Article
Optics
Fei-Chen Li, Yong-Bo Tang, Hao-Xue Qiao, Ting-Yun Shi
Summary: The relativistic coupled-cluster method was utilized to calculate various hyperfine-structure constants of low-lying states of Ra+, confirming the validity of the calculations. The study successfully extracted the electric quadrupole moments of Ra nuclei by combining theoretical and experimental data, and assessed the contribution of magnetic octupole hyperfine interaction to the hyperfine splitting. The sensitivity of hyperfine-structure interval measurements in Ra-223(+) was found to be on the order of kHz, revealing the effect of nuclear octupole moments.
JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS
(2021)
Article
Immunology
Christina Stehle, Timo Rueckert, Remi Fiancette, Dominika W. Gajdasik, Claire Willis, Carolin Ulbricht, Pawel Durek, Mir-Farzin Mashreghi, Daniela Finke, Anja Erika Hauser, David R. Withers, Hyun-Dong Chang, Jakob Zimmermann, Chiara Romagnani
Summary: The study reveals the unexpected roles of T-bet and ROR alpha during embryonic ILC function, with ROR gamma t being crucial in counteracting the suppressive effects of T-bet. Deficiency of T-bet rescues lymph node formation in ROR gamma t-deficient mice by skewing the differentiation fate of fetal ILCs.
Article
Biochemistry & Molecular Biology
Yuewen Luo, Xiantao Zhang, Ran Chen, Rong Li, Yang Liu, Junsong Zhang, Qin Liu, Meijun Si, Jun Liu, Bolin Wu, Xuemei Wang, Shijian Wu, Yiwen Zhang, Xu Zhang, Deyin Guo, Xin He, Ting Pan, Hui Zhang
Summary: This study found that the deubiquitinase USP10 can translocate into the nucleus and stabilize nuclear AID protein levels through AKT-mediated phosphorylation. Furthermore, the signals from BCR and TLR synergistically promote the phosphorylation of USP10. Deficiency of USP10 in B cells leads to decreased AID protein levels and reduced production of neutralizing antibodies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Roman Davydov, Austin E. Herzog, Richard J. Jodts, Kenneth D. Karlin, Brian M. Hoffman
Summary: In this study, the physical and chemical properties of monocopper Cu(I) superoxo and Cu(II) peroxo and hydroperoxo complexes were investigated. The complexes were prepared using cryoreduction/annealing technique and characterized using EPR and ENDOR spectroscopy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biology
Debora N. Frydryk N. Benitez, Monica A. Palmieri, Yanina V. V. Langle, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia I. I. Thorp, Marcela A. A. Garabalino, Paula Curotto, Paula S. S. Ramos, Maria L. Paparella, Lucas Polti, Ana Eijan, Amanda E. E. Schwint, Veronica A. Trivillin
Summary: Boron neutron capture therapy (BNCT) is a treatment method that utilizes the preferential uptake of B-10 compounds by tumors followed by neutron irradiation. This study aimed to evaluate the therapeutic efficacy, radiotoxicity, abscopal effect, and systemic immune response of Comb-BNCT alone or in combination with Oligo-Fucoidan (O-Fuco) or Glutamine (GLN) compared to the standard BPA-BNCT protocol. The results showed that Comb-BNCT had higher therapeutic values and reduced radiotoxicity compared to BPA-BNCT, and also induced an immune response and abscopal effect.
Article
Biochemistry & Molecular Biology
Felice Rivellese, Anna E. A. Surace, Katriona Goldmann, Elisabetta Sciacca, Cankut cubuk, Giovanni Giorli, Christopher R. John, Alessandra Nerviani, Liliane Fossati-Jimack, Georgina Thorborn, Manzoor Ahmed, Edoardo Prediletto, Sarah E. Church, Briana M. Hudson, Sarah E. Warren, Paul M. McKeigue, Frances Humby, Michele Bombardieri, Michael R. Barnes, Myles J. Lewis, Costantino Pitzalis
Summary: This study analyzes the biomarkers of the R4RA trial and identifies pretreatment synovial biopsy features that are selectively associated with the response to rituximab or tocilizumab in patients with rheumatoid arthritis. The study develops machine learning algorithms that can predict treatment response and highlights the importance of incorporating molecular pathology signatures into clinical algorithms for optimizing the use of existing medications and developing new drugs for refractory patients.
Article
Rheumatology
Susan M. Goodman, Bryan D. Springer, Antonia F. Chen, Marshall Davis, David R. Fernandez, Mark Figgie, Heather Finlayson, Michael D. George, Jon T. Giles, Jeremy Gilliland, Brian Klatt, Ronald MacKenzie, Kaleb Michaud, Andy Miller, Linda Russell, Alexander Sah, Matthew P. Abdel, Beverly Johnson, Lisa A. Mandl, Peter Sculco, Marat Turgunbaev, Amy S. Turner, Adolph Yates, Jasvinder A. Singh
Summary: This study developed updated guidelines for the perioperative management of disease-modifying medications for patients with rheumatic diseases undergoing elective total hip arthroplasty or elective total knee arthroplasty. The guidelines include recommendations for the use of traditional disease-modifying antirheumatic drugs, biologic agents, targeted synthetic small-molecule drugs, and glucocorticoids for the treatment of patients with inflammatory arthritis or systemic lupus erythematosus.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Anja Meyer, Ryan E. Sienes, Wes Nijim, Brian Zanotti, Sadiq Umar, Michael V. Volin, Katrien Van Raemdonck, Myles Lewis, Costantino Pitzalis, Shiva Arami, Mina Al-Awqati, Huan J. Chang, Pim Jetanalin, Georg Schett, Nadera Sweiss, Shiva Shahrara
Summary: The study found that syntenin-1 is enriched in rheumatoid arthritis (RA) specimens compared to osteoarthritis synovial fluid and normal synovial tissue. However, the cellular origin, immunoregulation and molecular mechanism of syntenin-1 in RA are still unknown.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Editorial Material
Rheumatology
Myles J. Lewis, Costantino Pitzalis
Summary: In 2022, significant progress was made in predicting treatment response in rheumatoid arthritis. This was achieved through gene-expression profiling in synovial biopsy samples, assessment of interferon-response genes in the blood, and the application of machine learning to patients' clinical parameters and genetic variance.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Immunology
Douglas Fritz, Jun Inamo, Fan Zhang
Summary: Recent advances in single-cell sequencing technologies have revealed the heterogeneity of fibroblasts and their potential clinical significance in inflammatory diseases. Computational techniques, including machine learning, have played a crucial role in categorizing fibroblast subpopulations and their interactions with other immune cells. These computational omics approaches have the potential to contribute to therapeutic strategies for inflammatory diseases by targeting fibroblast-macrophage interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Serene Z. Mirza, Yi Zhang, Huong T. Do, Bella Mehta, Susan M. Goodman, Anne R. Bass
Summary: Black patients have a higher risk of aseptic revision TKA compared to White patients, and this disparity is not related to surgeon characteristics.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Immunology
Melanie H. Smith, Vianne R. Gao, Preethi K. Periyakoil, Alejandro Kochen, Edward F. DiCarlo, Susan M. Goodman, Thomas M. Norman, Laura T. Donlin, Christina S. Leslie, Alexander Y. Rudensky
Summary: Smith et al. provide a detailed resource on the factors driving transcriptional heterogeneity of synovial fibroblasts during rheumatoid arthritis. The study explores the communication between immigrant and resident cell types in human inflammatory disease, highlighting the role of local exposure to cytokines in driving distinct fibroblast states. These findings enhance our understanding of the inflamed synovium and its contribution to disease progression.
Article
Rheumatology
Bella Mehta, Deanna Jannat-Khah, Katherine Kayla Glaser, Yiming Luo, Lisa R. Sammaritano, D. Ware Branch, Susan M. Goodman, Michael Lockshin, Fei Wang, Said Ibrahim, Jane E. Salmon
Summary: The study aimed to evaluate and quantify the indicators of fetal and maternal morbidity in deliveries for patients with systemic lupus erythematosus (SLE) compared with deliveries in patients without SLE. The findings showed that patients with SLE had a higher risk of fetal morbidity, including intrauterine growth restriction (IUGR) and preterm delivery, than patients without SLE. During delivery, mothers with SLE were at a higher risk of severe maternal morbidity, including blood transfusion, cerebrovascular disorders, and acute renal failure, compared to those without SLE. These results have important implications for guiding and counseling SLE patients during pregnancy and planning.
Article
Rheumatology
Nilasha Ghosh, Pankti Reid, Carlos Andres Aude, Jessica Kirschman, Susan Goodman, Vivian P. Bykerk, Amit Lakhanpal, Diviya Rajesh, Karmela K. Chan, William H. Robinson, Anne R. Bass
Summary: In this study, the expansion of ACPA epitopes in CCP+ICI-IA was compared with patients with RA. It was found that patients with ICI-IA had lower ACPA titres and targeted fewer ACPA epitopes compared to longstanding RA patients, and there were no significant differences in the presence of the shared epitope between ICI-IA patients and ICI controls. This suggests that ICI-IA may represent an accelerated model of RA pathogenesis.
Review
Biochemistry & Molecular Biology
Susan Siyu Wang, Myles J. Lewis, Costantino Pitzalis
Summary: Rheumatoid arthritis (RA) is a complex disease with heterogeneity in disease severity and treatment response. Current prediction methods for treatment response have limitations, and genetics and environmental factors alone cannot fully explain the differences between patients. Recent studies have shown that DNA methylation plays a role in the pathogenesis and progression of RA, and specific DNA methylation profiles in the blood may serve as predictive biomarkers. This review examines the evidence for DNA methylation signatures in treatment response and discusses the potential for future progress in this area.
Article
Medicine, Research & Experimental
Shyamala Thirunavukkarasu, Mushtaq Ahmed, Bruce A. Rosa, Mark Boothby, Sung Hoon Cho, Javier Rangel-Moreno, Stanley K. Mbandi, Valerie Schreiber, Ananya Gupta, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Thomas J. Scriba, Shabaana A. Khader
Summary: PARP9 mRNA is upregulated in TB patients and mice, and PARP9 plays a critical regulatory role in DNA damage, cGAS expression, and type I IFN production during TB. Parp9-deficient mice are susceptible to Mycobacterium tuberculosis infection with increased TB disease, cGAS and cGAMP expression, and type I IFN production, along with upregulation of complement and coagulation pathways. The increased TB susceptibility is type I IFN dependent, and blockade of IFNAR signaling reverses the enhanced susceptibility of Parp9-/- mice. In contrast to its enhancement of type I IFN production in viral infections, this member of the MAR family, PARP9, plays a protective role by limiting type I IFN responses during TB.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Rheumatology
Bella Mehta, Susan Goodman, Edward DiCarlo, Deanna Jannat-Khah, J. Alex B. Gibbons, Miguel Otero, Laura Donlin, Tania Pannellini, William H. H. Robinson, Peter Sculco, Mark Figgie, Jose Rodriguez, Jessica M. M. Kirschmann, James Thompson, David Slater, Damon Frezza, Zhenxing Xu, Fei Wang, Dana E. E. Orange
Summary: This study aimed to differentiate osteoarthritis (OA) and rheumatoid arthritis (RA) by examining hematoxylin and eosin (H&E)-stained synovial tissue samples. OA patients exhibited increased mast cells and fibrosis, while RA patients showed increased lymphocytic inflammation, lining hyperplasia, neutrophils, detritus, plasma cells, binucleate plasma cells, sub-lining giant cells, fibrin, Russell bodies, and synovial lining giant cells. Combining pathologist scores with cell density metrics improved the classification accuracy.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Cell Biology
Hirotaka Iijima, Fan Zhang, Fabrisia Ambrosio, Yusuke Matsui
Summary: This study demonstrates the role of inflammatory cytokines in cartilage degradation and the impact of aging on this process. It identifies Oncostatin M as a driver of aberrant matrix remodeling and highlights high-value targets for drug development and repurposing in treating knee osteoarthritis.
Article
Rheumatology
Katriona Goldmann, Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Nisha Nair, Cankut Cubuk, Paul McKeigue, Michael R. Barnes, Anne Barton, Costantino Pitzalis, Myles J. Lewis
Summary: This study conducted expression quantitative trait locus (eQTL) analysis using RNA-Sequencing to explore the link between genetic variants and gene expression in rheumatoid arthritis (RA) patients. The analysis identified 898 eQTL genes in synovium and blood, with 232 genes in common. A specific eQTL at HLA-DPB2 was found to be associated with clinical severity and the lympho-myeloid pathotype.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
