Comorbidity Analysis between Alzheimer’s Disease and Type 2 Diabetes Mellitus (T2DM) Based on Shared Pathways and the Role of T2DM Drugs

Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus

(2016) Nor Bahirah Kasim et al.   Biomarkers in Medicine

Upregulation of microRNA-206 enhances lipopolysaccharide-induced inflammation and release of amyloid-β by targeting insulin-like growth factor 1 in microglia

(2016) Hongxia Xing et al.   Molecular Medicine Reports

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

Computable cause-and-effect models of healthy and Alzheimer's disease states and their mechanistic differential analysis

(2015) Alpha Tom Kodamullil et al.   Alzheimers & Dementia

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Major Depressive Disorder and Type II Diabetes Mellitus: Mechanisms Underlying Risk for Alzheimer’s Disease

(2015) Danielle Cha et al.   CNS & Neurological Disorders-Drug Targets

Chemical profiling with HPLC-FTMS of exogenous and endogenous chemicals susceptible to the administration of chotosan in an animal model of type 2 diabetes-induced dementia

(2015) Yimin Niu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

(2014) Gurdeep Marwarha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epigenomic Approach in Understanding Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2014) Munvar Shaik et al.   CNS & Neurological Disorders-Drug Targets

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

(2014) Chin-Chou Huang et al.   PLoS One

Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese

(2013) Linlin Li et al.   GENE

‘HypothesisFinder:’ A Strategy for the Detection of Speculative Statements in Scientific Text

(2013) Ashutosh Malhotra et al.   PLoS Computational Biology

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

(2013) Cesare Patrone et al.   Lancet Diabetes & Endocrinology

Mining biomarker information in biomedical literature

(2012) Erfan Younesi et al.   BMC Medical Informatics and Decision Making

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

Analysis of microRNA expression profile induced by AICAR in mouse hepatocytes

(2012) Jia Liu et al.   GENE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug-Induced Parkinsonism

(2012) Hae-Won Shin et al.   Journal of Clinical Neurology

Heparin-binding epidermal growth factor–like growth factor promotes murine enteric nervous system development and enteric neural crest cell migration

(2012) Yu Zhou et al.   JOURNAL OF PEDIATRIC SURGERY

Role of AMPK in pancreatic beta cell function

(2012) Accalia Fu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits

(2012) Xuan Ye et al.   NEUROBIOLOGY OF AGING

Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures

(2012) Dong-Hou Kim et al.   NEUROBIOLOGY OF DISEASE

Risk of Alzheimer’s Disease in Relation to Diabetes: A Population-Based Cohort Study

(2012) Kai-Chen Wang et al.   NEUROEPIDEMIOLOGY

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes

(2011) Bhumsoo Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

GLUT4 Gene Polymorphisms and Their Association with Type 2 Diabetes in South Indians

(2011) Dhanasekaran Bodhini et al.   Diabetes Technology & Therapeutics

Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia

(2011) Tom Schilling et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice

(2011) Qi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroprotective strategies involving ROS in Alzheimer disease

(2010) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of IGF-1 Receptor and Insulin Receptor Signaling for the Pathogenesis of Alzheimers Disease: From Model Organisms to Human Disease

(2009) S. Freude et al.   Current Alzheimer Research

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL