Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds

(2016) T.L. Petkau et al.   NEUROSCIENCE

Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

(2015) Masato Kanazawa et al.   BRAIN

The contribution of astrocytes and microglia to traumatic brain injury

(2015) Ila P Karve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats

(2015) Bo Li et al.   CRITICAL CARE MEDICINE

Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury

(2015) Changsheng Huang et al.   GLIA

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1  and TNF- 

(2015) E. Hennessy et al.   JOURNAL OF NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

New discovery rarely runs smooth: an update on progranulin/TNFR interactions

(2015) Betty C. Wang et al.   Protein & Cell

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Regulators of mitochondrial Ca2+ homeostasis in cerebral ischemia

(2014) Michael K. E. Schäfer et al.   CELL AND TISSUE RESEARCH

Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2

(2014) Mareike Caesar et al.   GLIA

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries

(2014) Catarina Raposo et al.   GLIA

Traumatic white matter injury and glial activation: From basic science to clinics

(2014) Zhifeng Kou et al.   GLIA

TLR2 Expression in Astrocytes Is Induced by TNF- - and NF- B-Dependent Pathways

(2014) N. K. Phulwani et al.   JOURNAL OF IMMUNOLOGY

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

(2014) Eva-Verena Schaible et al.   JOURNAL OF NEUROCHEMISTRY

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date

(2014) Antonino Tuttolomondo et al.   Drug Design Development and Therapy

Temporal Dynamics of Cerebral Blood Flow, Cortical Damage, Apoptosis, Astrocyte–Vasculature Interaction and Astrogliosis in the Pericontusional Region after Traumatic Brain Injury

(2014) Sonia Villapol et al.   Frontiers in Neurology

Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice

(2014) Yoshinori Tanaka et al.   Acta Neuropathologica Communications

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus

(2013) Shanshan Zhu et al.   BRAIN RESEARCH

Traumatic brain injury induces macrophage subsets in the brain

(2013) Christine L. Hsieh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progranulin Deficiency Promotes Post-Ischemic Blood-Brain Barrier Disruption

(2013) K. Jackman et al.   JOURNAL OF NEUROSCIENCE

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Dissociation of Frontotemporal Dementia-Related Deficits and Neuroinflammation in Progranulin Haploinsufficient Mice

(2013) A. J. Filiano et al.   JOURNAL OF NEUROSCIENCE

Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-αContents and by Stimulating Newly Formed Neurogenesis

(2013) Chong-Un Cheong et al.   MEDIATORS OF INFLAMMATION

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice

(2013) Y. Tanaka et al.   NEUROSCIENCE

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

(2013) Eva-Verena Schaible et al.   PLoS One

Progranulin Mutations as Risk Factors for Alzheimer Disease

(2013) David C. Perry et al.   JAMA Neurology

Isolation and Culture of Mouse Cortical Astrocytes

(2013) Sebastian Schildge et al.   Jove-Journal of Visualized Experiments

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage

(2012) Katherine R. Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Effects of FK506 on Structural and Functional Axonal Deficits After Diffuse Brain Injury in the Immature Rat

(2012) Ann Mae DiLeonardi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

(2012) Y. Tanaka et al.   NEUROSCIENCE

Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice

(2012) Ralph Timaru-Kast et al.   PLoS One

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice

(2011) Hee-Young Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Delayed inflammatory mRNA and protein expression after spinal cord injury

(2011) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

(2011) W. Liu et al.   LIFE SCIENCES

Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

(2011) Marco Vercellino et al.   Multiple Sclerosis Journal

Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins

(2011) Sandra Almeida et al.   PLoS One

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Radiation-Induced Astrogliosis and Blood-Brain Barrier Damage Can Be Abrogated Using Anti-TNF Treatment

(2009) Christy M. Wilson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury

(2009) Roberta Brambilla et al.   JOURNAL OF NEUROCHEMISTRY

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Mutations in Progranulin Gene: Clinical, Pathological, and Ribonucleic Acid Expression Findings

(2008) Adolfo López de Munain et al.   BIOLOGICAL PSYCHIATRY

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Selection of Endogenous Control Genes for Normalization of Gene Expression Analysis after Experimental Brain Trauma in Mice

(2008) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

Dynamic Changes in the Recovery after Traumatic Brain Injury in Mice: Effect of Injury Severity on T2-Weighted MRI Abnormalities, and Motor and Cognitive Functions

(2008) Jeanna Tsenter et al.   JOURNAL OF NEUROTRAUMA