Rheumatoid Arthritis — Common Origins, Divergent Mechanisms

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis

(2022) Steven R. Ytterberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

(2022) Kazuyoshi Ishigaki et al.   NATURE GENETICS

Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial

(2022) Felice Rivellese et al.   NATURE MEDICINE

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression

(2022) Nida Meednu et al.   Cell Reports

Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial

(2022) Doortje I Krijbolder et al.   LANCET

Granzyme K + CD8 T cells form a core population in inflamed human tissue

(2022) A. Helena Jonsson et al.   Science Translational Medicine

ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts

(2022) Minglu Yan et al.   NATURE IMMUNOLOGY

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

(2022) Richard I. Ainsworth et al.   Nature Communications

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

(2021) Frances Humby et al.   LANCET

Why It Hurts

(2021) Priyanka Iyer et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission

(2021) Siri Lillegraven et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2021) Liana Fraenkel et al.   Arthritis & Rheumatology

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

(2021) Maria Faas et al.   IMMUNITY

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Osteoporosis in patients with rheumatoid arthritis: trends in the German National Database 2007–2017

(2020) Lisa Lindner et al.   RHEUMATOLOGY INTERNATIONAL

Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial

(2020) Elise van Mulligen et al.   ANNALS OF THE RHEUMATIC DISEASES

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

(2020) Dana E. Orange et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rheumatoid Arthritis: Pathogenesis, Prediction and Prevention – An Emerging Paradigm Shift

(2020) Kevin D. Deane et al.   Arthritis & Rheumatology

Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality

(2020) Burkhard Möller et al.   Frontiers in Immunology

Risk for Serious Infection With Low-Dose Glucocorticoids in Patients With Rheumatoid Arthritis

(2020) Michael D. George et al.   ANNALS OF INTERNAL MEDICINE

Infectious complications of rheumatoid arthritis and psoriatic arthritis during targeted and biological therapies: a viewpoint in 2020

(2020) Olivier Lortholary et al.   ANNALS OF THE RHEUMATIC DISEASES

Sex steroids and autoimmune rheumatic diseases: state of the art

(2020) Maurizio Cutolo et al.   Nature Reviews Rheumatology

Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients with Increased Inflammation

(2020) Brittany Weber et al.   Arthritis & Rheumatology

Affinity Maturation of the Anti–Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis

(2019) Sarah Kongpachith et al.   Arthritis & Rheumatology

Impact and timing of smoking cessation on reducing risk for rheumatoid arthritis among women in the Nurses’ Health Studies

(2019) Xinyi Liu et al.   ARTHRITIS CARE & RESEARCH

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

(2019) Xiaojian Shao et al.   Clinical Epigenetics

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Predictors of fatigue in rheumatoid arthritis

(2019) Katie L Druce et al.   RHEUMATOLOGY

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

(2019) Myles J. Lewis et al.   Cell Reports

Coronary microvascular dysfunction in rheumatoid arthritis compared to diabetes mellitus and association with all‐cause mortality

(2019) Katherine P. Liao et al.   ARTHRITIS CARE & RESEARCH

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

(2018) V. Michael Holers et al.   Nature Reviews Rheumatology

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

(2018) Bishuang Cai et al.   Science Signaling

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study

(2018) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

Dendritic cells, T cells and their interaction in rheumatoid arthritis

(2018) P. Wehr et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

(2018) Pierre-Antoine Juge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population

(2017) Ryan W. Gan et al.   RHEUMATOLOGY

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients

(2017) M. Kristen Demoruelle et al.   Arthritis & Rheumatology

Certolizumab pegol in combination with dose-optimised methotrexate in DMARD-naïve patients with early, active rheumatoid arthritis with poor prognostic factors: 1-year results from C-EARLY, a randomised, double-blind, placebo-controlled phase III study

(2016) P Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs

(2016) Camille P Figueiredo et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 update of the EULAR recommendations for the management of early arthritis

(2016) Bernard Combe et al.   ANNALS OF THE RHEUMATIC DISEASES

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

(2016) Rizi Ai et al.   Nature Communications

RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis

(2016) William O'Brien et al.   Arthritis & Rheumatology

NETosis as Source of Autoantigens in Rheumatoid Arthritis

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study

(2016) Anders J. Svendsen et al.   Frontiers in Immunology

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation

(2015) Lynett Danks et al.   ANNALS OF THE RHEUMATIC DISEASES

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

(2015) Elisa Corsiero et al.   ANNALS OF THE RHEUMATIC DISEASES

Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force

(2015) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Update on autoantibodies to modified proteins

(2015) René E.M. Toes et al.   CURRENT OPINION IN RHEUMATOLOGY

Association of HLA-DRB1 Haplotypes With Rheumatoid Arthritis Severity, Mortality, and Treatment Response

(2015) Sebastien Viatte et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A European chart review study on early rheumatoid arthritis treatment patterns, clinical outcomes, and healthcare utilization

(2015) Paul Emery et al.   RHEUMATOLOGY INTERNATIONAL

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

(2015) Rizi Ai et al.   Arthritis & Rheumatology

Seronegative and seropositive RA: alike but different?

(2014) Sofia Ajeganova et al.   Nature Reviews Rheumatology

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

(2013) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapies for Active Rheumatoid Arthritis after Methotrexate Failure

(2013) James R. O'Dell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis

(2013) M. J. H. de Hair et al.   Arthritis & Rheumatology

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis

(2011) Lars Klareskog et al.   SEMINARS IN IMMUNOLOGY

Tumour necrosis factor antagonist use and associated risk reduction of cardiovascular events among patients with rheumatoid arthritis

(2010) J. D. Greenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis

(2009) Nicole C Walsh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES