Review
Hematology
Irina Portier, Robert A. Campbell
Summary: Platelets, traditionally viewed as essential in hemostasis and thrombosis, have recently been recognized for their role in modulating the immune response during infectious diseases. Through the release of antimicrobial proteins upon activation, platelets can directly limit pathogen growth and aid in pathogen clearance by activating immune cells. However, abnormal platelet activation may lead to inflammation and thrombotic events.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Alicia S. Eustes, Robert A. Campbell, Elizabeth A. Middleton, Neal D. Tolley, Bhanu K. Manne, Emilie Montenont, Jesse W. Rowley, Krystin Krauel, Antoinette Blair, Li Guo, Yasuhiro Kosaka, Isabel M. Medeiros-de-Moraes, Marcus Lacerda, Eugenio D. Hottz, Hugo Castro Faria Neto, Guy A. Zimmerman, Andrew S. Weyrich, Aaron Petrey, Matthew T. Rondina
Summary: During clinical sepsis, translation and enzymatic activity of HPSE are increased in platelets. Increased expression of the active form of HPSE protein is associated with sepsis-associated mortality.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pharmacology & Pharmacy
Marina Malovichko, Wesley T. Abplanalp, Samantha A. McFall, Breandon S. Taylor, Nalinie S. Wickramasinghe, Israel D. Sithu, Igor N. Zelko, Shizuka Uchida, Bradford G. Hill, Saurin R. Sutaria, Michael H. Nantz, Aruni Bhatnagar, Daniel J. Conklin, Timothy E. O'Toole, Sanjay Srivastava
Summary: Exposure to benzene is associated with an increased risk for cardiovascular disease. Benzene inhalation induces endothelial injury, enhances platelet activation and inflammatory processes, and increases levels of platelet-leukocyte aggregates and microparticles derived from endothelial cells and platelets in the bloodstream.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Immunology
Patrice Cunningham, Christian A. Unger, Emma A. Patton, Akyla Aiken, Alea Browne, Ella James, Ahmed K. Aladhami, Marion C. Hope, Brandon N. Vanderveen, Thomas D. Cardaci, E. Angela Murphy, Reilly T. Enos, Kandy T. Velazquez
Summary: This study investigated the immunopathogenesis of cancer cachexia using the Apc(Min/+) mouse model. The study revealed an elevated platelet count prior to the development of cachexia in the mice, as well as increased expression of certain markers in the skeletal muscle. Behavioral and metabolic phenotype analysis showed decreased physical activity in the pre-cachectic mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Friedrich Reusswig, Amin Polzin, Meike Klier, Matthias Achim Dille, Aysel Ayhan, Marcel Benkhoff, Celina Lersch, Anika Prinz, Simone Gorressen, Jens Walter Fischer, Malte Kelm, Margitta Elvers
Summary: Platelets play a crucial role in thrombosis and inflammation after acute myocardial infarction (AMI). Acute thrombocytopenia can reduce infarct size and improve cardiac function, while chronic thrombocytopenia does not have a protective effect on heart function.
Article
Cardiac & Cardiovascular Systems
Meaghan E. Colling, Benjamin E. Tourdot, Yogendra Kanthi
Summary: The association between inflammation, infection, and venous thrombosis is crucial and can lead to pathological thrombosis. Cells like neutrophils, monocytes, and platelets play essential roles in host defense and thrombus formation. Understanding these mechanisms has advanced knowledge in human physiology and pathophysiology, offering new therapeutic targets for the treatment of thrombosis.
CIRCULATION RESEARCH
(2021)
Article
Hematology
Preeti Maurya, Sara K. Ture, Chen Li, Kristin M. Scheible, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelet transfusions are commonly used in preterm neonates with thrombocytopenia to reduce the risk of bleeding, but there is limited clinical evidence to support this practice. This study found that adult and neonatal platelets have differential effects on monocyte immune functions, which may affect neonatal immune function and transfusion complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Jeffrey S. Berger, Matthew D. Neal, Lucy Z. Kornblith, Michelle N. Gong, Harmony R. Reynolds, Mary Cushman, Andrew D. Althouse, Patrick R. Lawler, Bryan J. McVerry, Keri S. Kim, Lisa Baumann Kreuziger, Scott D. Solomon, Mikhail N. Kosiborod, Scott M. Berry, Grant V. Bochicchio, Marco Contoli, Michael E. Farkouh, Joshua D. Froess, Sheetal Gandotra, Yonatan Greenstein, Erinn M. Hade, Nicholas Hanna, Kristin Hudock, Robert C. Hyzy, Fatima Ibanez Estellez, Nicole Iovine, Ashish K. Khanna, Pooja Khatri, Bridget-Anne Kirwan, Matthew E. Kutcher, Eric Leifer, George Lim, Renato D. Lopes, Jose L. Lopez-Sendon, James F. Luther, Lilia Nigro Maia, John G. Quigley, Lana Wahid, Jennifer G. Wilson, Ryan Zarychanski, Andrei Kindzelski, Mark W. Geraci, Judith S. Hochman
Summary: This study evaluated the effect of P2Y12 inhibition on critically ill patients hospitalized for COVID-19. The randomized clinical trial showed that the use of P2Y12 inhibitors did not improve the number of days alive and free of cardiovascular or respiratory organ support. Therefore, routine use of P2Y12 inhibitors is not recommended in critically ill patients hospitalized for COVID-19.
Review
Biochemistry & Molecular Biology
Silvia M. G. Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri, Marta Zara
Summary: Platelets play a crucial role in hemostasis and thrombosis, but they are also involved in various physiological and pathological processes, including infection. They are among the first responders recruited to sites of inflammation and infection, actively cooperating with the immune system to exert their antimicrobial response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Angie de la Cruz, Aubrey Hargrave, Sri Magadi, Justin A. Courson, Paul T. Landry, Wanyu Zhang, Fong W. Lam, Monica A. Bray, C. Wayne Smith, Alan R. Burns, Rolando E. Rumbaut
Summary: Platelet extravasation during inflammation is influenced by CD18, PMNs, and mast cell degranulation. Injured corneas with deficiencies in CD18 or mast cells show reduced platelet and RBC extravasation, highlighting the importance of these factors in the process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Huy Quang Quach, Christina Johnson, Karin Ekholt, Rakibul Islam, Tom Eirik Mollnes, Per H. Nilsson
Summary: In this study, we investigated the role of thrombin and platelets in interleukin 8 (IL-8) release. Our findings suggest that IL-8 release is mediated by leukocytes, mainly monocytes, but is potentiated by thrombin-dependent activation of platelets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Hematology
Florian Puhm, Eric Boilard, Kellie R. Machlus
Summary: Extracellular vesicles (EVs) are a means of cell-to-cell communication, and platelets readily generate EVs upon activation, containing diverse cargo that can enter various bodily fluids. The importance of platelet-derived EVs extends beyond hemostasis, highlighting their physiological and pathological significance.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Article
Sport Sciences
Dan Lin, Cheryl L. Thompson, Djibril M. Ba, Joshua E. Muscat, Shouhao Zhou, Connie J. Rogers, Kathleen M. Sturgeon
Summary: The study revealed an inverse association between leisure-time physical activity level and white blood cell count, as well as neutrophil-to-lymphocyte ratio, suggesting that higher levels of physical activity may lead to lower levels of inflammation, which could be important for future chronic disease outcomes.
SPORTS MEDICINE-OPEN
(2023)
Review
Cardiac & Cardiovascular Systems
Muataz Ali Hamad, Krystin Krauel, Nancy Schanze, Nadine Gauchel, Peter Stachon, Thomas Nuehrenberg, Mark Zurek, Daniel Duerschmied
Summary: In addition to their role in hemostasis and thrombosis, platelets also play a role in modulating inflammatory reactions and immune responses. Circulating platelets can differ within an individual due to their different physical properties and can be categorized into distinct subtypes based on their function or age. Understanding platelet phenotypic variation is important in various physiological and pathological circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
Carme Gubern-Merida, Pau Comajoan, Gemma Huguet, Isaac Garcia-Yebenes, Ignacio Lizasoain, Maria Angeles Moro, Irene Puig-Parnau, Juan Manuel Sanchez, Joaquin Serena, Elisabet Kadar, Mar Castellanos
Summary: Thrombolytic therapy with rt-PA is currently the only FDA-approved drug for acute ischemic stroke, but its use is limited due to the risk of hemorrhagic transformation. This study investigates the expression of Cav-1 and its relationship with rt-PA in ischemic conditions. The results show contradictory effects of rt-PA on Cav-1 expression in different experimental models. Delayed administration of rt-PA reduces Cav-1 levels and correlates with hemorrhage volume after infarction.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Macarena Hernandez-Jimenez, Samuel Martin-Vilchez, Dolores Ochoa, Gina Mejia-Abril, Manuel Roman, Paola Camargo-Mamani, Sergio Luquero-Bueno, Bernd Jilma, Maria A. Moro, Geronimo Fernandez, David Pineiro, Marc Ribo, Victor M. Gonzalez, Ignacio Lizasoain, Francisco Abad-Santos
Summary: This study characterized the safety and pharmacokinetics of ApTOLL in healthy volunteers and found that it has excellent safety and adequate pharmacokinetic profile.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Pharmacology & Pharmacy
Agustin Clemente-Moragon, Eduardo Oliver, Daniel Calle, Lorena Cusso, Monica Gomez, Jesus M. Pradillo, Raquel Castejon, Norma Rallon, Jose M. Benito, Jose C. Fernandez-Ferro, Joaquin Carneado-Ruiz, Maria A. Moro, Javier Sanchez-Gonzalez, Valentin Fuster, Marta Cortes-Canteli, Manuel Desco, Borja Ibanez
Summary: By targeting neutrophil beta(1) adrenoceptors (beta 1AR), cerebral damage in patients with ischaemic stroke can be improved, providing a novel therapeutic strategy.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Clinical Neurology
Steffen Tiedt, Alastair M. Buchan, Martin Dichgans, Ignacio Lizasoain, Maria A. Moro, Eng H. Lo
Summary: The article discusses the pathophysiology of ischemic stroke, emphasizing the interaction between the neurovascular unit and systemic biology. It explores the potential of this integrated view in discovering new mechanisms and improving stroke care.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Clinical Neurology
Elga Esposito, Fang Zhang, Ji-Hyun Park, Emiri T. Mandeville, Wenlu Li, Maria Isabel Cuartero, Ignacio Lizasoain, Maria A. Moro, Eng H. Lo
Summary: This study compares the immune response during the active/awake phase versus inactive/sleep phase in a mouse model of transient focal cerebral ischemia. The results indicate that there are significant diurnal effects on the immune response after ischemia, with higher levels of T cells in blood during the sleep phase and increased infiltration of activated T cells into the brain.
Article
Engineering, Biomedical
Patricia Martinez-Miguel, Rocio Gimena Munoz, Marta Barrionuevo Gonzalez, Susana Lopez-Ongil, Maria Angeles Moro, Ignacio Lizasoain, Diego Rodriguez-Puyol, Juan Manuel Garcia Segura
Summary: This study compares the efficacy and safety of OL-HDF with two MCO dialyzers.
Article
Medicine, Research & Experimental
Marta Paz-Garcia, Adrian Povo-Retana, Rafael I. Jaen, Patricia Prieto, Diego A. Peraza, Carlos Zaragoza, Macarena Hernandez-Jimenez, David Pineiro, Javier Regadera, Maria L. Garcia-Bermejo, E. Macarena Rodriguez-Serrano, Sergio Sanchez-Garcia, Maria A. Moro, Ignacio Lizasoain, Carmen Delgado, Carmen Valenzuela, Lisardo Bosca
Summary: Experimental evidence suggests that controlling the inflammatory response is crucial in reducing cardiac injury after myocardial infarction. An aptamer called 4FT has been investigated for its selective antagonistic effects on human TLR4 in macrophages and a rat model of cardiac ischemia/reperfusion. Treatment with 4FT significantly inhibits TLR4 signaling and improves cardiac injury and markers in the rat model. The expression of inflammatory genes is reduced, while anti-inflammatory genes and pro-resolution molecules are enhanced after 4FT administration, indicating its potential as a therapeutic strategy for preventing cardiac dysfunction after infarction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Raquel Toribio-Fernandez, Carlos Ceron, Catarina Tristao-Pereira, Irene Fernandez-Nueda, Ana Perez-Castillo, Jose Fernandez-Ferro, Maria Angeles Moro, Borja Ibanez, Valentin Fuster, Marta Cortes-Canteli
Summary: Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated, with similar risk factors and vascular components. Clinical studies suggest that anticoagulants, particularly direct oral anticoagulants, may decrease the incidence of dementia in patients with CVD. However, more research is needed to understand the differential effects on different types of dementia and determine the best drug and strategy for prevention and treatment of AD.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Wenlu Li, Emiri T. Mandeville, Violeta Duran-Laforet, Norito Fukuda, Zhanyang Yu, Yi Zheng, Aaron Held, Ji-Hyun Park, Takafumi Nakano, Masayoshi Tanaka, Jingfei Shi, Elga Esposito, Wanting Niu, Changhong Xing, Kazuhide Hayakawa, Ignacio Lizasoain, Klaus van Leyen, Xunming Ji, Brian J. Wainger, Maria A. Moro, Eng H. Lo
Summary: The concept of the neurovascular unit highlights the importance of cell-cell signaling between neural, glial, and vascular compartments. Research has found that brain endothelial cells may release trans-differentiation signals to convert astrocytes into neural progenitor cells after stroke.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jeffrey B. Saver, Elizabeth M. Klerman, Alastair Buchan, Patricia Calleja, Ignacio Lizasoain, Mersedeh Bahr-Hosseini, Sarah S. Lee, David Liebeskind, Philipp T. Mergenthaler, Katherine Mun, MingMing Ning, David Pelz, David M. Ray, Peter Rothwell, Pierre Seners, Anirudh Sreekrishnan, Eleanor Mina Sung, Steffen Tiedt, Alastair J. S. Webb, Teresa W. Woelfer, Gregory Albers
Summary: There is increasing evidence that circadian and diurnal rhythms have a strong influence on stroke onset, mechanism, progression, recovery, and response to therapy. To enhance our understanding, standardized definitions and coding guides for data collection are needed, as well as advanced imaging techniques and large data registries. The development of standardized data structures will aid researchers in studying the impact of circadian/diurnal biology on stroke.
Article
Clinical Neurology
Macarena Hernandez-Jimenez, Francisco Abad-Santos, Ian Cotgreave, Jaime Gallego, Bernd Jilma, Alan Flores, Tudor G. Jovin, Jose Vivancos, Maria Hernandez-Perez, Carlos A. Molina, Joan Montaner, Joaquin Casariego, Mads Dalsgaard, David S. Liebeskind, Erik Cobo, Mar Castellanos, Pere Cardona Portela, Jaime Masjuan, Francisco Moniche, Jose Ignacio Tembl, Mikel Terceno Izaga, Juan F. Arenillas, Patricia Callejas, Jean Marc Olivot, Lionel Calviere, Hilde Henon, Mikael Mazighi, David Pineiro, Marco Pugliese, Victor M. Gonzalez, Maria Angeles Moro, Alvaro Garcia-Tornel, Ignacio Lizasoain, Marc Ribo
Summary: The study aimed to assess the safety and efficacy of ApTOLL in combination with endovascular treatment (EVT) for patients with ischemic stroke. The results showed that administering 0.2 mg/kg of ApTOLL within 6 hours in combination with EVT was safe and associated with a reduction in mortality and disability at 90 days compared with placebo.
Article
Clinical Neurology
Macarena Hernandez-Jimenez, Francisco Abad-Santos, Ian Cotgreave, Jaime Gallego, Bernd Jilma, Alan Flores, Tudor G. Jovin, Jose Vivancos, Carlos A. Molina, Joan Montaner, Joaquin Casariego, Mads Dalsgaard, Maria Hernandez-Perez, David S. Liebeskind, Erik Cobo, Marc Ribo
Summary: In the reperfusion era, the combination of endovascular treatment (EVT) and neuroprotective drugs, such as ApTOLL, is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). ApTOLL, a Toll-like receptor 4 (TLR4) antagonist, has shown neuroprotective effects in preclinical models and has a favorable pharmacokinetic and safety profile. This clinical trial, called APRIL, aims to assess the tolerability, safety, pharmacokinetics, and biological effect of ApTOLL in AIS patients eligible for EVT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jesus M. Pradillo, Alicia Garcia-Culebras, M. Isabel Cuartero, Carolina Pena-Martinez, M. Angeles Moro, Ignacio Lizasoain, Ana Moraga
Summary: This article reviews the platforms and models commonly used in recent years to study the pathophysiology of ischaemic stroke, including in vitro and in vivo experimental models. The ultimate aim is to find new forms of treatment to improve patients' prognosis and quality of life.
REVISTA DE NEUROLOGIA
(2022)