Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection

(2022) Kevin O. Saunders et al.   Science Translational Medicine

Progress toward improved understanding of antibody maturation

(2021) Sandor Vajda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

(2021) Kevin O. Saunders et al.   NATURE

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

(2021) Olivia Swanson et al.   Cell Reports

Strategies for eliciting multiple lineages of broadly neutralizing antibodies to HIV by vaccination

(2021) Zekun Mu et al.   Current Opinion in Virology

To bnAb or Not to bnAb: Defining Broadly Neutralising Antibodies Against HIV-1

(2021) Sarah A. Griffith et al.   Frontiers in Immunology

Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention

(2020) Kathryn E. Stephenson et al.   Annual Review of Immunology

Targeting the N332-supersite of the HIV-1 envelope for vaccine design

(2020) Thandeka Moyo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage

(2020) Jeffrey O. Zhou et al.   Frontiers in Immunology

HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite

(2020) Bartek Nogal et al.   Science Advances

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

(2019) Rory Henderson et al.   Nature Communications

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

(2019) Amelia Escolano et al.   NATURE

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

(2019) Jon M. Steichen et al.   SCIENCE

Affinity maturation in a human humoral response to influenza hemagglutinin

(2019) Kevin R. McCarthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

(2019) Kevin O. Saunders et al.   SCIENCE

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

(2018) Kevin Wiehe et al.   Cell Host & Microbe

Atomic Resolution Cryo-EM Structure of β-Galactosidase

(2018) Alberto Bartesaghi et al.   STRUCTURE

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

(2018) Daniela Fera et al.   Nature Communications

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps

(2018) Tristan Ian Croll   Acta Crystallographica Section D-Structural Biology

Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing

(2018) Arjun K. Mishra et al.   Frontiers in Immunology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope

(2017) Colin Anthony et al.   JOURNAL OF VIROLOGY

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

(2017) Mattia Bonsignori et al.   Science Translational Medicine

Novel Approaches to Analyze Immunoglobulin Repertoires

(2017) Hedda Wardemann et al.   TRENDS IN IMMUNOLOGY

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

(2017) Alba Torrents de la Peña et al.   Cell Reports

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

(2016) Mattia Bonsignori et al.   CELL

HIV-Host Interactions: Implications for Vaccine Design

(2016) Barton F. Haynes et al.   Cell Host & Microbe

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Insights into the trimeric HIV-1 envelope glycoprotein structure

(2015) Andrew B. Ward et al.   TRENDS IN BIOCHEMICAL SCIENCES

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Affinity Enhancement of Antibodies: How Low-Affinity Antibodies Produced Early in Immune Responses Are Followed by High-Affinity Antibodies Later and in Memory B-Cell Responses

(2014) H. N. Eisen   Cancer Immunology Research

Broadly neutralizing antibodies against influenza viruses

(2013) Nick S. Laursen et al.   ANTIVIRAL RESEARCH

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

(2013) Florian Klein et al.   CELL

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

(2012) A. G. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY