ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS

Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

(2022) Mukesh Gautam et al.   Scientific Reports

Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson's Disease

(2022) Loredana Leggio et al.   Advanced Healthcare Materials

α-Synuclein A53T Promotes Mitochondrial Proton Gradient Dissipation and Depletion of the Organelle Respiratory Reserve in a Neuroblastoma Cell Line

(2022) Pierpaolo Risiglione et al.   Life-Basel

The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity

(2021) Michele Frison et al.   MOLECULAR PSYCHIATRY

Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: Target inhibitors and influences on neurological dysfunctions

(2021) Rakesh Sahu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Small Hexokinase 1 Peptide against Toxic SOD1 G93A Mitochondrial Accumulation in ALS Rescues the ATP-Related Respiration

(2021) Andrea Magrì et al.   Biomedicines

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Amyotrophic lateral sclerosis: a clinical review

(2020) P. Masrori et al.   EUROPEAN JOURNAL OF NEUROLOGY

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells

(2020) Philippe Marchetti et al.   FASEB JOURNAL

High-Resolution Respirometry Reveals MPP+ Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson’s Disease

(2020) Pierpaolo Risiglione et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging

(2020) Sonia Lavisse et al.   PARKINSONISM & RELATED DISORDERS

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants

(2019) Jisen Huai et al.   Frontiers in Neurology

Parkin expression reverses mitochondrial dysfunction in fused in sarcoma‐induced amyotrophic lateral sclerosis

(2019) S. J. Cha et al.   INSECT MOLECULAR BIOLOGY

Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques

(2019) Mehdi A. J. van den Bos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients

(2019) Joy Mitra et al.   Molecular Brain

Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

(2019) Maria Pannell et al.   GLIA

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

(2019) Rita Mejzini et al.   Frontiers in Neuroscience

Interactions of VDAC with Proteins Involved in Neurodegenerative Aggregation: An Opportunity for Advancement on Therapeutic Molecules

(2018) Andrea Magri et al.   CURRENT MEDICINAL CHEMISTRY

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Functional Mitochondria in Health and Disease

(2017) Patries M. Herst et al.   Frontiers in Endocrinology

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

(2016) Brittany M. Edens et al.   Frontiers in Cellular Neuroscience

Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability

(2016) Andrea Magrì et al.   Scientific Reports

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS

(2016) Daniel Cacabelos et al.   Acta Neuropathologica Communications

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide

(2015) M. L. James et al.   JOURNAL OF NUCLEAR MEDICINE

Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice

(2015) Yuxiang Xie et al.   NEURON

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

A TSPO ligand is protective in a mouse model of multiple sclerosis

(2013) Daniel J. Daugherty et al.   EMBO Molecular Medicine

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons

(2012) J. Magrane et al.   JOURNAL OF NEUROSCIENCE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line

(2012) Kun Hong et al.   NEUROSCIENCE LETTERS

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS

(2011) Victòria Ayala et al.   ACTA NEUROPATHOLOGICA

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

G37R SOD1 mutant alters mitochondrial complex I activity, Ca2+ uptake and ATP production

(2011) Evelyne Coussee et al.   CELL CALCIUM

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Protein Kinase Cε Regulation of Translocator Protein (18 kDa)TspoGene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors

(2010) Amani Batarseh et al.   BIOCHEMISTRY

Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation

(2010) Antonella Caccamo et al.   Molecular Neurodegeneration

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities

(2009) J. Magrane et al.   HUMAN MOLECULAR GENETICS

Capacity of oxidative phosphorylation in human skeletal muscle

(2009) Erich Gnaiger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

(2008) C. Vande Velde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA