Early DNase-I therapy delays secondary brain damage after traumatic brain injury in adult mice

Ribonuclease-1 treatment after traumatic brain injury preserves blood–brain barrier integrity and delays secondary brain damage in mice

(2022) Tobias J. Krämer et al.   Scientific Reports

AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice

(2022) Ralph Timaru-Kast et al.   Scientific Reports

Role of the Extracellular Traps in Central Nervous System

(2021) Xinyan Wu et al.   Frontiers in Immunology

Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

(2020) Lars Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deoxyribonuclease Reduces Tissue Injury and Improves Survival After Hemorrhagic Shock

(2020) Joaquin Cagliani et al.   JOURNAL OF SURGICAL RESEARCH

Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients

(2020) Julien Pottecher et al.   Trials

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury

(2020) Kumar Vaibhav et al.   Science Advances

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Administration of all‐ trans retinoic acid after experimental traumatic brain injury is brain protective

(2020) Regina Hummel et al.   BRITISH JOURNAL OF PHARMACOLOGY

PAI-1 augments damage by impairing fibrinolysis after traumatic brain injury

(2019) Eva-Verena Griemert et al.   ANNALS OF NEUROLOGY

Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats

(2019) Ashley M. Fortress et al.   EXPERIMENTAL NEUROLOGY

Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance

(2019) Carolina Peña-Martínez et al.   STROKE

Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury

(2019) Tobias J. Krämer et al.   Journal of Neuroinflammation

Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury

(2018) Jianning Zhang et al.   BLOOD

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Large Vessel Vasospasm Is Not Associated with Cerebral Cortical Hypoperfusion in a Murine Model of Subarachnoid Hemorrhage

(2018) Axel Neulen et al.   Translational Stroke Research

Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient

(2018) Mickael Vourc’h et al.   Frontiers in Immunology

Prognostic utility of circulating nucleic acids in acute brain injuries

(2018) Andrea Regner et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection

(2017) Tobias Krämer et al.   JOURNAL OF NEUROCHEMISTRY

Comparison of speed-vacuum method and heat-drying method to measure brain water content of small brain samples

(2017) Anne Sebastiani et al.   JOURNAL OF NEUROSCIENCE METHODS

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

(2017) Philipp Stieger et al.   Journal of the American Heart Association

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury

(2016) Lutz Menzel et al.   GLIA

Epidemiology of Traumatic Brain Injury in Europe: A Living Systematic Review

(2016) Alexandra Brazinova et al.   JOURNAL OF NEUROTRAUMA

Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice

(2016) Hassan Albadawi et al.   JOURNAL OF VASCULAR SURGERY

Influence of Age on Cerebral Housekeeping Gene Expression for Normalization of Quantitative Polymerase Chain Reaction after Acute Brain Injury in Mice

(2015) Ralph Timaru-Kast et al.   JOURNAL OF NEUROTRAUMA

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

(2014) Eva-Verena Schaible et al.   JOURNAL OF NEUROCHEMISTRY

Elevated Cell-Free Plasma DNA Level as an Independent Predictor of Mortality in Patients with Severe Traumatic Brain Injury

(2014) Edison Moraes Rodrigues Filho et al.   JOURNAL OF NEUROTRAUMA

Traumatic Brain Injury Associated Coagulopathy

(2014) Airton Leonardo de Oliveira Manoel et al.   Neurocritical Care

Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumatic Brain Injury*

(2013) Serge C. Thal et al.   CRITICAL CARE MEDICINE

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Differences in brain edema and intracranial pressure following traumatic brain injury across the estrous cycle: Involvement of female sex steroid hormones

(2012) Fatemeh Maghool et al.   BRAIN RESEARCH

Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury

(2012) Hada Macher et al.   CLINICA CHIMICA ACTA

Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice

(2012) Ralph Timaru-Kast et al.   PLoS One

Structural Requirements for the Procoagulant Activity of Nucleic Acids

(2012) Julia Gansler et al.   PLoS One

Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury

(2012) Serge C. Thal et al.   PLoS One

Micro-Computed Tomography for Hemorrhage Disruption of Mouse Brain Vasculature

(2012) Bohua Xie et al.   Translational Stroke Research

Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*

(2011) Ralph Timaru-Kast et al.   CRITICAL CARE MEDICINE

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pioglitazone Reduces Secondary Brain Damage after Experimental Brain Trauma by PPAR-γ-Independent Mechanisms

(2011) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

von Willebrand Factor

(2011) Simon F. De Meyer et al.   STROKE

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

(2010) S. A. Smith et al.   BLOOD

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Cell death mechanisms and modulation in traumatic brain injury

(2010) Bogdan A. Stoica et al.   Neurotherapeutics

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Selection of Endogenous Control Genes for Normalization of Gene Expression Analysis after Experimental Brain Trauma in Mice

(2008) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

Dynamic Changes in the Recovery after Traumatic Brain Injury in Mice: Effect of Injury Severity on T2-Weighted MRI Abnormalities, and Motor and Cognitive Functions

(2008) Jeanna Tsenter et al.   JOURNAL OF NEUROTRAUMA

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE