Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged‐Release Ketamine With Emphasis on 2,6‐Hydroxynorketamines

Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

(2021) Samuel Kohtala   Pharmacological Reports

Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

(2021) Jaclyn N. Highland et al.   PHARMACOLOGICAL REVIEWS

Ketamine Pharmacokinetics

(2020) Jasper Kamp et al.   ANESTHESIOLOGY

Efficacy of the ketamine metabolite (2R,6R)-hydroxynorketamine in mice models of pain

(2019) Jeffrey S Kroin et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Pharmacokinetic and pharmacodynamic considerations for NMDA-receptor antagonist ketamine in the treatment of chronic neuropathic pain: an update of the most recent literature

(2019) Jasper Kamp et al.   Expert Opinion on Drug Metabolism & Toxicology

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

(2018) Thomas K. Henthorn et al.   ANESTHESIOLOGY

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

(2018) Panos Zanos et al.   PHARMACOLOGICAL REVIEWS

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection

(2017) Georg M. Fassauer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative chiral and achiral determination of ketamine and its metabolites by LC–MS/MS in human serum, urine and fecal samples

(2017) Mahmoud Hasan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Empirical models for fitting of oral concentration time curves with and without an intravenous reference

(2017) Michael Weiss   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing

(2015) Samuel Fanta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Rifampicin has a Profound Effect on the Pharmacokinetics of Oral S-Ketamine and Less on Intravenous S-Ketamine

(2014) Marko A. Peltoniemi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

What is hydroxynorketamine and what can it bring to neurotherapeutics?

(2014) Nagendra S Singh et al.   Expert Review of Neurotherapeutics

Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects

(2014) Thierry Wendling et al.   PHARMACEUTICAL RESEARCH

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

(2012) Xiaochen Zhao et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

(2012) Zeruesenay Desta et al.   XENOBIOTICA

Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration

(2011) Ingeborg Noppers et al.   ANESTHESIOLOGY

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

S(+)-ketamine Effect on Experimental Pain and Cardiac Output

(2009) Marnix Sigtermans et al.   ANESTHESIOLOGY