HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Genesis of the αβ T-cell receptor

(2019) Thomas Dupic et al.   PLoS Computational Biology

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

(2019) Jinghua Lu et al.   Nature Communications

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

(2019) Asbjørn Christophersen et al.   NATURE MEDICINE

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

(2019) Robert Busch et al.   Nature Reviews Rheumatology

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes

(2019) Tomasz Kula et al.   CELL

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

(2018) Yi Tian Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

(2018) William S DeWitt et al.   eLife

Citrullinated Aggrecan Epitopes as Targets of Auto-reactive CD4+ T cells in Patients with Rheumatoid Arthritis

(2018) Cliff Rims et al.   Arthritis & Rheumatology

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

(2017) Karen Cerosaletti et al.   JOURNAL OF IMMUNOLOGY

T Cells in Celiac Disease

(2017) Bana Jabri et al.   JOURNAL OF IMMUNOLOGY

Identifying specificity groups in the T cell receptor repertoire

(2017) Jacob Glanville et al.   NATURE

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

(2017) Asaf Madi et al.   eLife

Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

(2017) Nicole B. Crux et al.   Frontiers in Immunology

Contribution of a Non-classical HLA Gene, HLA-DOA , to the Risk of Rheumatoid Arthritis

(2016) Yukinori Okada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

(2016) A Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

(2016) Lu Chen et al.   CELL

TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage

(2016) S Dahal-Koirala et al.   Mucosal Immunology

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

(2016) Amalie Kai Bentzen et al.   NATURE BIOTECHNOLOGY

Genetic variation in MHC proteins is associated with T cell receptor expression biases

(2016) Eilon Sharon et al.   NATURE GENETICS

Hydrophobic CDR3 residues promote the development of self-reactive T cells

(2016) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

(2015) Xinli Hu et al.   NATURE GENETICS

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

(2015) Tobias L Lenz et al.   NATURE GENETICS

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

(2015) Javier Gutierrez-Achury et al.   NATURE GENETICS

Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens

(2015) Frits Koning et al.   Nature Reviews Rheumatology

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

(2014) Jan Petersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Dietary gluten triggers concomitant activation of CD4+ and CD8+    T cells and    T cells in celiac disease

(2013) A. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease

(2011) S.-W. Qiao et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS