Afferent Lymphatic Transport and Peripheral Tissue Immunity

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy

(2020) Andreane Cartier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

(2020) Wenji Piao et al.   Cell Reports

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

(2020) Guillermo Oliver et al.   CELL

Biological functions of lymphatic vessels

(2020) Tatiana V. Petrova et al.   SCIENCE

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

(2020) Ashley C. Bolte et al.   Nature Communications

PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

(2020) Erin D. Lucas et al.   Cell Reports

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

(2019) Maria M. Steele et al.   Jove-Journal of Visualized Experiments

Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages

(2019) Sang Heon Suh et al.   EMBO REPORTS

The Interplay Between Lymphatic Vessels and Chemokines

(2019) Rae H. Farnsworth et al.   Frontiers in Immunology

Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity

(2019) Alan J. Hayes et al.   Frontiers in Immunology

Lymphatic Cannulation for Lymph Sampling and Molecular Delivery

(2019) David C. Zawieja et al.   JOURNAL OF IMMUNOLOGY

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

(2018) Dennis Jones et al.   Science Translational Medicine

CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

(2018) Gabriela D. García Nores et al.   Nature Communications

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

(2018) Caroline L. Sokol et al.   IMMUNITY

Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response

(2018) Erin D. Lucas et al.   JOURNAL OF IMMUNOLOGY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Lacteal junction zippering protects against diet-induced obesity

(2018) Feng Zhang et al.   SCIENCE

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

(2018) Ryan S. Lane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors

(2017) Tommaso Torcellan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

(2017) Manuel Fankhauser et al.   Science Translational Medicine

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation

(2017) Samantha Arokiasamy et al.   Scientific Reports

Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection

(2017) Christopher P. Loo et al.   Cell Reports

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia

(2017) Kari Vaahtomeri et al.   Cell Reports

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions

(2017) Alvaro Teijeira et al.   Cell Reports

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

Local antigen in nonlymphoid tissue promotes resident memory CD8+T cell formation during viral infection

(2016) Tahsin N. Khan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leishmania majorInfection–Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease

(2016) Tiffany Weinkopff et al.   JOURNAL OF IMMUNOLOGY

ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes

(2016) Steven A. Bryce et al.   JOURNAL OF IMMUNOLOGY

Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help

(2016) Norifumi Iijima et al.   NATURE

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

(2016) C. Colin Brinkman et al.   Nature Communications

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

(2015) Denise Morais da Fonseca et al.   CELL

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation

(2015) Daniela Gómez et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

(2015) Laura K. Mackay et al.   JOURNAL OF IMMUNOLOGY

Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin-dependent proteolysis and lipoxin-induced junctional retraction

(2015) David A. Rigby et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

(2015) Henry R. Hampton et al.   Nature Communications

Inflammation-induced lymphangiogenesis and lymphatic dysfunction

(2014) Shan Liao et al.   ANGIOGENESIS

VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

(2014) Silvia D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

(2014) A. Pegu et al.   JOURNAL OF IMMUNOLOGY

Incorporation of CpG into a Liposomal Vaccine Formulation Increases the Maturation of Antigen-Loaded Dendritic Cells and Monocytes To Improve Local and Systemic Immunity

(2014) M. R. Neeland et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes

(2014) Carolina V. Gorlino et al.   JOURNAL OF IMMUNOLOGY

CXCR4 Is Dispensable for T Cell Egress from Chronically Inflamed Skin via the Afferent Lymph

(2014) Skye A. Geherin et al.   PLoS One

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

(2014) A. M. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic Vessel Memory Stimulated by Recurrent Inflammation

(2013) Philip M. Kelley et al.   AMERICAN JOURNAL OF PATHOLOGY

An analysis of the function and expression of D6 on lymphatic endothelial cells

(2013) C. S. McKimmie et al.   BLOOD

CD44 Binds to Macrophage Mannose Receptor on Lymphatic Endothelium and Supports Lymphocyte Migration via Afferent Lymphatics

(2013) Marko Salmi et al.   CIRCULATION RESEARCH

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement

(2013) Giorgia Jurisic et al.   INFLAMMATORY BOWEL DISEASES

 1 1 Integrin-Mediated Adhesion Inhibits Macrophage Exit from a Peripheral Inflammatory Lesion

(2013) H. M. Becker et al.   JOURNAL OF IMMUNOLOGY

Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

(2013) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

Lymphatic Endothelium Forms Integrin-Engaging 3D Structures during DC Transit across Inflamed Lymphatic Vessels

(2013) Álvaro Teijeira et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7

(2013) Skye A. Geherin et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation

(2012) Li-Chin Yao et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation

(2012) M. Nitschke et al.   BLOOD

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema

(2012) Tomer Avraham et al.   FASEB JOURNAL

The Skin, a Novel Niche for Recirculating B Cells

(2012) S. A. Geherin et al.   JOURNAL OF IMMUNOLOGY

Tissue Exit: a Novel Control Point in the Accumulation of Antigen-Specific CD8 T Cells in the Influenza A Virus-Infected Lung

(2012) S. Jennrich et al.   JOURNAL OF VIROLOGY

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner

(2011) B. Vigl et al.   BLOOD

D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion

(2011) K. M. Lee et al.   BLOOD

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling

(2011) Orna Tal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

   T Cell Homing to Skin and Migration to Skin-Draining Lymph Nodes Is CCR7 Independent

(2011) M. Vrieling et al.   JOURNAL OF IMMUNOLOGY

Cross-Talk Between TCR and CCR7 Signaling Sets a Temporal Threshold for Enhanced T Lymphocyte Migration

(2011) K. Schaeuble et al.   JOURNAL OF IMMUNOLOGY

Regressed lymphatic vessels develop during corneal repair

(2011) Philip M Kelley et al.   LABORATORY INVESTIGATION

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

CCR7 is involved in the migration of neutrophils to lymph nodes

(2010) C. Beauvillain et al.   BLOOD

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration

(2010) Louise A. Johnson et al.   INTERNATIONAL IMMUNOLOGY

Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice

(2010) Michio Tomura et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

(2010) Reto Huggenberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemoattractant Receptors and Lymphocyte Egress from Extralymphoid Tissue: Changing Requirements during the Course of Inflammation

(2010) M. N. Brown et al.   JOURNAL OF IMMUNOLOGY

The Origin and Maturity of Dendritic Cells Determine the Pattern of Sphingosine 1-Phosphate Receptors Expressed and Required for Efficient Migration

(2010) A. Rathinasamy et al.   JOURNAL OF IMMUNOLOGY

Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation

(2009) Marika Karikoski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection

(2009) Heung Kyu Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking Development of a CD8+ T Cell Response by Targeting Lymphatic Recruitment of APC

(2009) D. Teoh et al.   JOURNAL OF IMMUNOLOGY

Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-Engineered Lymph Node Microenvironment

(2009) A. A. Tomei et al.   JOURNAL OF IMMUNOLOGY

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

(2009) S. Podgrabinska et al.   JOURNAL OF IMMUNOLOGY

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

(2009) Sammy Bedoui et al.   NATURE IMMUNOLOGY

Transgenic Induction of Vascular Endothelial Growth Factor-C Is Strongly Angiogenic in Mouse Embryos but Leads to Persistent Lymphatic Hyperplasia in Adult Tissues

(2008) Marja Lohela et al.   AMERICAN JOURNAL OF PATHOLOGY

VE-cadherin and β-catenin binding dynamics during histamine-induced endothelial hyperpermeability

(2008) Mingzhang Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the VEGFR-3 Pathway by VEGF-C Attenuates UVB-Induced Edema Formation and Skin Inflammation by Promoting Lymphangiogenesis

(2008) Kentaro Kajiya et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

(2008) Heather D Hickman et al.   NATURE IMMUNOLOGY