Increased Expression of Autophagy-Related Genes in Alzheimer’s Disease—Type 2 Diabetes Mellitus Comorbidity Models in Cells

The role of ATG16L2 in autophagy and disease

(2022) Laurence Don Wai Luu et al.   Autophagy

Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy

(2022) Parisa Koutsifeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose metabolism and AD: evidence for a potential diabetes type 3

(2022) Andrea González et al.   Alzheimers Research & Therapy

Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US

(2022) Eric L. Ross et al.   JAMA Neurology

Diabetes and dementia: Clinical perspective, innovation, knowledge gaps

(2022) Masha G. Savelieff et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Incretin and insulin signaling as novel therapeutic targets for Alzheimer’s and Parkinson’s disease

(2022) Joseph Nowell et al.   MOLECULAR PSYCHIATRY

Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets

(2022) Rim Hamzé et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lecanemab for Alzheimer's disease: tempering hype and hope

(2022) The Lancet   LANCET

Altered mRNA Levels of Stress-Related Peptides in Mouse Hippocampus and Caudate-Putamen in Withdrawal after Long-Term Intermittent Exposure to Tobacco Smoke or Electronic Cigarette Vapour

(2021) Lucia Carboni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

ATG16L1 functions in cell homeostasis beyond autophagy

(2021) Daniel Hamaoui et al.   FEBS Journal

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(2021) David S. Knopman et al.   Nature Reviews Disease Primers

Whole Blood Transcriptome Characterization of 3xTg-AD Mouse and Its Modulation by Transcranial Direct Current Stimulation (tDCS)

(2021) Chiara Magri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in metabolic disease and ageing

(2021) Munehiro Kitada et al.   Nature Reviews Endocrinology

Revisiting FDA Approval of Aducanumab

(2021) G. Caleb Alexander et al.   NEW ENGLAND JOURNAL OF MEDICINE

Approval of Aducanumab for Alzheimer Disease—the FDA’s Perspective

(2021) Billy Dunn et al.   JAMA Internal Medicine

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

(2020) Marine Jacquet et al.   Autophagy

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment

(2020) Lucia Carboni et al.   Cells

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

(2020) Loan Vaillant-Beuchot et al.   ACTA NEUROPATHOLOGICA

Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2020) Tom L. Broderick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

(2020) Bradlee L. Heckmann et al.   Science Advances

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1

(2019) Bernard Khor et al.   JOURNAL OF IMMUNOLOGY

Sweet Mitochondria: A Shortcut to Alzheimer’s Disease

(2018) Paula I. Moreira   JOURNAL OF ALZHEIMERS DISEASE

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer’s disease

(2018) Meina Wu et al.   NEUROSCIENCE LETTERS

Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production

(2018) Stefano Capaldi et al.   Scientific Reports

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

(2018) Mirta Borin et al.   Acta Neuropathologica Communications

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

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(2018) Ramona Belfiore et al.   AGING CELL

Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure

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Comorbidity Analysis between Alzheimer’s Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs

(2017) Reagon Karki et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons

(2016) Yunhua Peng et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia

(2015) Saion Chatterjee et al.   DIABETES CARE

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

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Molecular Mechanism of Autophagic Membrane-Scaffold Assembly and Disassembly

(2014) Anna Kaufmann et al.   CELL

Pharmacological targeting of the β-amyloid precursor protein intracellular domain

(2014) Caterina Branca et al.   Scientific Reports

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

(2013) Ning Li et al.   JOURNAL OF CLINICAL INVESTIGATION

β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons

(2013) Silvia Bolognin et al.   NEUROCHEMISTRY INTERNATIONAL

Two-Photon Microscopy Imaging of thy1GFP-M Transgenic Mice: A Novel Animal Model to Investigate Brain Dendritic Cell Subsets In Vivo

(2013) Claudia Laperchia et al.   PLoS One

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

(2012) Sónia C. Correia et al.   BRAIN RESEARCH

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

(2011) Koutaro Ishibashi et al.   Autophagy

Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease

(2011) Jong-Yeon Shin et al.   BMB Reports

Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons

(2011) Bhumsoo Kim et al.   ENDOCRINOLOGY

A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experiments

(2011) Robin A Clark et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE