RAC1 inhibition reverses cisplatin resistance in esophageal squamous cell carcinoma and induces downregulation of glycolytic enzymes

Epidemiology of Esophageal Squamous Cell Carcinoma

(2018) Christian C. Abnet et al.   GASTROENTEROLOGY

Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

(2018) Yuan Jiang et al.   Nature Communications

Rho GTPases as therapeutic targets in cancer (Review)

(2017) G.A. Cardama et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chromosomal and Genomic Variations in Esophageal Squamous Cell Carcinoma: A Review of Technologies, Applications, and Prospections

(2017) Qi Song et al.   Journal of Cancer

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma

(2017) C-Q Li et al.   Oncogenesis

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma

(2016) Hai-Ying Zou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Warburg Effect - a Consequence or the Cause of Carcinogenesis?

(2016) Slobodan Devic   Journal of Cancer

Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells

(2015) Kohei Taniguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

(2015) Khalid O Alfarouk et al.   Cancer Cell International

The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3  in Esophageal Squamous Cell Carcinoma

(2015) H.-F. Zhang et al.   CLINICAL CANCER RESEARCH

PI3K and AKT: Unfaithful Partners in Cancer

(2015) Seraina Faes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Quantitative proteomics reveals the downregulation of GRB2 as a prominent node of F806-targeted cell proliferation network

(2015) Li-Yan Li et al.   Journal of Proteomics

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

(2015) S. Dütting et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A role for Rac1 activity in malignant progression of sebaceous skin tumors

(2015) D Frances et al.   ONCOGENE

An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis

(2015) G Zhu et al.   ONCOGENE

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

Editorial: Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

(2015) Chiara Riganti et al.   Frontiers in Oncology

Surgical treatments for esophageal cancers

(2014) William H. Allum et al.   Annals of the New York Academy of Sciences

Endoscopic Submucosal Dissection Versus Endoscopic Mucosal Resection for the Treatment of Early Esophageal Carcinoma: a Meta-analysis

(2014) Jing Wang et al.   Asian Pacific Journal of Cancer Prevention

Modulatory roles of glycolytic enzymes in cell death

(2014) Claudia Cerella et al.   BIOCHEMICAL PHARMACOLOGY

Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)

(2014) S Skvortsov et al.   BRITISH JOURNAL OF CANCER

Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistance

(2014) Le Yu et al.   CANCER LETTERS

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex

(2014) Kyongmi Um et al.   DEVELOPMENTAL CELL

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

(2014) Nasma D. Eljack et al.   Metallomics

Role of aldolase A in osteosarcoma progression and metastasis: In vitro and in vivo evidence

(2014) FENG LONG et al.   ONCOLOGY REPORTS

Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

(2013) Georgina Cardama et al.   Anti-Cancer Agents in Medicinal Chemistry

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

Altered Expression of Endogenous Soluble Vascular Endothelial Growth Factor Receptor-2 Is Involved in the Progression of Esophageal Squamous Cell Carcinoma

(2013) Zhi-Yong Wu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice

(2013) Karin Zins et al.   PLoS One

A review of the current understanding and clinical utility of miRNAs in esophageal cancer

(2013) Naomi S. Sakai et al.   SEMINARS IN CANCER BIOLOGY

The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma

(2012) Adam Gastonguay et al.   CANCER BIOLOGY & THERAPY

Externalized Glycolytic Enzymes Are Novel, Conserved, and Early Biomarkers of Apoptosis

(2012) David S. Ucker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

(2012) Brenda L. Montalvo-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular dynamics of multifunctional protein regulation: Mechanisms of GAPDH intracellular translocation

(2012) Michael A. Sirover   JOURNAL OF CELLULAR BIOCHEMISTRY

Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer

(2012) Sarat Chandarlapaty   Cancer Discovery

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

The Human Protein Atlas as a proteomic resource for biomarker discovery

(2011) F. Pontén et al.   JOURNAL OF INTERNAL MEDICINE

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer

(2010) Takao Kamai et al.   BMC CANCER

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Personalized medicine in oncology: the future is now

(2010) Richard L. Schilsky   NATURE REVIEWS DRUG DISCOVERY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Virtual Screening Approach for the Identification of New Rac1 Inhibitors

(2009) Nicola Ferri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemosensitivity of patients with recurrent esophageal cancer receiving perioperative chemotherapy

(2008) A. Takashima et al.   DISEASES OF THE ESOPHAGUS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY