STAT3β Enhances Sensitivity to Concurrent Chemoradiotherapy by Inducing Cellular Necroptosis in Esophageal Squamous Cell Carcinoma

Autocrine IL6-Mediated Activation of the STAT3–DNMT Axis Silences the TNFα–RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells

(2020) Alyssa D. Smith et al.   CANCER RESEARCH

STAT3beta, a distinct isoform from STAT3

(2019) Hui-Xiang Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

STAT3 Contributes To Oncolytic Newcastle Disease Virus-Induced Immunogenic Cell Death in Melanoma Cells

(2019) Xiaoyan Shao et al.   Frontiers in Oncology

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Ischemia Reperfusion Induces Death Receptor-Independent Necroptosis via Calpain-STAT3 Activation in a Lung Transplant Setting

(2018) Hyunhee Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma

(2018) Yulin Sun et al.   CANCER LETTERS

STAT3 isoforms: Alternative fates in cancer?

(2018) Petra Aigner et al.   CYTOKINE

STAT3: a multifaceted oncoprotein

(2018) Aleks C. Guanizo et al.   GROWTH FACTORS

Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3- and NF‑κB-mediated IL‑24 production

(2018) Jeong-Yub Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The crucial role of blood VEGF kinetics in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

(2018) Yen-Hao Chen et al.   BMC CANCER

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Constitutive activated STAT3 is an essential regulator and therapeutic target in esophageal squamous cell carcinoma

(2017) Fang Tian et al.   Oncotarget

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

(2016) Kevin D. McCormick et al.   CARCINOGENESIS

Involved-field irradiation in definitive chemoradiotherapy for T4 squamous cell carcinoma of the esophagus

(2016) M. Li et al.   Current Oncology

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3  in Esophageal Squamous Cell Carcinoma

(2015) H.-F. Zhang et al.   CLINICAL CANCER RESEARCH

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

(2015) Xiaoyun Dai et al.   Molecular Oncology

Expression of activated signal transducer and activator of transcription-3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma

(2015) Chuying Huang et al.   World Journal of Surgical Oncology

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A three-gene signature and clinical outcome in esophageal squamous cell carcinoma

(2014) Ling-Ling Sun et al.   INTERNATIONAL JOURNAL OF CANCER

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

(2014) A-L Nugues et al.   Cell Death & Disease

STAT3 in Cancer—Friend or Foe?

(2014) Hai-Feng Zhang et al.   Cancers

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

(2014) Uddalak Bharadwaj et al.   Cancers

Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo

(2013) XIAOLEI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus

(2013) Miao-Fen Chen et al.   Molecular Cancer

Epstein–Barr virus-encoded small non-coding RNAs induce cancer cell chemoresistance and migration

(2013) Aditi Sengupta Banerjee et al.   VIROLOGY

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

(2012) Ivan H. W. Ng et al.   BIOCHEMICAL JOURNAL

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

(2012) P. van Hagen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers

(2011) Teppei Morikawa et al.   CLINICAL CANCER RESEARCH

p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

(2011) Doris Schneller et al.   HEPATOLOGY

EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis

(2011) Tobias Ettl et al.   HUMAN PATHOLOGY

Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis

(2011) Katrin M Sjoquist et al.   LANCET ONCOLOGY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Antitumorigenic potential of STAT3 alternative splicing modulation

(2011) F. Zammarchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis

(2010) E. Pectasides et al.   CLINICAL CANCER RESEARCH

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

(2009) Monica Musteanu et al.   GASTROENTEROLOGY

Long-Term Results of a Randomized Trial of Surgery With or Without Preoperative Chemotherapy in Esophageal Cancer

(2009) William H. Allum et al.   JOURNAL OF CLINICAL ONCOLOGY

Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells

(2009) Zhang   Molecular Medicine Reports

Pharmacokinetics and pharmacogenomics in esophageal cancer chemoradiotherapy

(2008) Toshiyuki Sakaeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Of alphas and betas: distinct and overlapping functions of STAT3 isoforms

(2008) Sarah Dewilde   Frontiers in Bioscience-Landmark

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT