The antidepressant actions of ketamine and its enantiomers

NMDA RECEPTOR ACTIVATION-DEPENDENT ANTIDEPRESSANT-RELEVANT BEHAVIORAL AND SYNAPTIC ACTIONS OF KETAMINE

(2023) Panos Zanos et al.   JOURNAL OF NEUROSCIENCE

Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach

(2023) Ellen Scotton et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile

(2023) Jenessa N. Johnston et al.   DRUG DISCOVERY TODAY

Sex and Estrous Cycle Are Not Mediators of S-Ketamine’s Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression

(2023) Shokouh Arjmand et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Arketamine as adjunctive therapy for treatment-resistant depression: A placebo-controlled pilot study

(2023) Gustavo C. Leal et al.   JOURNAL OF AFFECTIVE DISORDERS

Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment

(2023) Jenessa N. Johnston et al.   NEUROPHARMACOLOGY

S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats

(2022) Xianlin Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Systematic Review of Circulatory microRNAs in Major Depressive Disorder: Potential Biomarkers for Disease Prognosis

(2022) Madiha Rasheed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans

(2022) Jaclyn N Highland et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.

(2022) Guang Chen et al.   MOLECULAR PSYCHIATRY

Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial

(2022) Chadi G. Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

Response to Intravenous Racemic Ketamine After Switch From Intranasal (S)‐ketamine on Symptoms of Treatment‐Resistant Depression and PTSD in Veterans: a Retrospective Case Series

(2022) S. Bentley et al.   PHARMACOTHERAPY

S-ketamine as an adjuvant in patient-controlled intravenous analgesia for preventing postpartum depression: a randomized controlled trial

(2022) Yaqian Han et al.   BMC Anesthesiology

Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine

(2022) Li Ma et al.   Translational Psychiatry

Combined Administration of (R)-Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB/BDNF-Dependent Mechanism

(2022) Anna Rafało-Ulińska et al.   Pharmaceuticals

A New Player in Depression: MiRNAs as Modulators of Altered Synaptic Plasticity

(2022) Ya-Nan Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice

(2022) Alessia Mastrodonato et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis

(2022) Yazen Alnefeesi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The effect of ketamine on anhedonia: improvements in dimensions of anticipatory, consummatory, and motivation-related reward deficits

(2022) Danica Nogo et al.   PSYCHOPHARMACOLOGY

Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

(2022) Igor D. Bandeira et al.   HARVARD REVIEW OF PSYCHIATRY

Evaluation of the Trajectory of Depression Severity With Ketamine and Esketamine Treatment in a Clinical Setting

(2022) Sina Nikayin et al.   JAMA Psychiatry

The abuse liability of ketamine: A scoping review of preclinical and clinical studies

(2022) Tuyen T. Le et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2

(2022) Juan Pablo Lopez et al.   NEURON

Ketamine as a prophylactic resilience-enhancing agent

(2022) Audrey G. Evers et al.   Frontiers in Psychiatry

Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites

(2022) Yukio Ago et al.   NEUROPHARMACOLOGY

A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model

(2022) Li Ma et al.   NEUROPHARMACOLOGY

Ketamine; history and role in anesthetic pharmacology

(2022) Kazuyoshi Hirota et al.   NEUROPHARMACOLOGY

A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice

(2022) Li Ma et al.   Translational Psychiatry

Real-world experience of esketamine use to manage treatment-resistant depression: A multicentric study on safety and effectiveness (REAL-ESK study)

(2022) Giovanni Martinotti et al.   JOURNAL OF AFFECTIVE DISORDERS

Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine

(2022) Satoshi Deyama et al.   NEUROPHARMACOLOGY

A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults

(2022) Sara Costi et al.   Neurobiology of Stress

Effect of Intraoperative Esketamine Infusion on Postoperative Sleep Disturbance After Gynecological Laparoscopy

(2022) Di Qiu et al.   JAMA Network Open

Impact of Repeated Doses of Subcutaneous Esketamine on Acute Dissociative Symptoms in Treatment-Resistant Depression

(2022) Lorena Catarina Del Sant et al.   Pharmaceuticals

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder

(2021) Adriana Feder et al.   AMERICAN JOURNAL OF PSYCHIATRY

Ketamine-induced urological toxicity: potential mechanisms and translation for adults with mood disorders receiving ketamine treatment

(2021) Jason Ng et al.   PSYCHOPHARMACOLOGY

Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (R)-ketamine, but not (S)-ketamine: A role of TrkB signaling

(2021) Yuko Fujita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability

(2021) Jordi Bonaventura et al.   MOLECULAR PSYCHIATRY

Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders

(2021) Felicia Ceban et al.   CNS DRUGS

(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation

(2021) Jiancheng Zhang et al.   PSYCHOPHARMACOLOGY

A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action

(2021) Pei-Yi Lin et al.   Cell Reports

Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged‐Release Ketamine With Emphasis on 2,6‐Hydroxynorketamines

(2021) Michael Weiss et al.   Clinical Pharmacology in Drug Development

The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice

(2021) Anna Rafało-Ulińska et al.   BEHAVIOURAL BRAIN RESEARCH

Efficacy and safety of fixed doses of intranasal Esketamine as an add-on therapy to Oral antidepressants in Japanese patients with treatment-resistant depression: a phase 2b randomized clinical study

(2021) Nagahide Takahashi et al.   BMC Psychiatry

The resilient phenotype elicited by ketamine against inflammatory stressors-induced depressive-like behavior is associated with NLRP3-driven signaling pathway

(2021) Anderson Camargo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

(2021) Wei Yao et al.   MOLECULAR PSYCHIATRY

Intravenous arketamine for treatment-resistant depression: open-label pilot study

(2020) Gustavo C. Leal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

(2R,6R)-Hydroxynorketamine (HNK) plasma level predicts poor antidepressant response: is this the end of the HNK pipeline?

(2020) Chadi G. Abdallah   NEUROPSYCHOPHARMACOLOGY

Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

(2020) Briana K. Chen et al.   NEUROPSYCHOPHARMACOLOGY

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression

(2020) Rei Yokoyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats

(2020) Piotr Popik et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

(2020) Paulo R. Shiroma et al.   Translational Psychiatry

Ketamine Pharmacokinetics

(2020) Jasper Kamp et al.   ANESTHESIOLOGY

Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis

(2020) Anees Bahji et al.   JOURNAL OF AFFECTIVE DISORDERS

A systematic review and meta-analysis of the efficacy of intravenous ketamine infusion for treatment resistant depression: January 2009 – January 2019

(2020) Walter S. Marcantoni et al.   JOURNAL OF AFFECTIVE DISORDERS

The role of dissociation in ketamine’s antidepressant effects

(2020) Elizabeth D. Ballard et al.   Nature Communications

Prophylactic use of ketamine reduces postpartum depression in Chinese women undergoing cesarean section

(2019) Jia-Hui Ma et al.   PSYCHIATRY RESEARCH

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

(2019) Eric W. Lumsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

(2019) Jennifer L. Phillips et al.   AMERICAN JOURNAL OF PSYCHIATRY

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study

(2019) Vanina Popova et al.   AMERICAN JOURNAL OF PSYCHIATRY

Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

(2019) Maggie Fedgchin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine

(2019) Lijia Chang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression

(2019) Ella J. Daly et al.   JAMA Psychiatry

Prophylactic (R,S)-ketamine selectively protects against inflammatory stressors

(2019) Alessia Mastrodonato et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study

(2019) Paul Glue et al.   JOURNAL OF PSYCHOPHARMACOLOGY

MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling

(2019) Atsuhiro Fujita et al.   PSYCHOPHARMACOLOGY

Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials

(2019) Katrina Witt et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study

(2019) Fernanda S. Correia-Melo et al.   JOURNAL OF AFFECTIVE DISORDERS

Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression

(2019) Elia E. Acevedo-Diaz et al.   JOURNAL OF AFFECTIVE DISORDERS

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites

(2019) Chun Yang et al.   Translational Psychiatry

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

(2019) Yunfei Tan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis

(2018) Samuel T. Wilkinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study

(2018) Carla M. Canuso et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

(2018) Jennifer L. Jones et al.   Frontiers in Psychiatry

History of anaesthesia

(2017) Georges Mion   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model

(2017) Kai Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Acute ketamine administration corrects abnormal inflammatory bone markers in major depressive disorder

(2017) B Kadriu et al.   MOLECULAR PSYCHIATRY

Effects of a ketamine metabolite on synaptic NMDAR function

(2017) Kanzo Suzuki et al.   NATURE

TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

(2017) Zhenzhong Ma et al.   Nature Communications

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression

(2017) Xinnan Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

(2016) Lesley K. Rao et al.   ANESTHESIOLOGY

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

A REVIEW OF KETAMINE ABUSE AND DIVERSION

(2016) Sean Sassano-Higgins et al.   DEPRESSION AND ANXIETY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

(2016) Oliver H. Miller et al.   NEUROPHARMACOLOGY

Assessing anhedonia in depression: Potentials and pitfalls

(2016) Sakina J. Rizvi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Single-dose infusion ketamine and non-ketamine N-methyl-d-aspartate receptor antagonists for unipolar and bipolar depression: a meta-analysis of efficacy, safety and time trajectories

(2016) T. Kishimoto et al.   PSYCHOLOGICAL MEDICINE

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade

(2014) Elena Nosyreva et al.   Frontiers in Molecular Neuroscience

Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)

(2013) Georges Mion et al.   CNS Neuroscience & Therapeutics

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

(2012) Zeruesenay Desta et al.   XENOBIOTICA

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Taming the Ketamine Tiger

(2010) Edward F. Domino   ANESTHESIOLOGY

Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro

(2010) Simone Portmann et al.   JOURNAL OF CHROMATOGRAPHY A

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

S(+)-ketamine Effect on Experimental Pain and Cardiac Output

(2009) Marnix Sigtermans et al.   ANESTHESIOLOGY

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS