Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer

Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma

(2022) Wei Liu et al.   Cancer Biology & Medicine

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

Non-Canonical Programmed Cell Death in Colon Cancer

(2022) Bingchen Pan et al.   Cancers

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma

(2021) Zhen-Yuan Zheng et al.   Cancers

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

(2021) Xun Shangguan et al.   Nature Communications

Mitochondrial regulation of ferroptosis

(2021) Boyi Gan   JOURNAL OF CELL BIOLOGY

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

(2021) Wei Liu et al.   Nature Communications

Advances in the curative management of oesophageal cancer

(2021) Jarlath C. Bolger et al.   BRITISH JOURNAL OF CANCER

iProX in 2021: connecting proteomics data sharing with big data

(2021) Tao Chen et al.   NUCLEIC ACIDS RESEARCH

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

(2020) Ufuk Degirmenci et al.   Cells

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial

(2020) Shuhong Wang et al.   CLINICAL CANCER RESEARCH

STAT3, the Challenge for Chemotherapeutic and Radiotherapeutic Efficacy

(2020) Ping-Lian Yang et al.   Cancers

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

(2019) Xuejiao Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Drug repurposing: a promising tool to accelerate the drug discovery process

(2019) Vineela Parvathaneni et al.   DRUG DISCOVERY TODAY

RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes

(2019) Rui‐Jie Zeng et al.   Molecular Oncology

Statin use and its potential therapeutic role in esophageal cancer: a systematic review and meta-analysis

(2019) Cen Zhou et al.   Cancer Management and Research

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Drug repurposing for breast cancer therapy: Old weapon for new battle

(2019) Sadhna Aggarwal et al.   SEMINARS IN CANCER BIOLOGY

Disruption of the NF-κB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation

(2019) Hack Sun Choi et al.   Cells

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Role of modern immunotherapy in gastrointestinal malignancies: a review of current clinical progress

(2017) Zin W. Myint et al.   Journal of Hematology & Oncology

Oesophageal cancer

(2017) Jesper Lagergren et al.   LANCET

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Oesophageal cancer

(2017) Elizabeth C. Smyth et al.   Nature Reviews Disease Primers

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

(2017) Scott Thomson et al.   Scientific Reports

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

(2016) Steffanie L. Furtek et al.   ACS Chemical Biology

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

(2016) Tatiana Y. Hargrove et al.   JOURNAL OF LIPID RESEARCH

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

(2016) Paweł Lis et al.   MOLECULES

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

STAT3 in Cancer—Friend or Foe?

(2014) Hai-Feng Zhang et al.   Cancers

Hexokinase 1 blocks apoptotic signals at the mitochondria

(2013) Anja Schindler et al.   CELLULAR SIGNALLING

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Profiling the expression of cytochrome P450 in breast cancer

(2010) Graeme I Murray et al.   HISTOPATHOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE