Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery

Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles

(2022) Marine Z. C. Hatit et al.   Nature Nanotechnology

Drug delivery systems for RNA therapeutics

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Extracellular vesicles as a next-generation drug delivery platform

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CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

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Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

(2020) Miquel Duran-Frigola et al.   NATURE BIOTECHNOLOGY

Polymeric vehicles for nucleic acid delivery

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Clathrin mediated endocytosis is involved in the uptake of exogenous double-stranded RNA in the white mold phytopathogen Sclerotinia sclerotiorum

(2020) Nick Wytinck et al.   Scientific Reports

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

(2020) Zubao Gan et al.   Bioengineering & Translational Medicine

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

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Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

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Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

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Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

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High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

(2019) Song Chen et al.   NATURE BIOTECHNOLOGY

Interleukin-36γ–producing macrophages drive IL-17–mediated fibrosis

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A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

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Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

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Single cell RNA sequencing of stem cell-derived retinal ganglion cells

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Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo

(2018) Cory D. Sago et al.   NANO LETTERS

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

(2018) Pooja Munnilal Tiwari et al.   Nature Communications

Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution

(2018) Cory D. Sago et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

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Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

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Massively parallel digital transcriptional profiling of single cells

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KEGG: new perspectives on genomes, pathways, diseases and drugs

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RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells

(2016) Teresa Garcia-Aguilar et al.   Journal of Immunology Research

Thalidomide-induced teratogenesis: History and mechanisms

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Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

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Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

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In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

(2013) Daniel Nedelcu et al.   Nature Chemical Biology

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

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Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

The Significance of Chirality in Drug Design and Development

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LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV

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Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

(2011) Christina Lorenz et al.   RNA Biology

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

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Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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