Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design
Authors
Keywords
-
Journal
JOURNAL OF LIPID RESEARCH
Volume 57, Issue 8, Pages 1552-1563
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2016-06-17
DOI
10.1194/jlr.m069229
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design
- (2016) Xiaofeng Yu et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Cholesterol lowering: role in cancer prevention and treatment
- (2015) Toshiyuki Murai BIOLOGICAL CHEMISTRY
- Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs
- (2015) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis
- (2015) Galina I. Lepesheva et al. JOURNAL OF INFECTIOUS DISEASES
- Disorders of Cholesterol Metabolism and Their Unanticipated Convergent Mechanisms of Disease
- (2014) Frances M. Platt et al. Annual Review of Genomics and Human Genetics
- Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
- (2014) Aleksandra Pandyra et al. CANCER RESEARCH
- Spectrum of statin hepatotoxicity: Experience of the drug-induced liver injury network
- (2014) Mark W. Russo et al. HEPATOLOGY
- Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition
- (2014) Laura Friggeri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Statins and skeletal muscles toxicity: From clinical trials to everyday practice
- (2014) Giuseppe Danilo Norata et al. PHARMACOLOGICAL RESEARCH
- Statins in neurological disorders: An overview and update
- (2014) Anna Maria Malfitano et al. PHARMACOLOGICAL RESEARCH
- Muscle- and skeletal-related side-effects of statins: tip of the iceberg?
- (2014) Johann Auer et al. European Journal of Preventive Cardiology
- Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial
- (2013) Olöf Bjarnadottir et al. BREAST CANCER RESEARCH AND TREATMENT
- Randomized double-blinded, placebo-controlled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients
- (2013) Jung Yong Hong et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Complexes ofTrypanosoma cruziSterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease
- (2013) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metrics other than potency reveal systematic variation in responses to cancer drugs
- (2013) Mohammad Fallahi-Sichani et al. Nature Chemical Biology
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
- (2012) William A. Freed-Pastor et al. CELL
- Cholesterol and prostate cancer
- (2012) Kristine Pelton et al. CURRENT OPINION IN PHARMACOLOGY
- Statins Personalized
- (2012) H. Robert Superko et al. MEDICAL CLINICS OF NORTH AMERICA
- Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
- (2012) M. Maulik et al. MOLECULAR NEUROBIOLOGY
- Statin Use and Reduced Cancer-Related Mortality
- (2012) Sune F. Nielsen et al. NEW ENGLAND JOURNAL OF MEDICINE
- CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds
- (2012) Tatiana Y. Hargrove et al. International Journal for Parasitology-Drugs and Drug Resistance
- Biosynthesis of Cholesterol and Other Sterols
- (2011) W. David Nes CHEMICAL REVIEWS
- A Randomized Phase II Study of Gefitinib Plus Simvastatin Versus Gefitinib Alone in Previously Treated Patients with Advanced Non–Small Cell Lung Cancer
- (2011) Ji-Youn Han et al. CLINICAL CANCER RESEARCH
- Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis
- (2011) Galina I. Lepesheva et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Managing the underestimated risk of statin-associated myopathy
- (2011) Loukianos S. Rallidis et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum
- (2011) Tatiana Y. Hargrove et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hints That Statins Reduce Colon Cancer Risk Finally Being Put to the Test
- (2011) K. Hede JNCI-Journal of the National Cancer Institute
- Prospects of Statins in Parkinson Disease
- (2011) Avik Roy et al. NEUROSCIENTIST
- Structural basis for conservation in the CYP51 family
- (2010) Galina I. Lepesheva et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
- (2010) Heather A. Hirsch et al. CANCER CELL
- Statin use and cancer risk: a comprehensive review
- (2010) Denise M Boudreau et al. Expert Opinion On Drug Safety
- Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi
- (2010) Galina I. Lepesheva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis of Human CYP51 Inhibition by Antifungal Azoles
- (2010) Natallia Strushkevich et al. JOURNAL OF MOLECULAR BIOLOGY
- Conazoles
- (2010) Jan Heeres et al. MOLECULES
- Statin-Associated Muscle-Related Adverse Effects: A Case Series of 354 Patients
- (2010) Stephanie Cham et al. PHARMACOTHERAPY
- Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections
- (2009) Galina I. Lepesheva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease
- (2009) James M. Kraus et al. JOURNAL OF MEDICINAL CHEMISTRY
- Association between plasma cholesterol and prostate cancer in the PSA era
- (2008) Elizabeth A. Platz et al. INTERNATIONAL JOURNAL OF CANCER
- Statins induce lethal effects in acute myeloblastic leukemia cells within 72 hours
- (2008) Lillian P. Burke et al. LEUKEMIA & LYMPHOMA
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started