Breaking Through the Therapeutic Ceiling: What Will It Take?

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

(2021) Dan Turner et al.   GASTROENTEROLOGY

Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn’s disease

(2020) Ryan C Ungaro et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Modulating the microbiome to improve therapeutic response in cancer

(2019) Jennifer L McQuade et al.   LANCET ONCOLOGY

Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study

(2019) Sanjay K Murthy et al.   GUT

Competition for Clinical Trials in Inflammatory Bowel Diseases

(2019) M. Scott Harris et al.   GASTROENTEROLOGY

Adaptive platform trials: definition, design, conduct and reporting considerations

(2019)   NATURE REVIEWS DRUG DISCOVERY

DEVELOPMENT AND VALIDATION OF A TEST TO MONITOR ENDOSCOPIC ACTIVITY IN PATIENTS WITH CROHN’S DISEASE BASED ON SERUM LEVELS OF PROTEINS

(2019) Geert D’Haens et al.   GASTROENTEROLOGY

Combining Biologics in Inflammatory Bowel Disease and Other Immune Mediated Inflammatory Disorders

(2018) Robert P. Hirten et al.   Clinical Gastroenterology and Hepatology

Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

(2017) Sudarshan Paramsothy et al.   Journal of Crohns & Colitis

Early anti-TNF/immunomodulator therapy is associated with better long-term clinical outcomes in Asian patients with Crohn’s disease with poor prognostic factors

(2017) Eun Hye Oh et al.   PLoS One

Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery

(2017) Dong-won Lee et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis

(2016) Gaik W. Tew et al.   GASTROENTEROLOGY

Standardisation of Study Protocols – Pros and Cons

(2016) Geert D’Haens   Journal of Crohns & Colitis

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

Development of Red Flags Index for Early Referral of Adults with Symptoms and Signs Suggestive of Crohn’s Disease: An IOIBD Initiative

(2015) Silvio Danese et al.   Journal of Crohns & Colitis

Diagnostic delay in a French cohort of Crohn's disease patients

(2014) Stéphane Nahon et al.   Journal of Crohns & Colitis

Patients Enrolled in Randomized Controlled Trials Do Not Represent the Inflammatory Bowel Disease Patient Population

(2012) Christina Ha et al.   Clinical Gastroenterology and Hepatology