A Brief Review on the Synthesis of the N-CF3 Motif in Heterocycles

General Synthesis of N-Trifluoromethyl Compounds with N-Trifluoromethyl Hydroxylamine Reagents

(2022) Shuai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N‐CF3 Imidazolidin‐2‐one Derivatives via Photocatalytic and Silver‐Catalyzed Cyclizations

(2022) Abdurrahman Turksoy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Access to Cyclic N-Trifluoromethyl Ureas through Photocatalytic Activation of Carbamoyl Azides

(2022) Samir Bouayad-Gervais et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of N-CF3 Amidines/Imidates/Thioimidates via N-CF3 Nitrilium Ions

(2022) Ru Zhong Zhang et al.   ORGANIC LETTERS

A Facile and Inexpensive Way to Synthesize N‐trifluoromethyl Compounds

(2022) Stefan Schaub et al.   ChemistrySelect

Photoredox/copper‐Catalyzed Trifluoromethylamino‐cyanation of 1,3‐Enynes

(2022) Shuai Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

N ‐Fluoroalkylated Morpholinos – a New Class of Nucleoside Analogues

(2022) Nóra Debreczeni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of N-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of N-fluoroalkyl-1,2,3-triazoles with terminal alkynes

(2021) Olga Bakhanovich et al.   Beilstein Journal of Organic Chemistry

Synthesis of N-CF3 Alkynamides and Derivatives Enabled by Ni-Catalyzed Alkynylation of N-CF3 Carbamoyl Fluorides

(2021) Christian D.-T. Nielsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N ‐Trifluoromethyl Hydrazines, Indoles and Their Derivatives

(2020) Samir Bouayad‐Gervais et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)‐η3‐allyl complexes bearing N‐trifluoromethyl N‐heterocyclic carbenes:a new generation of anticancer agents which restrain the growth of high grade serous ovarian cancer tumoroids

(2020) Fabiano Visentin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

(2020) Dimitris Matiadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Direct Synthesis of Thiocarbamoyl Fluorides and Trifluoromethylamines Through Fluorinative Desulfurization

(2019) Killian Onida et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Straightforward access to N-trifluoromethyl amides, carbamates, thiocarbamates and ureas

(2019) Thomas Scattolin et al.   NATURE

A rhodium-catalyzed transannulation of N-(per)fluoroalkyl-1,2,3-triazoles under microwave conditions – a general route to N-(per)fluoroalkyl-substituted five-membered heterocycles

(2018) Vladimir Motornov et al.   CHEMICAL COMMUNICATIONS

The main and recent syntheses of the N -CF 3 motif

(2018) Thierry Milcent et al.   COMPTES RENDUS CHIMIE

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Enamine-Mediated Azide-Ketone [3 + 2] Cycloaddition of Azidoperfluoroalkanes

(2018) Zsófia E. Blastik et al.   ChemistrySelect

Chemoselective Aza-[4+3]-annulation of N-Perfluoroalkyl-1,2,3-triazoles with 1,3-Dienes: Access to N-Perfluoroalkyl-Substituted Azepines

(2018) Vladimir Motornov et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

(2017) Pounami Samadder et al.   MOLECULAR CANCER THERAPEUTICS

Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2016) Zsófia E. Blastik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Synthesis of Trifluoromethyl Amines through a Formal Umpolung Strategy from the Bench-Stable Precursor (Me4 N)SCF3

(2016) Thomas Scattolin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Copper(I)-Catalyzed Three-Component Coupling ofN-Tosylhydrazones, Alkynes and Azides: Synthesis of Trisubstituted 1,2,3-Triazoles

(2015) Zhikun Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding

(2014) Gilles H. Goetz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides

(2014) Gilles H. Goetz et al.   ACS Medicinal Chemistry Letters

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Electrophilic N-Trifluoromethylation of Azoles by a Hypervalent Iodine Reagent

(2012) Katrin Niedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO

(2012) Bin Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

A Ritter-Type Reaction: Direct Electrophilic Trifluoromethylation at Nitrogen Atoms Using Hypervalent Iodine Reagents

(2010) Katrin Niedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-trifluoromethylazoles

(2009) T. M. Sokolenko et al.   Chemistry of Heterocyclic Compounds

Toward the Synthesis of the RareN-(Trifluoromethyl)amides and theN-(Difluoromethylene)-N-(trifluoromethyl)amines [RN(CF3)CF2R′] Using BrF3

(2009) Youlia Hagooly et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS