RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation
Authors
Keywords
-
Journal
MOLECULAR CELL
Volume 83, Issue 7, Pages 1061-1074.e6
Publisher
Elsevier BV
Online
2023-03-02
DOI
10.1016/j.molcel.2023.02.008
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- DNA-PKcs promotes fork reversal and chemoresistance
- (2022) Diego Dibitetto et al. MOLECULAR CELL
- The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
- (2022) Ashna Dhoonmoon et al. Nature Communications
- Best practices for the visualization, mapping, and manipulation of R‐loops
- (2021) Frédéric Chédin et al. EMBO JOURNAL
- RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination
- (2021) Sijie Liu et al. CELL
- BRCA2 promotes R‐loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination
- (2021) Gaetana Sessa et al. EMBO JOURNAL
- Replication dynamics of recombination-dependent replication forks
- (2021) Karel Naiman et al. Nature Communications
- Monitoring Schizosaccharomyces pombe genome stress by visualizing end-binding protein Ku
- (2021) Chance E. Jones et al. Biology Open
- R-loops as Janus-faced modulators of DNA repair
- (2021) Aline Marnef et al. NATURE CELL BIOLOGY
- Non-homologous end-joining at challenged replication forks: an RNA connection?
- (2021) Charlotte Audoynaud et al. TRENDS IN GENETICS
- Harmful R-loops are prevented via different cell cycle-specific mechanisms
- (2021) Marta San Martin-Alonso et al. Nature Communications
- Toxic R-loops: Cause or consequence of replication stress?
- (2021) Samira Kemiha et al. DNA REPAIR
- RNA at DNA Double‐Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids
- (2020) Judit Domingo‐Prim et al. BIOESSAYS
- One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA
- (2020) Giulia Maria Nava et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity
- (2020) Chetan C. Rawal et al. Cell Reports
- The MRE11 complex: A versatile toolkit for the repair of broken DNA
- (2020) Giordano Reginato et al. DNA REPAIR
- RNA: a double-edged sword in genome maintenance
- (2020) Dali Zong et al. NATURE REVIEWS GENETICS
- The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
- (2020) Matteo Berti et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
- (2020) James M. Daley et al. Nature Communications
- Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
- (2020) Alexy Promonet et al. Nature Communications
- XRN2 Links RNA:DNA Hybrid Resolution to Double Strand Break Repair Pathway Choice
- (2020) Tuyen T. Dang et al. Cancers
- RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis
- (2020) Susana M. Cerritelli et al. CURRENT GENETICS
- ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
- (2020) Sébastien Britton et al. NUCLEIC ACIDS RESEARCH
- ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
- (2019) Gabriel Balmus et al. Nature Communications
- Factors affecting template switch recombination associated with restarted DNA replication
- (2019) Manisha Jalan et al. eLife
- RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools
- (2019) Alice Meroni et al. NUCLEIC ACIDS RESEARCH
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- XLF and H2AX function in series to promote replication fork stability
- (2019) Bo-Ruei Chen et al. JOURNAL OF CELL BIOLOGY
- Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
- (2019) Javier Garzón et al. Cell Reports
- RIF1 promotes replication fork protection and efficient restart to maintain genome stability
- (2019) Chirantani Mukherjee et al. Nature Communications
- Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
- (2019) Fabio Pessina et al. NATURE CELL BIOLOGY
- R Loops: From Physiological to Pathological Roles
- (2019) Tatiana García-Muse et al. CELL
- MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading
- (2019) Axel Delamarre et al. MOLECULAR CELL
- MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
- (2019) Emily Yun-Chia Chang et al. Nature Communications
- RNase H eliminates R‐loops that disrupt DNA replication but is nonessential for efficient DSB repair
- (2018) Hongchang Zhao et al. EMBO REPORTS
- Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning
- (2018) Luca Menin et al. EMBO REPORTS
- Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
- (2018) Sarah Cohen et al. Nature Communications
- Preserving replication fork integrity and competence via the homologous recombination pathway
- (2018) Anissia Ait Saada et al. DNA REPAIR
- A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection
- (2018) Weibin Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability
- (2018) Lorenzo Costantino et al. MOLECULAR CELL
- SAMHD1 acts at stalled replication forks to prevent interferon induction
- (2018) Flavie Coquel et al. NATURE
- XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining
- (2018) Clement Nemoz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- R‐loop formation during S phase is restricted by PrimPol‐mediated repriming
- (2018) Saša Šviković et al. EMBO JOURNAL
- BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
- (2018) Giuseppina D’Alessandro et al. Nature Communications
- Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection
- (2017) Giordano Reginato et al. GENES & DEVELOPMENT
- Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges
- (2017) Anissia Ait Saada et al. MOLECULAR CELL
- Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
- (2017) Flavia Michelini et al. NATURE CELL BIOLOGY
- The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks
- (2017) Ana Teixeira-Silva et al. Nature Communications
- MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
- (2017) Delphine Lemaçon et al. Nature Communications
- Replication fork reversal triggers fork degradation in BRCA2-defective cells
- (2017) Sofija Mijic et al. Nature Communications
- Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair
- (2016) Corina Ohle et al. CELL
- DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks
- (2016) Lei Li et al. MOLECULAR AND CELLULAR BIOLOGY
- Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
- (2016) Anirban Chakraborty et al. Nature Communications
- Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
- (2016) Pauline Chanut et al. Nature Communications
- Replication fork reversal in eukaryotes: from dead end to dynamic response
- (2015) Kai J. Neelsen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse
- (2015) Michael O Nguyen et al. eLife
- Ku Stabilizes Replication Forks in the Absence of Brc1
- (2015) Arancha Sánchez et al. PLoS One
- Replication forks reverse at high frequency upon replication stress in Physarum polycephalum
- (2014) Chrystelle Maric et al. CHROMOSOMA
- Reduction of hRNase H2 activity in Aicardi–Goutières syndrome cells leads to replication stress and genome instability
- (2014) Sara Pizzi et al. HUMAN MOLECULAR GENETICS
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- RNase H2 roles in genome integrity revealed by unlinking its activities
- (2013) Hyongi Chon et al. NUCLEIC ACIDS RESEARCH
- Okazaki Fragment Metabolism
- (2013) L. Balakrishnan et al. Cold Spring Harbor Perspectives in Biology
- The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing
- (2012) Jiazhi Hu et al. CELL
- RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA
- (2012) Federico Lazzaro et al. MOLECULAR CELL
- Recombination-restarted replication makes inverted chromosome fusions at inverted repeats
- (2012) Ken’Ichi Mizuno et al. NATURE
- Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone
- (2012) Ismail Iraqui et al. PLoS Genetics
- Cell-Cycle Analysis of Fission Yeast Cells by Flow Cytometry
- (2011) Jon Halvor Jonsrud Knutsen et al. PLoS One
- Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
- (2011) Petra Langerak et al. PLoS Genetics
- Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange
- (2010) Sarah Lambert et al. MOLECULAR CELL
- Fission yeast Ku protein is required for recovery from DNA replication stress
- (2009) Tomoichiro Miyoshi et al. GENES TO CELLS
- Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII
- (2008) Muhammad S. Rohman et al. FEBS Journal
- Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint
- (2007) Benoît Froget et al. MOLECULAR BIOLOGY OF THE CELL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now