Activity-Dependent Synapse Refinement: From Mechanisms to Molecules

The molecular signals that regulate activity-dependent synapse refinement in the brain

(2023) Sivapratha Nagappan-Chettiar et al.   CURRENT OPINION IN NEUROBIOLOGY

Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

(2022) Danyang He et al.   IMMUNITY

The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice

(2022) Alena Maul et al.   eLife

Brain charts for the human lifespan

(2022) R. A. I. Bethlehem et al.   NATURE

Modular strategy for development of the hierarchical visual network in mice

(2022) Tomonari Murakami et al.   NATURE

Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice

(2022) Yohan S. S. Auguste et al.   NATURE NEUROSCIENCE

Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus

(2022) Teresa Guillamón-Vivancos et al.   SCIENCE

Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice

(2022) Rafael T. Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oligodendrocyte precursor cells ingest axons in the mouse neocortex

(2022) JoAnn Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental spontaneous activity promotes formation of sensory domains, frequency tuning and proper gain in central auditory circuits

(2022) Calvin J. Kersbergen et al.   Cell Reports

Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses

(2021) Jungjoo Park et al.   EMBO JOURNAL

An activity-dependent determinant of synapse elimination in the mammalian brain

(2021) Masahiro Yasuda et al.   NEURON

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

(2021) Xin Ding et al.   Nature Communications

GABA-receptive microglia selectively sculpt developing inhibitory circuits

(2021) Emilia Favuzzi et al.   CELL

C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex

(2021) Qifei Cong et al.   GLIA

Stress impacts sensory variability through cortical sensory activity motifs

(2020) Alexander McGirr et al.   Translational Psychiatry

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

(2020) Tao Li et al.   EMBO JOURNAL

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

(2020) John Kealy et al.   JOURNAL OF NEUROSCIENCE

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

(2020) Qifei Cong et al.   NATURE NEUROSCIENCE

Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism

(2020) Lucas Cheadle et al.   NEURON

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

Prenatal activity from thalamic neurons governs the emergence of functional cortical maps in mice

(2019) Noelia Antón-Bolaños et al.   SCIENCE

Structured spike series specify gene expression patterns for olfactory circuit formation

(2019) Ai Nakashima et al.   SCIENCE

Visual Cortex Gains Independence from Peripheral Drive before Eye Opening

(2019) Alexandra Gribizis et al.   NEURON

Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q

(2019) Christina A. Welsh et al.   JOURNAL OF NEUROSCIENCE

Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement

(2018) Lucas Cheadle et al.   NEURON

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

(2018) Giovanni Di Liberto et al.   CELL

Homeostatic Control of Spontaneous Activity in the Developing Auditory System

(2018) Travis A. Babola et al.   NEURON

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Seeing faces is necessary for face-domain formation

(2017) Michael J Arcaro et al.   NATURE NEUROSCIENCE

Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function

(2017) Sivapratha Nagappan-Chettiar et al.   NEUROSCIENCE RESEARCH

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands

(2017) Greg Lemke   TRENDS IN BIOCHEMICAL SCIENCES

Prenatal thalamic waves regulate cortical area size prior to sensory processing

(2017) Verónica Moreno-Juan et al.   Nature Communications

Development of Activity in the Mouse Visual Cortex

(2016) J. Shen et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Cortical Feedback Regulates Feedforward Retinogeniculate Refinement

(2016) Andrew D. Thompson et al.   NEURON

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Spatiotemporal Features of Retinal Waves Instruct the Wiring of the Visual Circuitry

(2016) David A. Arroyo et al.   Frontiers in Neural Circuits

An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus

(2016) Yasunobu Murata et al.   eLife

Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency

(2015) Hong-Ping Xu et al.   Developmental Neurobiology

Retrograde Plasticity and Differential Competition of Bipolar Cell Dendrites and Axons in the Developing Retina

(2014) Robert E. Johnson et al.   CURRENT BIOLOGY

Emergence of Feature-Specific Connectivity in Cortical Microcircuits in the Absence of Visual Experience

(2014) H. Ko et al.   JOURNAL OF NEUROSCIENCE

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

The Precise Temporal Pattern of Prehearing Spontaneous Activity Is Necessary for Tonotopic Map Refinement

(2014) Amanda Clause et al.   NEURON

Refinement of the Retinogeniculate Synapse by Bouton Clustering

(2014) Y. Kate Hong et al.   NEURON

Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors

(2014) Timothy J. Burbridge et al.   NEURON

Interplay of Cell-Autonomous and Nonautonomous Mechanisms Tailors Synaptic Connectivity of Converging Axons In Vivo

(2014) Haruhisa Okawa et al.   NEURON

A Role for Stargazin in Experience-Dependent Plasticity

(2014) Susana R. Louros et al.   Cell Reports

The emergence of functional microcircuits in visual cortex

(2013) Ho Ko et al.   NATURE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

(2013) Lowry A. Kirkby et al.   NEURON

Spontaneous Network Activity and Synaptic Development

(2013) Daniel Kerschensteiner   NEUROSCIENTIST

PirB regulates a structural substrate for cortical plasticity

(2013) M. Djurisic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral and Central Inputs Shape Network Dynamics in the Developing Visual Cortex In Vivo

(2012) Friederike Siegel et al.   CURRENT BIOLOGY

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

Retinal waves coordinate patterned activity throughout the developing visual system

(2012) James B. Ackman et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

How do barrels form in somatosensory cortex?

(2011) Hong Li et al.   Annals of the New York Academy of Sciences

Visual map development depends on the temporal pattern of binocular activity in mice

(2011) Jiayi Zhang et al.   NATURE NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Experience-Dependent Retinogeniculate Synapse Remodeling Is Abnormal in MeCP2-Deficient Mice

(2011) Joao Noutel et al.   NEURON

An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development

(2011) Hong-ping Xu et al.   NEURON

Multiple Forms of Activity-Dependent Competition Refine Hippocampal Circuits In Vivo

(2011) Masahiro Yasuda et al.   NEURON

Visual Receptive Field Properties of Neurons in the Superficial Superior Colliculus of the Mouse

(2010) L. Wang et al.   JOURNAL OF NEUROSCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Mechanisms underlying spontaneous patterned activity in developing neural circuits

(2009) Aaron G. Blankenship et al.   NATURE REVIEWS NEUROSCIENCE

Sparsification of neuronal activity in the visual cortex at eye-opening

(2009) N. L. Rochefort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Development of Visual Maps and Receptive Fields

(2008) Andrew D. Huberman et al.   Annual Review of Neuroscience

Vision Triggers an Experience-Dependent Sensitive Period at the Retinogeniculate Synapse

(2008) B. M. Hooks et al.   JOURNAL OF NEUROSCIENCE

Experience with moving visual stimuli drives the early development of cortical direction selectivity

(2008) Ye Li et al.   NATURE