Barriers to immune cell infiltration in tumors

Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine

(2023) Christine A Tran et al.   Journal for ImmunoTherapy of Cancer

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

(2022) Adele M. Nicolas et al.   CANCER CELL

Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment

(2022) Lihong Wang et al.   Journal for ImmunoTherapy of Cancer

Delivery of CXCL9/10/11 plasmid DNAs promotes the tumor-infiltration of T cells and synergizes with PD1 antibody for treating lung cancer

(2022) Yuxia Ma et al.   Cancer Nanotechnology

Randomized, Double-Blind, Placebo-Controlled, Global Phase III Trial of Talimogene Laherparepvec Combined With Pembrolizumab for Advanced Melanoma

(2022) Jason A. Chesney et al.   JOURNAL OF CLINICAL ONCOLOGY

CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma

(2022) Guoqing Wang et al.   MOLECULAR THERAPY

Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade

(2022) Hohyun Lee et al.   Science Advances

Afferent Lymphatic Transport and Peripheral Tissue Immunity

(2021) Maria M. Steele et al.   JOURNAL OF IMMUNOLOGY

Perineuronal nets stabilize the grid cell network

(2021) Ane Charlotte Christensen et al.   Nature Communications

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

(2021) Kevin Litchfield et al.   CELL

Differential expression of CD49a and CD49b determines localization and function of tumor-infiltrating CD8+ T cells

(2021) Marit M Melssen et al.   Cancer Immunology Research

A FIJI macro for quantifying pattern in extracellular matrix

(2021) Esther Wershof et al.   Life Science Alliance

Chemokines and the immune response to cancer

(2021) Aleksandra J. Ozga et al.   IMMUNITY

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

(2021) Anthony B. Rodriguez et al.   Cell Reports

Therapeutic Induction of Tertiary Lymphoid Structures in Cancer Through Stromal Remodeling

(2021) Anna Johansson-Percival et al.   Frontiers in Immunology

Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

(2021) Tiarne van de Walle et al.   Frontiers in Immunology

Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma

(2021) Troels Holz Borch et al.   Journal for ImmunoTherapy of Cancer

Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma

(2021) Kevin T Lynch et al.   Journal for ImmunoTherapy of Cancer

Vascular Normalization: A New Window Opened for Cancer Therapies

(2021) Ting Yang et al.   Frontiers in Oncology

Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

(2021) Yuan Xie et al.   JCI Insight

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

(2020) Kirsty Ford et al.   CANCER RESEARCH

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

(2020) Jihyeon Lee et al.   Stem Cell Research

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy

(2020) Shibin Qu et al.   Journal for ImmunoTherapy of Cancer

The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response

(2020) Gadi Cohen et al.   Cancers

TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection

(2020) Emma C. Reilly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine

(2020) Ryu Kanzaki et al.   CANCER SCIENCE

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

(2020) Junbin Qian et al.   CELL RESEARCH

The significance of stromal collagen organization in cancer tissue: An in-depth discussion of literature

(2020) Stéphanie M. Zunder et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen

(2020) Yurina Ogawa et al.   CLINICAL CANCER RESEARCH

MR‐guided pulsed focused ultrasound improves mesenchymal stromal cell homing to the myocardium

(2020) Kee W. Jang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity

(2020) Natasha D Sheybani et al.   Journal for ImmunoTherapy of Cancer

The VE-Cadherin/β-catenin signalling axis regulates immune cell infiltration into tumours

(2020) Yang Zhao et al.   CANCER LETTERS

Transcriptomic response of brain tissue to focused ultrasound‐mediated blood–brain barrier disruption depends strongly on anesthesia

(2020) Alexander S. Mathew et al.   Bioengineering & Translational Medicine

Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes

(2019) Hawley C. Pruitt et al.   MATRIX BIOLOGY

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III–IV melanoma

(2019) Robert H. I. Andtbacka et al.   Journal for ImmunoTherapy of Cancer

The emerging role of epigenetic therapeutics in immuno-oncology

(2019) Michael J. Topper et al.   Nature Reviews Clinical Oncology

The Proteomic Effects of Pulsed Focused Ultrasound on Tumor Microenvironments of Murine Melanoma and Breast Cancer Models

(2019) Omer Aydin et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

(2019) Gregg B. Fields   Cells

The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis

(2019) Katie M. Leick et al.   ANNALS OF SURGERY

High Intensity Focused Ultrasound (HIFU) Triggers Immune Sensitization of Refractory Murine Neuroblastoma to Checkpoint Inhibitor Therapy

(2019) Avinash Eranki et al.   CLINICAL CANCER RESEARCH

Effect of Pulsed Focused Ultrasound on the Native Pancreas

(2019) Mehdi Razavi et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity

(2018) Victor H. Engelhard et al.   JOURNAL OF IMMUNOLOGY

Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures

(2018) Anne M. Stowman et al.   MELANOMA RESEARCH

Overexpression of adhesion molecules and barrier molecules is associated with differential infiltration of immune cells in non-small cell lung cancer

(2018) Young Kwang Chae et al.   Scientific Reports

Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas

(2018) Gabriel Espinosa-Carrasco et al.   Frontiers in Immunology

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

(2018) Edmund K. Moon et al.   OncoImmunology

High response rate to PD-1 blockade in desmoplastic melanomas

(2018) Zeynep Eroglu et al.   NATURE

Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade

(2018) Ye Qin et al.   ONCOGENE

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

(2018) Marit M. Melssen et al.   OncoImmunology

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer

(2018) Maria Georganaki et al.   Frontiers in Immunology

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors

(2017) Tommaso Torcellan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

(2017) Julienne L. Carstens et al.   Nature Communications

Limb proportions show developmental plasticity in response to embryo movement

(2017) A. S. Pollard et al.   Scientific Reports

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

(2017) Dallan McMahon et al.   Theranostics

Combined Anti-VEGF and Anti–CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes

(2017) Xinqi Wu et al.   Cancer Immunology Research

Differential Expression of Homing Receptor Ligands on Tumor-Associated Vasculature that Control CD8 Effector T-cell Entry

(2017) Amber N. Woods et al.   Cancer Immunology Research

Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases

(2016) Ileana S. Mauldin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Paracrine tumor signaling induces transdifferentiation of surrounding fibroblasts

(2016) Petr Heneberg   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

PD-1 Blockade Expands Intratumoral Memory T Cells

(2016) A. Ribas et al.   Cancer Immunology Research

Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma Patients

(2016) Timothy Murray et al.   Frontiers in Immunology

Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk

(2016) Elise P. Salerno et al.   OncoImmunology

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

(2015) Hua Huang et al.   FASEB JOURNAL

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells

(2015) Heather D. Hickman et al.   IMMUNITY

TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10

(2015) Ileana S. Mauldin et al.   INTERNATIONAL JOURNAL OF CANCER

CpG expedites regression of local and systemic tumors when combined with activatable nanodelivery

(2015) Azadeh Kheirolomoom et al.   JOURNAL OF CONTROLLED RELEASE

Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization

(2015) S. Ariotti et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms

(2015) Gerardo Cárcamo-Oyarce et al.   Nature Communications

CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy

(2015) Zuqiang Liu et al.   OncoImmunology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins

(2013) Elise P. Salerno et al.   INTERNATIONAL JOURNAL OF CANCER

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

(2013) Michael G Overstreet et al.   NATURE IMMUNOLOGY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Peripheral Tissue Homing Receptor Control of Naïve, Effector, and Memory CD8 T Cell Localization in Lymphoid and Non-Lymphoid Tissues

(2013) C. Colin Brinkman et al.   Frontiers in Immunology

CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma

(2012) G. Erdag et al.   CANCER RESEARCH

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Nitric Oxide–Producing Myeloid-Derived Suppressor Cells Inhibit Vascular E-Selectin Expression in Human Squamous Cell Carcinomas

(2012) Ahmed E. Gehad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Egfl7 Promotes Tumor Escape from Immunity by Repressing Endothelial Cell Activation

(2011) S. Delfortrie et al.   CANCER RESEARCH

Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway

(2011) Audrey Le Floc'h et al.   CANCER RESEARCH

CTLA4 Blockade Induces Frequent Tumor Infiltration by Activated Lymphocytes Regardless of Clinical Responses in Humans

(2011) R. R. Huang et al.   CLINICAL CANCER RESEARCH

Intravital imaging of CTLs killing islet cells in diabetic mice

(2011) Ken Coppieters et al.   JOURNAL OF CLINICAL INVESTIGATION

A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma

(2011) Omid Hamid et al.   Journal of Translational Medicine

Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR-1

(2011) Tomasz P. Rygiel et al.   MOLECULAR IMMUNOLOGY

Investigation of Cellular and Molecular Responses to Pulsed Focused Ultrasound in a Mouse Model

(2011) Scott R. Burks et al.   PLoS One

High response rate after intratumoral treatment with interleukin-2

(2010) Benjamin Weide et al.   CANCER

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements during the Course of Inflammation

(2010) M. N. Brown et al.   JOURNAL OF IMMUNOLOGY

Interferons Induce CXCR3-cognate Chemokine Production by Human Metastatic Melanoma

(2010) Lynn T. Dengel et al.   JOURNAL OF IMMUNOTHERAPY

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

(2009) H. Harlin et al.   CANCER RESEARCH

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

(2009) D. Bogunovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

(2008) Béatrice Breart et al.   JOURNAL OF CLINICAL INVESTIGATION

Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells

(2008) Rachael A. Clark et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE