Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair

Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas

(2018) Tsuyoshi Fukushima et al.   CANCER SCIENCE

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

(2018) Chen Chen et al.   GASTROENTEROLOGY

The impaired proteases and anti-proteases balance in Idiopathic Pulmonary Fibrosis

(2018) Awen Menou et al.   MATRIX BIOLOGY

Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): Emerging key players in epithelial integrity and cancer

(2018) Hiroaki Kataoka et al.   PATHOLOGY INTERNATIONAL

Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin

(2018) Shiao-Pieng Lee et al.   PLoS One

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert

(2018) Geoffrey Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells

(2018) Koji Yamamoto et al.   Oncotarget

Alarmins of the extracellular space

(2018) Jenna L. Dziki et al.   SEMINARS IN IMMUNOLOGY

The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition.

(2017) Min Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1

(2017) Tomohiro Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB proteins and arthritis

(2017) Noboru Taniguchi et al.   Human Cell

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert

(2017) Joseph T. Rodgers et al.   Cell Reports

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Plasma macrophage-stimulating protein and hepatocyte growth factor levels are associated with prostate cancer progression

(2015) Satoru Sugie et al.   Human Cell

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Integrating EMR-Linked and In Vivo Functional Genetic Data to Identify New Genotype-Phenotype Associations

(2014) Jonathan D. Mosley et al.   PLoS One

Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues

(2014) Makiko Kawaguchi et al.   Cancers

Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase

(2013) Brian R. Larsen et al.   EXPERIMENTAL CELL RESEARCH

Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase

(2011) Takahiro Domoto et al.   CANCER SCIENCE

Hepatocyte growth factor twenty years on: Much more than a growth factor

(2011) Takahiro Nakamura et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor

(2010) Koji Suzuki   FEBS Journal

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)

(2010) Charles Eigenbrot et al.   FEBS Journal

Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo

(2010) Hiroaki Kataoka et al.   FEBS Journal

Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor

(2010) Keiji Miyazawa   FEBS Journal

Imbalance in the Pro–Hepatocyte Growth Factor Activation System in Bleomycin-Induced Lung Fibrosis in Mice

(2009) Sophie Phin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA

(2009) Kate A. Owen et al.   BIOCHEMICAL JOURNAL

Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein

(2009) Makiko Kawaguchi et al.   FEBS Journal

Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases

(2008) Shoichiro Mukai et al.   FEBS Journal

Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution

(2008) Miyuki Nagai et al.   PATHOLOGY INTERNATIONAL

Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice

(2007) T Hamada et al.   GUT