Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses

Breaking Through the Therapeutic Ceiling: What Will It Take?

(2022) Tim Raine et al.   GASTROENTEROLOGY

Entering the Era of Disease Modification in Inflammatory Bowel Disease

(2022) Ailsa Hart et al.   GASTROENTEROLOGY

Early Symptomatic Improvement After Ustekinumab Therapy in Patients With Ulcerative Colitis: 16-Week Data From the UNIFI Trial

(2022) Silvio Danese et al.   Clinical Gastroenterology and Hepatology

Efficacy and Safety of Maintenance Ustekinumab for Ulcerative Colitis Through 3 Years: UNIFI Long-term Extension

(2022) Maria T Abreu et al.   Journal of Crohns & Colitis

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

(2021) Christopher N. Foley et al.   Nature Communications

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

(2021) Yeda Wu et al.   Nature Communications

Systemic Inflammation in Preclinical Ulcerative Colitis

(2021) Daniel Bergemalm et al.   GASTROENTEROLOGY

Large-scale integration of the plasma proteome with genetics and disease

(2021) Egil Ferkingstad et al.   NATURE GENETICS

Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets

(2021) Antonio F. Di'Narzo et al.   GASTROENTEROLOGY

Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis

(2020) Joana Torres et al.   GASTROENTEROLOGY

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

(2019) In Young Lee et al.   MOLECULAR CELL

Th17 plasticity and its relevance to inflammatory bowel disease

(2018) Aito Ueno et al.   JOURNAL OF AUTOIMMUNITY

Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair

(2018) Tsuyoshi Fukushima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression Patterns of TNFα, MAdCAM1, and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease

(2017) Stephan R Vavricka et al.   Journal of Crohns & Colitis

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

(2017) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The druggable genome and support for target identification and validation in drug development

(2017) Chris Finan et al.   Science Translational Medicine

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors

(2017) Antonio F. Di Narzo et al.   PLoS Genetics

STAT3 signaling in immunity

(2016) Emily J. Hillmer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci

(2016) Antonio F Di Narzo et al.   Clinical and Translational Gastroenterology

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling

(2010) Michael J. Schell   CELLULAR AND MOLECULAR LIFE SCIENCES

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT