2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats

(2013) Cheng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIF-1α Involves in Neuronal Apoptosis after Traumatic Brain Injury in Adult Rats

(2013) Aihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

(2013) Eva-Verena Schaible et al.   PLoS One

The tissue-type plasminogen activator–plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

(2012) Maithili Sashindranath et al.   BRAIN

Estrogen Metabolite 2-methoxyestradiol Prevents Hypertension in Deoxycorticosterone Acetate-salt Rats

(2012) Wensu Yuan et al.   CARDIOVASCULAR DRUGS AND THERAPY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia

(2012) Neetu Singh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Microtubules Regulate Hypoxia-inducible Factor-1α Protein Trafficking and Activity

(2012) Marisa Carbonaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?

(2012) Saravanan S Karuppagounder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of hypoxia-inducible factor 1 in atherosclerosis: Figure 1

(2012) Linggen Gao et al.   JOURNAL OF CLINICAL PATHOLOGY

Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus

(2012) Mariola Marx et al.   NEUROGENETICS

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival

(2012) Elisa Conde et al.   PLoS One

Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice

(2012) Xuemei Jin et al.   PLoS One

Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice

(2012) Ralph Timaru-Kast et al.   PLoS One

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation

(2012) G. S. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Activation of hypoxia-inducible factor-1  (Hif-1 ) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

(2011) P. M. Elks et al.   BLOOD

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

(2011) Marisa Carbonaro et al.   JOURNAL OF CELL BIOLOGY

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation

(2011) Clara Luh et al.   PLoS One

Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury

(2011) Adel Helmy et al.   PROGRESS IN NEUROBIOLOGY

Selective Inhibition of Early-but Not Late-Expressed HIF-1α Is Neuroprotective in Rats after Focal Ischemic Brain Damage

(2010) Shiu-Hwa Yeh et al.   BRAIN PATHOLOGY

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

(2010) Tsunehiko Yoshida et al.   FASEB JOURNAL

Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration

(2010) Lana Kupershmidt et al.   JOURNAL OF NEUROCHEMISTRY

CREB activation mediates VEGF-A’s protection of neurons and cerebral vascular endothelial cells

(2010) Hsueh-Te Lee et al.   JOURNAL OF NEUROCHEMISTRY

2-Methoxyestradiol—Biology and mechanism of action

(2010) A.O. Mueck et al.   STEROIDS

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury

(2009) Clara Luh et al.   JOURNAL OF NEUROCHEMISTRY

Mouse models for preeclampsia: disruption of redox-regulated signaling

(2009) Subhasis Banerjee et al.   Reproductive Biology and Endocrinology

Antioxidants, HIF Prolyl Hydroxylase Inhibitors or Short Interfering RNAs to BNIP3 or PUMA, Can Prevent Prodeath Effects of the Transcriptional Activator, HIF-1α, in a Mouse Hippocampal Neuronal Line

(2008) Leila R. Aminova et al.   ANTIOXIDANTS & REDOX SIGNALING

Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis

(2008) Antonino Tuttolomondo et al.   ATHEROSCLEROSIS

Turn me on: regulating HIF transcriptional activity

(2008) K Lisy et al.   CELL DEATH AND DIFFERENTIATION

Prodeath or prosurvival: Two facets of hypoxia inducible factor-1 in perinatal brain injury

(2008) Wanqiu Chen et al.   EXPERIMENTAL NEUROLOGY

Selection of Endogenous Control Genes for Normalization of Gene Expression Analysis after Experimental Brain Trauma in Mice

(2008) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy

(2008) J. E. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA