. Carter, Johanna Schleutker, Teuvo L. J. Tammela, Csilla Sipeky, Anssi Auvinen, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Borge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Stig E. Bojesen, Martin Andreas Roder, Peter Iversen, Jyotsna Batra, Suzanne Chambers, Leire Moya, Lisa Horvath, Judith A. Clements, Wayne Tilley, Gail P. Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordstrom, Nora Pashayan, Alison M. Dunning, Maya Ghoussaini, Ruth C. Travis, Tim J. Key, Elio Riboli, Jong Y. Park, Thomas A. Sellers, Hui-Yi Lin, Demetrius Albanes, Stephanie J. Weinstein, Lorelei A. Mucci, Edward Giovannucci, Sara Lindstrom, Peter Kraft, David J. Hunter, Kathryn L. Penney, Constance Turman, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, Robert J. Hamilton, Neil E. Fleshner, Antonio Finelli, Marie-Elise Parent, Janet L. Stanford, Elaine A. Ostrander, Milan S. Geybels, Stella Koutros, Laura E. Beane Freeman, Meir Stampfer, Alicja Wolk, Niclas Hakansson, Gerald L. Andriole, Robert N. Hoover, Mitchell J. Machiela, Karina Dalsgaard Sorensen, Michael Borre, William J. Blot, Wei Zheng, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Yudong Wu, Shan-Chao Zhao, Zan Sun, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Catharine M. L. West, Neil Burnet, Gill Barnett, Christiane Maier, Thomas Schnoeller, Manuel Luedeke, Adam S. Kibel, Bettina F. Drake, Olivier Cussenot, Geraldine Cancel-Tassin, Florence Menegaux, Therese Truong, Yves Akoli Koudou, Esther M. John, Eli Marie Grindedal, Lovise Maehle, Kay-Tee Khaw, Sue A. Ingles, Mariana C. Stern, Ana Vega, Antonio Gomez-Caamano, Laura Fachal, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Manuel R. Teixeira, Paula Paulo, Andreia Brandao, Stephen Watya, Alexander Lubwama, Jeannette T. Bensen, Elizabeth T. H. Fontham, James Mohler, Jack A. Taylor, Manolis Kogevinas, Javier Llorca, Gemma Castano-Vinyals, Lisa Cannon-Albright, Craig C. Teerlink, Chad D. Huff, Sara S. Strom, Luc Multigner, Pascal Blanchet, Laurent Brureau, Radka Kaneva, Chavdar Slavov, Vanio Mitev, Robin J. Leach, Brandi Weaver, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Kai-Uwe Saum, Eric A. Klein, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Jeri Kim, Susan L. Neuhausen, Linda Steele, Yuan Chun Ding, William B. Isaacs, Barbara Nemesure, Anselm J. M. Hennis, John Carpten, Hardev Pandha, Agnieszka Michael, Kim De Ruyck, Gert De Meerleer, Piet Ost, Jianfeng Xu, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Lisa F. Newcomb, Daniel W. Lin, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Davor Lessel, Tomislav Kulis, Nawaid Usmani, Sandeep Singhal, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Samantha Larkin, Paul A. Townsend, Claire Aukim-Hastie, William S. Bush, Melinda C. Aldrich, Dana C. Crawford, Shiv Srivastava, Jennifer C. Cullen, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Guido Jenster, Ron H. N. van Schaik, Jennifer J. Hu, Maureen Sanderson, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Nicholas Mancuso, Sonja Berndt, Stephen K. Van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, Hidewaki Nakagawa, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Christopher A. Haiman
Summary: The study identified 86 new genetic risk variants associated with prostate cancer, bringing the total known risk variants to 269. The top genetic risk score decile showed different odds ratios for men of European, African, and East Asian ancestries, highlighting the role of germline variation and providing a potential approach for personalized risk prediction.
Correction
Genetics & Heredity
David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders, Xin Sheng, Alisha Chou, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mark N. Brook, Ali Sahimi, Thomas J. Hoffmann, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Kenneth Muir, Artitaya Lophatananon, Peggy Wan, Loic Le Marchand, Lynne R. Wilkens, Victoria L. Stevens, Susan M. Gapstur, Brian D. Carter, Johanna Schleutker, Teuvo L. J. Tammela, Csilla Sipeky, Anssi Auvinen, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Borge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Stig E. Bojesen, Martin Andreas Roder, Peter Iversen, Jyotsna Batra, Suzanne Chambers, Leire Moya, Lisa Horvath, Judith A. Clements, Wayne Tilley, Gail P. Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordstrom, Nora Pashayan, Alison M. Dunning, Maya Ghoussaini, Ruth C. Travis, Tim J. Key, Elio Riboli, Jong Y. Park, Thomas A. Sellers, Hui-Yi Lin, Demetrius Albanes, Stephanie J. Weinstein, Lorelei A. Mucci, Edward Giovannucci, Sara Lindstrom, Peter Kraft, David J. Hunter, Kathryn L. Penney, Constance Turman, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, Robert J. Hamilton, Neil E. Fleshner, Antonio Finelli, Marie-Elise Parent, Janet L. Stanford, Elaine A. Ostrander, Milan S. Geybels, Stella Koutros, Laura E. Beane Freeman, Meir Stampfer, Alicja Wolk, Niclas Hakansson, Gerald L. Andriole, Robert N. Hoover, Mitchell J. Machiela, Karina Dalsgaard Sorensen, Michael Borre, William J. Blot, Wei Zheng, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Yudong Wu, Shan-Chao Zhao, Zan Sun, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Catharine M. L. West, Neil Burnet, Gill Barnett, Christiane Maier, Thomas Schnoeller, Manuel Luedeke, Adam S. Kibel, Bettina F. Drake, Olivier Cussenot, Geraldine Cancel-Tassin, Florence Menegaux, Therese Truong, Yves Akoli Koudou, Esther M. John, Eli Marie Grindedal, Lovise Maehle, Kay-Tee Khaw, Sue A. Ingles, Mariana C. Stern, Ana Vega, Antonio Gomez-Caamano, Laura Fachal, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Manuel R. Teixeira, Paula Paulo, Andreia Brandao, Stephen Watya, Alexander Lubwama, Jeannette T. Bensen, Elizabeth T. H. Fontham, James Mohler, Jack A. Taylor, Manolis Kogevinas, Javier Llorca, Gemma Castano-Vinyals, Lisa Cannon-Albright, Craig C. Teerlink, Chad D. Huff, Sara S. Strom, Luc Multigner, Pascal Blanchet, Laurent Brureau, Radka Kaneva, Chavdar Slavov, Vanio Mitev, Robin J. Leach, Brandi Weaver, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Kai-Uwe Saum, Eric A. Klein, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Jeri Kim, Susan L. Neuhausen, Linda Steele, Yuan Chun Ding, William B. Isaacs, Barbara Nemesure, Anselm J. M. Hennis, John Carpten, Hardev Pandha, Agnieszka Michael, Kim De Ruyck, Gert De Meerleer, Piet Ost, Jianfeng Xu, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Lisa F. Newcomb, Daniel W. Lin, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Davor Lessel, Tomislav Kulis, Nawaid Usmani, Sandeep Singhal, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Samantha Larkin, Paul A. Townsend, Claire Aukim-Hastie, William S. Bush, Melinda C. Aldrich, Dana C. Crawford, Shiv Srivastava, Jennifer C. Cullen, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Guido Jenster, Ron H. N. van Schaik, Jennifer J. Hu, Maureen Sanderson, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Nicholas Mancuso, Sonja I. Berndt, Stephen K. Van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, Hidewaki Nakagawa, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Christopher A. Haiman
Article
Oncology
Roshan A. Karunamuni, Minh-Phuong Huynh-Le, Chun C. Fan, Wesley Thompson, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Groenberg, Eleanor I. Walsh, Emma L. Turner, Athene Lane, Richard M. Martin, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Borge G. Nordestgaard, Catherine M. Tangen, Robert J. MacInnis, Alicja Wolk, Demetrius Albanes, Christopher A. Haiman, Ruth C. Travis, Janet L. Stanford, Lorelei A. Mucci, Catharine M. L. West, Sune F. Nielsen, Adam S. Kibel, Fredrik Wiklund, Olivier Cussenot, Sonja I. Berndt, Stella Koutros, Karina Dalsgaard Sorensen, Cezary Cybulski, Eli Marie Grindedal, Jong Y. Park, Sue A. Ingles, Christiane Maier, Robert J. Hamilton, Barry S. Rosenstein, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Manuel R. Teixeira, Hermann Brenner, Esther M. John, Radka Kaneva, Christopher J. Logothetis, Susan L. Neuhausen, Azad Razack, Lisa F. Newcomb, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Paul A. Townsend, Monique J. Roobol, Wei Zheng, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert
Summary: In this study, we found that incorporating an additional 120 SNPs (PHS166 vs PHS46) significantly improved hazard ratios for prostate cancer, while the positive predictive value of PSA testing remained the same.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Biochemical Research Methods
Sarah Lennon, Christopher J. Hughes, Ammara Muazzam, Paul A. Townsend, Lee A. Gethings, Ian D. Wilson, Robert S. Plumb
Summary: The study introduces a high-throughput liquid chromatography tandem mass spectrometry method using 1 mm scale chromatography, which significantly reduces analysis time. It shows excellent reproducibility and was applied to identify differential expression of proteins in serum samples from a human prostate cancer study group.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Surinder M. Soond, Lyudmila V. Savvateeva, Vladimir A. Makarov, Neonila V. Gorokhovets, Paul A. Townsend, Andrey A. Zamyatnin
Summary: The study highlights the up-regulation of cathepsin S expression under Paclitaxel-stimulatory conditions and its ability to cleave the apoptotic p21 BAX protein. It also demonstrates the potential therapeutic use of CS-PEP1 as an anti-cancer agent against chemotherapeutic-resistant Renal Clear Cell Carcinoma kidney cancer cells.
Review
Biochemistry & Molecular Biology
Surinder M. Soond, Maria V. Kozhevnikova, Lyudmila V. Savvateeva, Paul A. Townsend, Andrey A. Zamyatnin
Summary: With the increasing importance of cathepsin-mediated substrate proteolysis in tumor biology, the emphasis on therapeutic design and development is growing. In order to target this interaction with tangible therapeutics, consideration must be given to the selectivity of anti- and pro-apoptotic signaling intermediates as downstream substrates for certain activated cathepsin proteases. Further exploration of 'BH3-mimetics' in modulating the relationship between these intermediates and their upstream cathepsin protease regulators is essential for improved therapeutic design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Paul A. Townsend, Maria Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin, Surinder M. Soond
Summary: Research on BH3 mimetics has led to significant advancements in cancer treatment and potential therapeutic applications in other diseases like cardiovascular conditions and tissue fibrosis, highlighting the importance of the apoptosis pathway in tissue homeostasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Minh-Phuong Huynh-Le, Roshan Karunamuni, Chun Chieh Fan, Lui Asona, Wesley K. Thompson, Maria Elena Martinez, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth R. Muir, Artitaya Lophatananon, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, Henrik Groenberg, David E. Neal, Borge G. Nordestgaard, Catherine M. Tangen, Robert J. MacInnis, Alicja Wolk, Demetrius Albanes, Christopher A. Haiman, Ruth C. Travis, William J. Blot, Janet L. Stanford, Lorelei A. Mucci, Catharine M. L. West, Sune F. Nielsen, Adam S. Kibel, Olivier Cussenot, Sonja Berndt, Stella Koutros, Karina Dalsgaard Sorensen, Cezary Cybulski, Eli Marie Grindedal, Florence Menegaux, Jong Y. Park, Sue A. Ingles, Christiane Maier, Robert J. Hamilton, Barry S. Rosenstein, Yong-Jie Lu, Stephen Watya, Ana Vega, Manolis Kogevinas, Fredrik Wiklund, Kathryn L. Penney, Chad D. Huff, Manuel R. Teixeira, Luc Multigner, Robin J. Leach, Hermann Brenner, Esther M. John, Radka Kaneva, Christopher J. Logothetis, Susan L. Neuhausen, Kim De Ruyck, Piet Ost, Azad Razack, Lisa F. Newcomb, Jay H. Fowke, Marija Gamulin, Aswin Abraham, Frank Claessens, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Ron H. N. van Schaik, Marie-Elise Parent, Jennifer J. Hu, Wei Zheng, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert
Summary: This study evaluates the effect of using single-nucleotide polymorphisms (SNPs) for prostate cancer risk stratification, and finds that including additional SNPs improves the association with clinically significant prostate cancer in multi-ancestry datasets. This is promising for implementing precision-medicine approaches to prostate cancer screening decisions in diverse populations.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Ammara Muazzam, Davide Chiasserini, Janet Kelsall, Nophar Geifman, Anthony D. Whetton, Paul A. Townsend
Summary: Prostate cancer is the third most common cancer in men globally. The PSA is the main protein biomarker used for diagnosis, staging, and monitoring, but it can lead to inaccurate diagnosis and overtreatment. Therefore, identifying novel biomarkers for prostate cancer can help improve the understanding of diagnosis and risk assessment.
Article
Biochemistry & Molecular Biology
Rebecca C. Jones, Kevin M. Lawrence, Scott M. Higgins, Stephen M. Richardson, Paul A. Townsend
Summary: Post-traumatic osteoarthritis (PTOA) is characterized by rapid chondrocyte cell death and a shift in cell phenotype towards a more catabolic state. This study shows that urocortin-1 (Ucn) can protect chondrocytes from death and prevent cartilage degradation in a PTOA model. The protective effect of Ucn is mediated through the CRF-R1 receptor and involves blocking of intracellular calcium accumulation through the Piezo1 channel. These findings suggest that Ucn could be a novel disease-modifying osteoarthritis drug (DMOAD) for preventing impact overload-induced PTOA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daiana Drehmer, Joao Paulo Mesquita Luiz, Cesar Augusto Speck Hernandez, Jose Carlos Alves-Filho, Tracy Hussell, Paul Andrew Townsend, Salvador Moncada
Summary: This study demonstrates that nitric oxide (NO) produced by colon and prostate cancer cells affects tumor-associated macrophages (TAMs), leading to changes in TAMs' phenotype and impairing their antigen-presenting and wound healing capacities.
Article
Chemistry, Analytical
Holly-May Lewis, Priyanka Gupta, Kyle D. G. Saunders, Shazneil Briones, Johanna von Gerichten, Paul A. Townsend, Eirini Velliou, Dany J. V. Beste, Olivier Cexus, Roger Webb, Melanie J. Bailey
Summary: This work presents a new approach for measuring drug levels and lipid fingerprints in individual living mammalian cells. The method combines nanocapillary sampling with liquid chromatography to improve precision in drug analysis. By optimizing the transfer of analytes from the sampling capillary, the researchers achieved efficient measurement of drug analytes in 30 living cells. They also discovered cell-to-cell heterogeneity in drug molecule uptake and identified lipid features associated with bedaquiline uptake.
Review
Pharmacology & Pharmacy
Andrey A. Zamyatnin Jr, Levy C. Gregory, Paul A. Townsend, Surinder M. Soond
Summary: In this article, the importance of Cathepsin B (CtsB) in cancer progression is reviewed, highlighting its complex molecular involvement with various regulatory processes. The article details the development of CtsB-specific Activity-Based Probes, the evolution of these towards a new generation of Prodrugs, and the evaluation of their therapeutic potential as anti-cancer agents in the clinic.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Genetics & Heredity
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Ammara Muazzam, Matt Spick, Olivier N. F. Cexus, Bethany Geary, Fowz Azhar, Hardev Pandha, Agnieszka Michael, Rachel Reed, Sarah Lennon, Lee A. Gethings, Robert S. Plumb, Anthony D. Whetton, Nophar Geifman, Paul A. Townsend
Summary: Despite ongoing research, effective tools for detection and monitoring of prostate cancer are still lacking. This study aims to identify non-invasive biomarkers that can complement PSA in clinical decision-making. Novel prostate cancer protein signatures were discovered using an advanced analytical technique, and the results were validated using a second cohort of patients. The study provides a proteomic signature that can enhance the diagnosis and risk assessment of localized prostate cancer.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
