Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation

The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions

(2021) Annachiara Tesoriere et al.   Biomedicines

The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent

(2020) Margherita Peron et al.   DEVELOPMENT

Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease

(2020) Elena Buglo et al.   PLoS One

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

(2020) Jesse J. Balic et al.   Nature Communications

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

(2020) Jonathan Martinez-Fabregas et al.   Cell Reports

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

(2019) Aaron M. Savage et al.   Nature Communications

The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria

(2019) Laura Martorano et al.   Disease Models & Mechanisms

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Glycochenodeoxycholate induces cell survival and chemoresistance via phosphorylation of STAT3 at Ser727 site in HCC

(2019) Jue Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of cardiac Wnt/β-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention

(2018) Alice Giuliodori et al.   CARDIOVASCULAR RESEARCH

RNA-dependent RNA targeting by CRISPR-Cas9

(2018) Steven C Strutt et al.   eLife

STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses

(2018) Lidia Avalle et al.   CELL DEATH AND DIFFERENTIATION

Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation

(2017) Yinzi Liu et al.   PLoS Genetics

nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor

(2017) N. Facchinello et al.   Scientific Reports

Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

(2016) Nishant P. Visavadiya et al.   Cell Communication and Signaling

Embryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain

(2016) Sonya Galant et al.   DEVELOPMENTAL BIOLOGY

Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency

(2016) Elena Carbognin et al.   EMBO JOURNAL

STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC

(2016) Sarani Ghoshal et al.   HEPATOBILIARY SURGERY AND NUTRITION

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

(2015) Joy Y. Feng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RNA-seq of the aging brain in the short-lived fishN. furzeri- conserved pathways and novel genes associated with neurogenesis

(2014) Mario Baumgart et al.   AGING CELL

JAK2-STAT3 Blockade by AG490 Suppresses Autoimmune Arthritis in Mice via Reciprocal Regulation of Regulatory T Cells and Th17 Cells

(2014) J.-S. Park et al.   JOURNAL OF IMMUNOLOGY

Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes

(2014) Everardo Macias et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

STAT3 Signaling Is Activated Preferentially in Tumor-Initiating Cells in Claudin-Low Models of Human Breast Cancer

(2014) Wei Wei et al.   STEM CELLS

Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro

(2014) VENHAR GURBUZ et al.   Oncology Letters

Cancer Stem Cells Activate STAT3 the EZ Way

(2013) Shaun D. Fouse et al.   CANCER CELL

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain

(2013) Anne Mohr et al.   Cell Communication and Signaling

Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor

(2013) Graziano Martello et al.   EMBO JOURNAL

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

(2013) Daniel J. Gough et al.   PLoS One

STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates

(2013) Guanyi Huang et al.   STEM CELLS

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

(2012) C. Mantel et al.   BLOOD

The stat3/socs3a Pathway Is a Key Regulator of Hair Cell Regeneration in Zebrafish stat3/socs3a Pathway: Regulator of Hair Cell Regeneration

(2012) J. Liang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

Two-color fluorescent in situ hybridization in the embryonic zebrafish brain using differential detection systems

(2011) Gilbert Lauter et al.   BMC DEVELOPMENTAL BIOLOGY

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

(2011) J R Matthews et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

(2011) Karol Szczepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation

(2009) Jeong-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation

(2008) H. R. Qin et al.   CANCER RESEARCH

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols