Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases

(2016) Wei Luo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci

(2015) Imge Hulur et al.   BMC GENOMICS

From Prescription to Transcription: Genome Sequence as Drug Target

(2015) Cong Guo et al.   CELL

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

(2015) Raymond E. Soccio et al.   CELL

Characterization of Expression Quantitative Trait Loci in the Human Colon

(2015) Tarjinder Singh et al.   INFLAMMATORY BOWEL DISEASES

Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway

(2015) Seung-Hyun Hong et al.   Oncotarget

Intelectin-1 Is a Prominent Protein Constituent of Pathologic Mucus Associated with Eosinophilic Airway Inflammation in Asthma

(2014) Sheena C. Kerr et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: Role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1

(2014) Romain Pacaud et al.   BIOCHIMIE

Meta-eQTL: a tool set for flexible eQTL meta-analysis

(2014) Antonio Fabio Di Narzo et al.   BMC BIOINFORMATICS

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human treg cells are characterized by low/negative CD6 expression

(2014) Carlos A. Garcia Santana et al.   CYTOMETRY PART A

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

(2014) Rhiannon Parkhouse et al.   FEBS LETTERS

ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice

(2014) Yu-Hwai Tsai et al.   GASTROENTEROLOGY

Determining causality and consequence of expression quantitative trait loci

(2014) A. Battle et al.   HUMAN GENETICS

Regulated expression of leukocyte-specific transcript (LST) 1 in human intestinal inflammation

(2014) Jan Heidemann et al.   INFLAMMATION RESEARCH

Opposite Effects of Interferon Regulatory Factor 1 and Osteopontin on the Apoptosis of Epithelial Cells Induced by TNF-α in Inflammatory Bowel Disease

(2014) Ruihan Tang et al.   INFLAMMATORY BOWEL DISEASES

The Microtubule-associated Protein EB1 Links AIM2 Inflammasomes with Autophagy-dependent Secretion

(2014) Li-Jie Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation

(2014) James M. Kennedy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

FRA2 Is a STAT5 Target Gene Regulated by IL-2 in Human CD4 T Cells

(2014) Aradhana Rani et al.   PLoS One

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+T cells

(2014) John A. Altin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic regulation of gene expression in the lung identifiesCST3andCD22as potential causal genes for airflow obstruction

(2014) Maxime Lamontagne et al.   THORAX

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

(2013) Rebeccah J Mathews et al.   ANNALS OF THE RHEUMATIC DISEASES

The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy

(2013) Yu Lei et al.   Autophagy

PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy

(2013) Simone Patergnani et al.   Autophagy

Dynamic trans-Acting Factor Colocalization in Human Cells

(2013) Dan Xie et al.   CELL

The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination

(2013) Bishi Fu et al.   CELL RESEARCH

MAIT cells, surveyors of a new class of antigen: development and functions

(2013) Lionel Le Bourhis et al.   CURRENT OPINION IN IMMUNOLOGY

Multiple activating and repressive cis -promoter regions regulate TNFSF15 expression in human primary mononuclear cells

(2013) Rivkah Gonsky et al.   CYTOKINE

Expression Quantitative Trait Loci Analysis Identifies Associations Between Genotype and Gene Expression in Human Intestine

(2013) Boyko Kabakchiev et al.   GASTROENTEROLOGY

Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice

(2013) Harry Sokol et al.   GASTROENTEROLOGY

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease

(2013) Christopher G. Mayne et al.   INFLAMMATORY BOWEL DISEASES

Gene expression of tumor necrosis factor receptor associated-factor (TRAF)-1 and TRAF-2 in inflammatory bowel disease

(2013) Yu Qi Qiao et al.   Journal of Digestive Diseases

The Gene Expression Barcode 3.0: improved data processing and mining tools

(2013) Matthew N. McCall et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

A Dual Role for SAGA-Associated Factor 29 (SGF29) in ER Stress Survival by Coordination of Both Histone H3 Acetylation and Histone H3 Lysine-4 Trimethylation

(2013) Andrea W. Schram et al.   PLoS One

Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes

(2013) E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

(2013) Sung Gil Ha et al.   Nature Communications

A Statistical Framework for Joint eQTL Analysis in Multiple Tissues

(2013) Timothée Flutre et al.   PLoS Genetics

Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches

(2013) Jae Hoon Sul et al.   PLoS Genetics

A review of post-GWAS prioritization approaches

(2013) Lin Hou et al.   Frontiers in Genetics

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes

(2012) Katja Christodoulou et al.   GUT

GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness

(2012) Mi-Jin Kang et al.   HUMAN IMMUNOLOGY

Mucosal genome-wide methylation changes in inflammatory bowel disease

(2012) James Cooke et al.   INFLAMMATORY BOWEL DISEASES

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation

(2012) C. Schiller et al.   JOURNAL OF CELL SCIENCE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

(2012) Bryan Howie et al.   NATURE GENETICS

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

ZFP36L1 Negatively Regulates Plasmacytoid Differentiation of BCL1 Cells by Targeting BLIMP1 mRNA

(2012) Asghar Nasir et al.   PLoS One

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort

(2011) D. M. Greenawalt et al.   GENOME RESEARCH

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation

(2011) Allison M Beal et al.   NATURE IMMUNOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation

(2011) Gianna Palmieri et al.   PLoS One

IRF5 is required for late-phase TNF secretion by human dendritic cells

(2010) T. Krausgruber et al.   BLOOD

Quality control and quality assurance in genotypic data for genome-wide association studies

(2010) Cathy C. Laurie et al.   GENETIC EPIDEMIOLOGY

Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease

(2010) Karin Fransen et al.   HUMAN MOLECULAR GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach

(2010) Enrico Petretto et al.   PLoS Computational Biology

Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis

(2009) Pallavi Garg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GCN5 is a required cofactor for a ubiquitin ligase that targets NF- B/RelA

(2009) X. Mao et al.   GENES & DEVELOPMENT

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ischemic Colitis: Surging Waves of Update

(2009) Michael Stamatakos et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of Cullin-box Sequences That Direct Recruitment of Cul2-Rbx1 and Cul5-Rbx2 Modules to Elongin BC-based Ubiquitin Ligases

(2008) Nawel Mahrour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis

(2008) E. Bergeret et al.   JOURNAL OF CELL SCIENCE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY