Deoxyschizandrin ameliorates obesity and non‐alcoholic fatty liver disease: Involvement of dual Farnesyl X receptor/G protein‐coupled bile acid receptor 1 activation and leptin sensitization

The role of sugar-sweetened beverages in the global epidemics of obesity and chronic diseases

(2022) Vasanti S. Malik et al.   Nature Reviews Endocrinology

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

(2022) Kiarash Riazi et al.   Lancet Gastroenterology & Hepatology

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

(2021) Lulu Sun et al.   Nature Reviews Gastroenterology & Hepatology

Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors

(2021) Marica Cariello et al.   Cellular and Molecular Gastroenterology and Hepatology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Hypothalamic bile acid-TGR5 signaling protects from obesity

(2021) Ashley Castellanos-Jankiewicz et al.   Cell Metabolism

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

Bile acids and their receptors in metabolic disorders

(2021) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists

(2021) Sachiho Miyata et al.   Scientific Reports

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

(2021) Bethan L. Clifford et al.   Cell Metabolism

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

(2021) Daniel Ferguson et al.   Nature Reviews Endocrinology

Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease

(2021) Rui Xue et al.   Cells

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy

(2020) John Y. L. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The effect of deoxyschizandrin on chronic unpredictable mild stress–induced depression

(2020) Xinfei Ma et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extract of Schisandra chinensis fruit protects against metabolic dysfunction in high‐fat diet induced obese mice via FXR activation

(2020) Ming Gu et al.   PHYTOTHERAPY RESEARCH

Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

(2020) Yuan Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Schizandrin A supplementation improves non-alcoholic fatty liver disease in mice fed a high-fat and high-cholesterol diet

(2019) Mi Ji Jeong et al.   NUTRITION RESEARCH

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Schisandrin A ameliorates MPTP-induced Parkinson’s disease in a mouse model via regulation of brain autophagy

(2019) Yinghao Zhi et al.   ARCHIVES OF PHARMACAL RESEARCH

Obesity: a neuroimmunometabolic perspective

(2019) Chelsea M. Larabee et al.   Nature Reviews Endocrinology

INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function

(2018) Paolo Comeglio et al.   JOURNAL OF ENDOCRINOLOGY

Leptin and the maintenance of elevated body weight

(2018) Warren W. Pan et al.   NATURE REVIEWS NEUROSCIENCE

Leptin and brain–adipose crosstalks

(2018) Alexandre Caron et al.   NATURE REVIEWS NEUROSCIENCE

Hypothalamic Sensing of Bile Acids, a Gut Feeling

(2018) Allison W. Xu   TRENDS IN ENDOCRINOLOGY AND METABOLISM

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

(2018) Jonathan D Roth et al.   WORLD JOURNAL OF GASTROENTEROLOGY

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

(2018) Laura A. Velazquez-Villegas et al.   Nature Communications

A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

(2018) Shunmei Liu et al.   Molecular Metabolism

Small molecules for fat combustion: targeting obesity

(2018) Jingxin Liu et al.   Acta Pharmaceutica Sinica B

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cellular and molecular bases of leptin and ghrelin resistance in obesity

(2017) Huxing Cui et al.   Nature Reviews Endocrinology

Clinical relevance of the bile acid receptor TGR5 in metabolism

(2017) F Samuel van Nierop et al.   Lancet Diabetes & Endocrinology

Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release

(2016) Yuanzhong Xu et al.   DIABETES

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

(2016) Jaemin Lee et al.   NATURE MEDICINE

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation

(2015) Yiming Jiang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Sexually Dimorphic Genome-Wide Binding of Retinoid X Receptor alpha (RXRα) Determines Male-Female Differences in the Expression of Hepatic Lipid Processing Genes in Mice

(2013) Astrid Kosters et al.   PLoS One

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis

(2011) Xuemei Ge et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

(2009) Songwen Zhang et al.   JOURNAL OF HEPATOLOGY

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

(2009) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY