Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

(2021) Plinio C. Casarotto et al.   CELL

Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

(2021) Jaclyn N. Highland et al.   PHARMACOLOGICAL REVIEWS

Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)‐Hydroxy Norketamine

(2020) Shafiq Ur Rahman et al.   Proteomics Clinical Applications

Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression

(2020) Cristan A. Farmer et al.   NEUROPSYCHOPHARMACOLOGY

Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

(2020) Briana K. Chen et al.   NEUROPSYCHOPHARMACOLOGY

(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression

(2020) Rei Yokoyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeted mass spectrometry of ketamine and its metabolites cis-6-hydroxynorketamine and norketamine in human blood serum

(2020) Lisa Kurzweil et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma

(2020) Greg I. Elmer et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Separation of anaesthetic ketamine and its derivates in PAMAPTAC coated capillaries with tuneable counter-current electroosmotic flow

(2020) Petr Tůma et al.   TALANTA

Antidepressant actions of ketamine engage cell-specific translation via eIF4E

(2020) Argel Aguilar-Valles et al.   NATURE

Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

(2019) Maurizio Fava et al.   MOLECULAR PSYCHIATRY

(2R,6R)-hydroxynorketamine exerts mGlu2receptor-dependent antidepressant actions

(2019) Panos Zanos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

(2019) Eric W. Lumsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression

(2019) Marlene P. Freeman et al.   JOURNAL OF PSYCHIATRIC RESEARCH

( R )‐Ketamine exerts antidepressant actions partly via conversion to ( 2R,6R )‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

(2019) Panos Zanos et al.   BRITISH JOURNAL OF PHARMACOLOGY

(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism

(2019) Lace M. Riggs et al.   NEUROPSYCHOPHARMACOLOGY

Interaction of Sex and Age on the Dissociative Effects of Ketamine Action in Young Healthy Participants

(2019) B. Derntl et al.   Frontiers in Neuroscience

Ketamine metabolite pilot study in a suicidal depression trial

(2019) Michael F. Grunebaum et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Common Neurotransmission Recruited in ( R , S )-Ketamine and (2 R ,6 R )-Hydroxynorketamine–Induced Sustained Antidepressant-like Effects

(2018) Thu Ha Pham et al.   BIOLOGICAL PSYCHIATRY

Enantioselective capillary electrophoresis provides insight into the phase II metabolism of ketamine and its metabolites in vivo and in vitro

(2018) Friederike A. Sandbaumhüter et al.   ELECTROPHORESIS

OUP accepted manuscript

(2018)   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NMDAR-independent, cAMP-dependent antidepressant actions of ketamine

(2018) Nathan H. Wray et al.   MOLECULAR PSYCHIATRY

(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray

(2018) Dylan Chou et al.   NEUROPHARMACOLOGY

(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

(2018) Jun-ichi Yamaguchi et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Sex differences in the pharmacokinetics of low-dose ketamine in plasma and brain of male and female rats.

(2018) Samantha K Saland et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine

(2018) Jaclyn N Highland et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

(2018) Kenichi Fukumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine augmentation rapidly improves depression scores in inpatients with treatment-resistant bipolar depression

(2017) Janusz K. Rybakowski et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites

(2017) Patrick J. Morris et al.   ORGANIC LETTERS

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

(2016) Ambalika Sarkar et al.   BIOLOGICAL PSYCHIATRY

A REVIEW OF KETAMINE ABUSE AND DIVERSION

(2016) Sean Sassano-Higgins et al.   DEPRESSION AND ANXIETY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Sex Differences in Human and Animal Toxicology

(2016) Michael Gochfeld   TOXICOLOGIC PATHOLOGY

Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner

(2016) Samantha K. Saland et al.   Scientific Reports

The use of ketamine as an antidepressant: a systematic review and meta-analysis

(2015) Caoimhe M. Coyle et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Clinical Predictors of Ketamine Response in Treatment-Resistant Major Depression

(2014) Mark J. Niciu et al.   JOURNAL OF CLINICAL PSYCHIATRY

Sex differences in the antidepressant-like effects of ketamine

(2013) Nicole Carrier et al.   NEUROPHARMACOLOGY

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

(2012) Xiaochen Zhao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

(2012) Zeruesenay Desta et al.   XENOBIOTICA

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro

(2010) Simone Portmann et al.   JOURNAL OF CHROMATOGRAPHY A

A parallel chiral–achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome

(2010) Ruin Moaddel et al.   TALANTA

Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry

(2009) S. C. Turfus et al.   DRUG METABOLISM AND DISPOSITION

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Chromatographic assays of drug oxidation by human cytochrome P450 3A4

(2009) Christal D Sohl et al.   Nature Protocols

Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation

(2009) Taina Sten et al.   STEROIDS