Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
Authors
Keywords
-
Journal
NATURE BIOTECHNOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-05-19
DOI
10.1038/s41587-020-0502-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- De novo generation of hit-like molecules from gene expression signatures using artificial intelligence
- (2020) Oscar Méndez-Lucio et al. Nature Communications
- A Computational Framework for Genome-wide Characterization of the Human Disease Landscape
- (2019) Young-suk Lee et al. Cell Systems
- Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling
- (2018) Wen-Jian Hu et al. BIOMEDICINE & PHARMACOTHERAPY
- Glimmers in illuminating the druggable genome
- (2018) Griffin Rodgers et al. NATURE REVIEWS DRUG DISCOVERY
- Deep learning improves prediction of drug–drug and drug–food interactions
- (2018) Jae Yong Ryu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MoleculeNet: a benchmark for molecular machine learning
- (2018) Zhenqin Wu et al. Chemical Science
- Non-invasive delivery strategies for biologics
- (2018) Aaron C. Anselmo et al. NATURE REVIEWS DRUG DISCOVERY
- Open Targets Platform: new developments and updates two years on
- (2018) Denise Carvalho-Silva et al. NUCLEIC ACIDS RESEARCH
- Predicted Biological Activity of Purchasable Chemical Space
- (2017) John J. Irwin et al. Journal of Chemical Information and Modeling
- A Simple Representation of Three-Dimensional Molecular Structure
- (2017) Seth D. Axen et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Drug Repurposing Hub: a next-generation drug library and information resource
- (2017) Steven M Corsello et al. NATURE MEDICINE
- The Reactome Pathway Knowledgebase
- (2017) Antonio Fabregat et al. NUCLEIC ACIDS RESEARCH
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Classification and analysis of a large collection of in vivo bioassay descriptions
- (2017) Magdalena Zwierzyna et al. PLoS Computational Biology
- Representing high throughput expression profiles via perturbation barcodes reveals compound targets
- (2017) Tracey M. Filzen et al. PLoS Computational Biology
- A standard database for drug repositioning
- (2017) Adam S. Brown et al. Scientific Data
- A Landscape of Pharmacogenomic Interactions in Cancer
- (2016) Francesco Iorio et al. CELL
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- NCI-60 Cell Line Screening: A Radical Departure in its Time
- (2016) Bruce A. Chabner JNCI-Journal of the National Cancer Institute
- Counting on natural products for drug design
- (2016) Tiago Rodrigues et al. Nature Chemistry
- A scored human protein–protein interaction network to catalyze genomic interpretation
- (2016) Taibo Li et al. NATURE METHODS
- Pharos: Collating protein information to shed light on the druggable genome
- (2016) Dac-Trung Nguyen et al. NUCLEIC ACIDS RESEARCH
- The ChEMBL database in 2017
- (2016) Anna Gaulton et al. NUCLEIC ACIDS RESEARCH
- DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
- (2016) Janet Piñero et al. NUCLEIC ACIDS RESEARCH
- PubChem BioAssay: 2017 update
- (2016) Yanli Wang et al. NUCLEIC ACIDS RESEARCH
- PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements
- (2016) Huaiyu Mi et al. NUCLEIC ACIDS RESEARCH
- The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
- (2016) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- The Comparative Toxicogenomics Database: update 2017
- (2016) Allan Peter Davis et al. NUCLEIC ACIDS RESEARCH
- The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins
- (2016) Andrew D. Rouillard et al. Database-The Journal of Biological Databases and Curation
- NCI-60 Cell Line Screening: A Radical Departure in its Time
- (2016) Bruce A. Chabner JNCI-Journal of the National Cancer Institute
- The Chemical Space Project
- (2015) Jean-Louis Reymond ACCOUNTS OF CHEMICAL RESEARCH
- ZINC 15 – Ligand Discovery for Everyone
- (2015) Teague Sterling et al. Journal of Chemical Information and Modeling
- Activity, assay and target data curation and quality in the ChEMBL database
- (2015) George Papadatos et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- ChEBI in 2016: Improved services and an expanding collection of metabolites
- (2015) Janna Hastings et al. NUCLEIC ACIDS RESEARCH
- KEGG as a reference resource for gene and protein annotation
- (2015) Minoru Kanehisa et al. NUCLEIC ACIDS RESEARCH
- BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology
- (2015) Michael K. Gilson et al. NUCLEIC ACIDS RESEARCH
- The SIDER database of drugs and side effects
- (2015) Michael Kuhn et al. NUCLEIC ACIDS RESEARCH
- Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
- (2015) B. Seashore-Ludlow et al. Cancer Discovery
- Large-Scale Chemical Similarity Networks for Target Profiling of Compounds Identified in Cell-Based Chemical Screens
- (2015) Yu-Chen Lo et al. PLoS Computational Biology
- MEK and PI3K inhibition in solid tumors: rationale and evidence to date
- (2015) E. Jokinen et al. Therapeutic Advances in Medical Oncology
- Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
- (2014) Mark D M Leiserson et al. NATURE GENETICS
- Similarity network fusion for aggregating data types on a genomic scale
- (2014) Bo Wang et al. NATURE METHODS
- Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
- (2014) M. J. Wawer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A chemo-centric view of human health and disease
- (2014) Miquel Duran-Frigola et al. Nature Communications
- ECOD: An Evolutionary Classification of Protein Domains
- (2014) Hua Cheng et al. PLoS Computational Biology
- An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
- (2013) Amrita Basu et al. CELL
- Analysis of Chemical and Biological Features Yields Mechanistic Insights into Drug Side Effects
- (2013) Miquel Duran-Frigola et al. CHEMISTRY & BIOLOGY
- Systematic identification of proteins that elicit drug side effects
- (2013) M. Kuhn et al. Molecular Systems Biology
- A community-driven global reconstruction of human metabolism
- (2013) Ines Thiele et al. NATURE BIOTECHNOLOGY
- The Genetics of Alzheimer Disease
- (2013) R. E. Tanzi Cold Spring Harbor Perspectives in Medicine
- Rethinking Molecular Similarity: Comparing Compounds on the Basis of Biological Activity
- (2012) Paula M. Petrone et al. ACS Chemical Biology
- Open PHACTS: semantic interoperability for drug discovery
- (2012) Antony J. Williams et al. DRUG DISCOVERY TODAY
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- Interactome3D: adding structural details to protein networks
- (2012) Roberto Mosca et al. NATURE METHODS
- Global Analysis of Small Molecule Binding to Related Protein Targets
- (2012) Felix A. Kruger et al. PLoS Computational Biology
- Chapter 3: Small Molecules and Disease
- (2012) David S. Wishart PLoS Computational Biology
- Multiple imputation by chained equations: what is it and how does it work?
- (2011) Melissa J. Azur et al. INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
- Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab
- (2011) Jacqueline M Benson et al. NATURE BIOTECHNOLOGY
- WikiPathways: building research communities on biological pathways
- (2011) T. Kelder et al. NUCLEIC ACIDS RESEARCH
- A similarity measure for indefinite rankings
- (2010) William Webber et al. ACM TRANSACTIONS ON INFORMATION SYSTEMS
- Privileged scaffolds for library design and drug discovery
- (2010) Matthew E Welsch et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Apigenin induces apoptosis and impairs head and neck carcinomas EGFR/ErbB2 signaling
- (2010) Laura Masuelli Frontiers in Bioscience-Landmark
- Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines
- (2010) S. L. Holbeck et al. MOLECULAR CANCER THERAPEUTICS
- MetaPhOrs: orthology and paralogy predictions from multiple phylogenetic evidence using a consistency-based confidence score
- (2010) Leszek P. Pryszcz et al. NUCLEIC ACIDS RESEARCH
- Pathway Commons, a web resource for biological pathway data
- (2010) E. G. Cerami et al. NUCLEIC ACIDS RESEARCH
- Discovery of drug mode of action and drug repositioning from transcriptional responses
- (2010) F. Iorio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NetPath: a public resource of curated signal transduction pathways
- (2010) Kumaran Kandasamy et al. GENOME BIOLOGY
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel
- (2008) A. Sawai et al. CANCER RESEARCH
- Drug Target Identification Using Side-Effect Similarity
- (2008) M. Campillos et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started