Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Authors
Keywords
-
Journal
NATURE MEDICINE
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-05-20
DOI
10.1038/s41591-022-01789-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial
- (2021) Frances Humby et al. LANCET
- Fibroblast pathology in inflammatory joint disease
- (2021) Lucy‐Jayne Marsh et al. IMMUNOLOGICAL REVIEWS
- Emerging roles for IL-6 family cytokines as positive and negative regulators of ectopic lymphoid structures
- (2021) David G. Hill et al. CYTOKINE
- EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update
- (2020) Josef S Smolen et al. ANNALS OF THE RHEUMATIC DISEASES
- B cells and tertiary lymphoid structures promote immunotherapy response
- (2020) Beth A. Helmink et al. NATURE
- M3C: Monte Carlo reference-based consensus clustering
- (2020) Christopher R. John et al. Scientific Reports
- Notch signalling drives synovial fibroblast identity and arthritis pathology
- (2020) Kevin Wei et al. NATURE
- Translating IL-6 biology into effective treatments
- (2020) Ernest H. Choy et al. Nature Reviews Rheumatology
- PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets
- (2020) Ashley M. Curran et al. Nature Reviews Rheumatology
- A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients
- (2020) Alessandra Nerviani et al. Frontiers in Immunology
- An approach for normalization and quality control for NanoString RNA expression data
- (2020) Arjun Bhattacharya et al. BRIEFINGS IN BIOINFORMATICS
- Transforming clinical trials in rheumatology: towards patient-centric precision medicine
- (2020) Costantino Pitzalis et al. Nature Reviews Rheumatology
- Predicting treatment response to IL6R blockers in rheumatoid arthritis
- (2020) Bako Nouri et al. RHEUMATOLOGY
- The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus
- (2020) Roberto Giacomelli et al. AUTOIMMUNITY REVIEWS
- Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
- (2019) Nicola Ferrari et al. Nature Communications
- Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients
- (2019) Frances Humby et al. ANNALS OF THE RHEUMATIC DISEASES
- Distinct fibroblast subsets drive inflammation and damage in arthritis
- (2019) Adam P. Croft et al. NATURE
- Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
- (2019) Fan Zhang et al. NATURE IMMUNOLOGY
- Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
- (2019) Myles J. Lewis et al. Cell Reports
- Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)
- (2019) Gloria Lliso-Ribera et al. ANNALS OF THE RHEUMATIC DISEASES
- B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure
- (2019) F. Rivellese et al. Arthritis & Rheumatology
- Defining refractory rheumatoid arthritis
- (2018) Maya H Buch ANNALS OF THE RHEUMATIC DISEASES
- Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
- (2018) Fumitaka Mizoguchi et al. Nature Communications
- Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation
- (2018) William Stephenson et al. Nature Communications
- Rheumatoid arthritis
- (2018) Josef S. Smolen et al. Nature Reviews Disease Primers
- Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis
- (2018) Tamara H Ramwadhdoebe et al. RHEUMATOLOGY
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- Sample size requirements for learning to classify with high-dimensional biomarker panels
- (2017) Paul McKeigue STATISTICAL METHODS IN MEDICAL RESEARCH
- Effectiveness of Targeted Therapy in Patients With Previously Untreated Metastatic Breast Cancer: A Systematic Review and Meta-Analysis
- (2015) Paweł Kawalec et al. Clinical Breast Cancer
- Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer
- (2015) Hossein Borghaei et al. NEW ENGLAND JOURNAL OF MEDICINE
- High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease
- (2014) Serena Bugatti et al. RHEUMATOLOGY
- voom: precision weights unlock linear model analysis tools for RNA-seq read counts
- (2014) Charity W Law et al. GENOME BIOLOGY
- Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients
- (2013) S Kelly et al. ANNALS OF THE RHEUMATIC DISEASES
- Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
- (2013) Shuzhao Li et al. NATURE IMMUNOLOGY
- Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis
- (2012) John D Isaacs et al. ANNALS OF THE RHEUMATIC DISEASES
- Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab
- (2012) Vanessa E Hogan et al. ANNALS OF THE RHEUMATIC DISEASES
- Interferon type I signature may predict non response upon rituximab in rheumatoid arthritis patients
- (2012) Hennie G Raterman et al. ARTHRITIS RESEARCH & THERAPY
- Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8 + Type
- (2011) K. Crozat et al. JOURNAL OF IMMUNOLOGY
- Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients
- (2010) Rogier M. Thurlings et al. ARTHRITIS AND RHEUMATISM
- Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers
- (2009) Sarah A. Graham et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers
- (2009) B. BRESNIHAN et al. JOURNAL OF RHEUMATOLOGY
- The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation
- (2008) Bernard Vandooren et al. ARTHRITIS AND RHEUMATISM
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now