The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice

The group II mGlu receptor antagonist LY341495 induces a rapid antidepressant-like effect and enhances the effect of ketamine in the chronic unpredictable mild stress model of depression in C57BL/6J mice

(2021) Agnieszka Pałucha-Poniewiera et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Intravenous arketamine for treatment-resistant depression: open-label pilot study

(2020) Gustavo C. Leal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice

(2020) Agnieszka Pałucha-Poniewiera et al.   BEHAVIOURAL PHARMACOLOGY

Antidepressant-like effects of ketamine in a mouse model of serotonergic dysfunction

(2020) Carey Wilson et al.   NEUROPHARMACOLOGY

( R )‐Ketamine exerts antidepressant actions partly via conversion to ( 2R,6R )‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

(2019) Panos Zanos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine

(2019) Lijia Chang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice

(2019) Sha-Sha Zhang et al.   PSYCHOPHARMACOLOGY

(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

(2019) Yukio Ago et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling

(2019) Atsuhiro Fujita et al.   PSYCHOPHARMACOLOGY

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling

(2019) Yunfei Tan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice

(2018) Karolina Podkowa et al.   NEUROPHARMACOLOGY

Antidepressant Potential of ( R )-Ketamine in Rodent Models: Comparison with ( S )-Ketamine

(2017) Kenichi Fukumoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model

(2017) Chun Yang et al.   Translational Psychiatry

Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

(2016) Kenji Hashimoto et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Ketamine: 50 Years of Modulating the Mind

(2016) Linda Li et al.   Frontiers in Human Neuroscience

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model

(2016) H-L Sun et al.   Translational Psychiatry

Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor

(2015) Kinga Sałat et al.   NEUROPHARMACOLOGY

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

(2015) Juanjuan Tang et al.   Scientific Reports

The translational study of apathy—an ecological approach

(2015) Flurin Cathomas et al.   Frontiers in Behavioral Neuroscience

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

(2013) Ji-chun Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Social vs. environmental stress models of depression from a behavioural and neurochemical approach

(2012) E. Venzala et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

(2012) Oguz Mutlu et al.   LIFE SCIENCES

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy

(2011) Anita J. Bechtholt-Gompf et al.   PSYCHOPHARMACOLOGY

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Measuring behavior in mice with chronic stress depression paradigm

(2009) Tatyana Strekalova et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey

(2008) Ipek Yalcin et al.   BEHAVIOURAL BRAIN RESEARCH