The cellular and molecular bases of leptin and ghrelin resistance in obesity

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

(2016) Arash Yavari et al.   Cell Metabolism

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

(2016) Bharath K. Mani et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

(2016) Jeffrey M. Zigman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane

(2016) Deng-Fu Guo et al.   PLoS Genetics

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Diet-Induced Obese Mice Retain Endogenous Leptin Action

(2015) Nickki Ottaway et al.   Cell Metabolism

Roles of leptin in bone metabolism and bone diseases

(2015) Xu Xu Chen et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Neonatal ghrelin programs development of hypothalamic feeding circuits

(2015) Sophie M. Steculorum et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation

(2015) Farhana Naznin et al.   JOURNAL OF ENDOCRINOLOGY

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

(2015) K. C. G. de Git et al.   Obesity Reviews

Diet-induced obesity causes ghrelin resistance in reward processing tasks

(2015) Sarah H. Lockie et al.   PSYCHONEUROENDOCRINOLOGY

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin

(2015) Gustav Collden et al.   Molecular Metabolism

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Protein tyrosine phosphatases as potential therapeutic targets

(2014) Rong-jun He et al.   ACTA PHARMACOLOGICA SINICA

Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia

(2014) Frederick A. Kweh et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Leptin Mediates the Increase in Blood Pressure Associated with Obesity

(2014) Stephanie E. Simonds et al.   CELL

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

(2014) Garron T. Dodd et al.   Cell Metabolism

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Review of Novel Aspects of the Regulation of Ghrelin Secretion

(2014) Omar Massadi et al.   CURRENT DRUG METABOLISM

Hypothalamic mTOR: The Rookie Energy Sensor

(2014) P. Martínez de Morentin et al.   CURRENT MOLECULAR MEDICINE

Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice

(2014) Dana I. Briggs et al.   ENDOCRINOLOGY

Obesity-Associated Hypertension

(2014) Kamal Rahmouni   HYPERTENSION

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: Implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression

(2014) Shunsuke Koga et al.   NEUROBIOLOGY OF DISEASE

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass

(2014) Aki Uchida et al.   Molecular Metabolism

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

(2014) Kavon Rezai-Zadeh et al.   Molecular Metabolism

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor

(2014) Ryan C. Tsou et al.   Molecular Metabolism

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

Selective leptin resistance revisited

(2013) Allyn L. Mark   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects

(2013) Shannon M. Harlan et al.   Cell Metabolism

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

(2013) K. M. Heppner et al.   DIABETES

Calorie-Restricted Weight Loss Reverses High-Fat Diet-Induced Ghrelin Resistance, Which Contributes to Rebound Weight Gain in a Ghrelin-Dependent Manner

(2013) Dana I. Briggs et al.   ENDOCRINOLOGY

The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release

(2013) Blerina Kola et al.   FASEB JOURNAL

Effects of Neonatal Programming on Hypothalamic Mechanisms Controlling Energy Balance

(2013) C. Contreras et al.   HORMONE AND METABOLIC RESEARCH

Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity

(2013) Bhavaani Jayaram et al.   JOURNAL OF APPLIED PHYSIOLOGY

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

(2013) Darko Stevanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

(2013) Amparo Romero-Picó et al.   NEUROPSYCHOPHARMACOLOGY

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei

(2013) Su Gao et al.   PHYSIOLOGY & BEHAVIOR

Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin

(2013) Amparo Romero-Picó et al.   PSYCHOPHARMACOLOGY

Nutritional programming of insulin resistance: causes and consequences

(2013) Daniella E. Duque-Guimarães et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Leptin signaling and circuits in puberty and fertility

(2012) Carol F. Elias et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice

(2012) Ryan C. Tsou et al.   ENDOCRINOLOGY

MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

(2012) Patric J D Delhanty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism

(2012) Chung Thong Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

(2012) Kevin W Williams et al.   NATURE NEUROSCIENCE

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

From muscle wasting to sarcopenia and myopenia: update 2012

(2012) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

The obesity paradox in chronic disease: facts and numbers

(2012) Mitja Lainscak et al.   Journal of Cachexia Sarcopenia and Muscle

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

(2011) Makoto Fukuda et al.   Cell Metabolism

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

(2011) Gina M. Leinninger et al.   Cell Metabolism

Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner

(2011) Liat Rousso-Noori et al.   Cell Metabolism

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

Ghrelin-induced adiposity is independent of orexigenic effects

(2011) Diego Perez-Tilve et al.   FASEB JOURNAL

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain

(2011) Mario Perello et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task

(2011) Beate C. Finger et al.   PSYCHOPHARMACOLOGY

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons

(2010) Dana I. Briggs et al.   ENDOCRINOLOGY

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

The Hyperphagic Effect of Ghrelin Is Inhibited in Mice by a Diet High in Fat

(2010) James V. Gardiner et al.   GASTROENTEROLOGY

Identification and Functional Analysis of Novel Human Growth Hormone Secretagogue Receptor (GHSR) Gene Mutations in Japanese Subjects with Short Stature

(2010) Hiroshi Inoue et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of Ghrelin and Growth Hormone Deficiency on AMP-Activated Protein Kinase and Hypothalamic Lipid Metabolism

(2010) S. Sangiao-Alvarellos et al.   JOURNAL OF NEUROENDOCRINOLOGY

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance

(2010) A. A. Pierce et al.   JOURNAL OF NEUROSCIENCE

Metabolic Status Regulates Ghrelin Function on Energy Homeostasis

(2010) Dana I. Briggs et al.   NEUROENDOCRINOLOGY

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress

(2010) Pablo Blanco Martínez de Morentin et al.   PLOS BIOLOGY

Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia

(2010) Timo D. Müller et al.   Journal of Cachexia Sarcopenia and Muscle

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Central Ghrelin Regulates Peripheral Lipid Metabolism in a Growth Hormone-Independent Fashion

(2009) Susana Sangiao-Alvarellos et al.   ENDOCRINOLOGY

Tat-modified Leptin is more Accessible to Hypothalamus through Brain-blood Barrier with a Significant Inhibition of Body-weight Gain in High-fat-diet Fed Mice

(2009) C. Zhang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor

(2009) Jacques Pantel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy

(2009) Susan T. Stewart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms mediating renal sympathetic activation to leptin in obesity

(2008) Donald A. Morgan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Leptin beyond body weight regulation—Current concepts concerning its role in immune function and inflammation

(2008) Rocío Lago et al.   CELLULAR IMMUNOLOGY

Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice

(2008) Weihong Pan et al.   ENDOCRINOLOGY

Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability

(2008) Ruben Nogueiras et al.   ENDOCRINOLOGY

Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome

(2008) Kathleen De Waele et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperghrelinemia Precedes Obesity in Prader-Willi Syndrome

(2008) Eva Feigerlová et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

(2008) Jianhua Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa

(2008) C Ruth González et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents

(2008) Peter Kobelt et al.   PEPTIDES

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood–brain barrier

(2008) William A. Banks et al.   PEPTIDES

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

(2007) Paul T. Pfluger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY