RIF1 promotes replication fork protection and efficient restart to maintain genome stability

53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress

(2018) Joonyoung Her et al.   MOLECULAR AND CELLULAR BIOLOGY

RADX Modulates RAD51 Activity to Control Replication Fork Protection

(2018) Kamakoti P. Bhat et al.   Cell Reports

SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice

(2018) Steven Findlay et al.   EMBO JOURNAL

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability

(2017) Shengfeng Xu et al.   GENES & DEVELOPMENT

PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors

(2017) Meng S. Choy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

(2017) Huzefa Dungrawala et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

(2017) Beatrice Rondinelli et al.   NATURE CELL BIOLOGY

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

(2017) Shin-Ya Isobe et al.   Cell Reports

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

(2017) Robert C. Alver et al.   Cell Reports

53BP1 and BRCA1 control pathway choice for stalled replication restart

(2017) Yixi Xu et al.   eLife

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

(2017) S Kumar et al.   Oncogenesis

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)

(2017) Rasa Sukackaite et al.   Scientific Reports

Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program

(2016) Rossana Foti et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

(2016) Akshay K. Ahuja et al.   Nature Communications

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

(2016) Xia Ding et al.   Nature Communications

Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability

(2015) Rutger C.C. Hengeveld et al.   DEVELOPMENTAL CELL

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

(2015) Martin R. Higgs et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Biophysical Characterization of Murine Rif1 C Terminus Reveals High Specificity for DNA Cruciform Structures

(2014) Rasa Sukackaite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells

(2012) Josep V. Forment et al.   CYTOMETRY PART A

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

(2010) Dongyi Xu et al.   EMBO JOURNAL

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

(2009) Sara B.C. Buonomo et al.   JOURNAL OF CELL BIOLOGY

A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics

(2009) Jürgen Cox et al.   Nature Protocols