Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection

Fumarate decreases edema volume and improves functional outcome after experimental stroke

(2017) Bettina Hjelm Clausen et al.   EXPERIMENTAL NEUROLOGY

Fumaric Acid Esters Attenuate Secondary Degeneration after Spinal Cord Injury

(2017) Marika Cordaro et al.   JOURNAL OF NEUROTRAUMA

Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

(2016) Trevor M. Penning   CHEMICAL RESEARCH IN TOXICOLOGY

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury

(2016) Lutz Menzel et al.   GLIA

Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats

(2016) Ruihe Lin et al.   Journal of Neuroinflammation

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro

(2016) Lina Du et al.   JOURNAL OF NEUROTRAUMA

The more the merrier? Scoring, statistics and animal welfare in experimental autoimmune encephalomyelitis

(2016) Pushpalatha Palle et al.   LABORATORY ANIMALS

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Serial Oxidative Stress Levels in Acute Traumatic Brain Injury and as Predictors of Outcome

(2016) Hung-Chen Wang et al.   World Neurosurgery

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

(2016) Yang Yao et al.   Translational Stroke Research

Emerging Roles for the Immune System in Traumatic Brain Injury

(2016) Celia A. McKee et al.   Frontiers in Immunology

Peripheral Inflammatory Markers and Antioxidant Response during the Post-Acute and Chronic Phase after Severe Traumatic Brain Injury

(2016) Federico Licastro et al.   Frontiers in Neurology

Traumatic Brain Injury and Mitochondrial Dysfunction

(2015) John B. Hiebert et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood–brain barrier integrity

(2015) Reiner Kunze et al.   EXPERIMENTAL NEUROLOGY

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

(2015) Duvyanshu Dubey et al.   Expert Review of Neurotherapeutics

Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury

(2015) Changsheng Huang et al.   GLIA

Characterization of traumatic brain injury in human brains reveals distinct cellular and molecular changes in contusion and pericontusion

(2015) Gangadharappa Harish et al.   JOURNAL OF NEUROCHEMISTRY

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

(2015) Yizhi Liu et al.   JOURNAL OF NEUROSURGERY

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

(2015) Loretta O. Iniaghe et al.   NEUROBIOLOGY OF DISEASE

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

(2015) Duvyanshu Dubey et al.   Expert Review of Neurotherapeutics

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

The Blood–Brain Barrier as a Target in Traumatic Brain Injury Treatment

(2014) Serge C. Thal et al.   ARCHIVES OF MEDICAL RESEARCH

Regulators of mitochondrial Ca2+ homeostasis in cerebral ischemia

(2014) Michael K. E. Schäfer et al.   CELL AND TISSUE RESEARCH

N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI

(2014) Jignesh D. Pandya et al.   EXPERIMENTAL NEUROLOGY

Mode of action and clinical studies with fumarates in multiple sclerosis

(2014) Anke Salmen et al.   EXPERIMENTAL NEUROLOGY

A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma

(2014) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

(2014) Eva-Verena Schaible et al.   JOURNAL OF NEUROCHEMISTRY

Temporal and Spatial Dynamics of Nrf2-Antioxidant Response Elements Mediated Gene Targets in Cortex and Hippocampus after Controlled Cortical Impact Traumatic Brain Injury in Mice

(2014) Darren M. Miller et al.   JOURNAL OF NEUROTRAUMA

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Cost of traumatic brain injury in New Zealand: Evidence from a population-based study

(2014) B. Te Ao et al.   NEUROLOGY

Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury

(2014) Katharine Eakin et al.   PLoS One

Contributions of the immune system to the pathophysiology of traumatic brain injury – evidence by intravital microscopy

(2014) Susanne M. Schwarzmaier et al.   Frontiers in Cellular Neuroscience

In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice

(2013) Susanne M Schwarzmaier et al.   Journal of Neuroinflammation

Transcranial amelioration of inflammation and cell death after brain injury

(2013) Theodore L. Roth et al.   NATURE

Novel therapeutic options and drug targets in MS

(2013) Axel Methner et al.   Nature Reviews Neurology

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-Inflammatory Efficacy of Dexamethasone and Nrf2 Activators in the CNS Using Brain Slices as a Model of Acute Injury

(2012) David J. Graber et al.   Journal of Neuroimmune Pharmacology

Effects of dimethyl fumarate on neuroprotection and immunomodulation

(2012) Philipp Albrecht et al.   Journal of Neuroinflammation

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages

(2011) Kahina Abbas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Charcot–Marie–Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential

(2011) Rebecca Noack et al.   HUMAN MOLECULAR GENETICS

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

(2011) Mushfiquddin Khan et al.   Journal of Neuroinflammation

Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

(2011) C. Escartin et al.   JOURNAL OF NEUROSCIENCE

Control of Redox State and Redox Signaling by Neural Antioxidant Systems

(2010) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Craniotomy: True Sham for Traumatic Brain Injury, or a Sham of a Sham?

(2010) Jeffrey T. Cole et al.   JOURNAL OF NEUROTRAUMA

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Role of Nrf2 in Protection against Traumatic Brain Injury in Mice

(2009) Wei Jin et al.   JOURNAL OF NEUROTRAUMA

Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury

(2008) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Time Course of Contusion-Induced Oxidative Stress and Synaptic Proteins in Cortex in a Rat Model of TBI

(2008) Mubeen A. Ansari et al.   JOURNAL OF NEUROTRAUMA

Selection of Endogenous Control Genes for Normalization of Gene Expression Analysis after Experimental Brain Trauma in Mice

(2008) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

Dynamic Changes in the Recovery after Traumatic Brain Injury in Mice: Effect of Injury Severity on T2-Weighted MRI Abnormalities, and Motor and Cognitive Functions

(2008) Jeanna Tsenter et al.   JOURNAL OF NEUROTRAUMA

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET