Bacterial second messenger c-di-GMP: Emerging functions in stress resistance

Microbial exopolymeric substances and biosurfactants as ‘bioavailability enhancers’ for polycyclic aromatic hydrocarbons biodegradation

(2022) P. J. Yesankar et al.   International Journal of Environmental Science and Technology

Recent Progress in Bile Acid-Based Antimicrobials

(2021) Caihong Lin et al.   BIOCONJUGATE CHEMISTRY

High-Specificity Local and Global c-di-GMP Signaling

(2021) Regine Hengge   TRENDS IN MICROBIOLOGY

Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance

(2021) S. Katharios-Lanwermeyer et al.   mBio

The two‐component system TarR–TarS is regulated by c‐di‐GMP / FleQ and FliA and modulates antibiotic susceptibility in Pseudomonas putida

(2021) Yujie Xiao et al.   ENVIRONMENTAL MICROBIOLOGY

Bacterial cyclic diguanylate signaling networks sense temperature

(2021) Henrik Almblad et al.   Nature Communications

PAS domains in bacterial signal transduction

(2021) Erwin C Stuffle et al.   CURRENT OPINION IN MICROBIOLOGY

Rugose small colony variant and its hyper-biofilm in Pseudomonas aeruginosa: Adaption, evolution, and biotechnological potential

(2021) Anming Xu et al.   BIOTECHNOLOGY ADVANCES

Bacterial adaptive strategies to cope with metal toxicity in the contaminated environment – A review

(2021) Krishnamurthy Mathivanan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction

(2021) Trevor E. Randall et al.   JOURNAL OF BACTERIOLOGY

An Intracellular Sensing and Signal Transduction System That Regulates the Metabolism of Polycyclic Aromatic Hydrocarbons in Bacteria

(2021) Wanpeng Wang et al.   mSystems

Azorhizobium caulinodans c-di-GMP phosphodiesterase Chp1 involved in motility, EPS production, and nodulation of the host plant

(2020) Yu Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

(2020) Gukui Chen et al.   EMBO JOURNAL

Biofilm dispersion

(2020) Kendra P. Rumbaugh et al.   NATURE REVIEWS MICROBIOLOGY

The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production

(2020) Roman Thibeaux et al.   npj Biofilms and Microbiomes

Surviving Reactive Chlorine Stress: Responses of Gram-Negative Bacteria to Hypochlorous Acid

(2020) Waleska Stephanie da Cruz Nizer et al.   Microorganisms

Thermoregulation of Biofilm Formation in Pseudomonas aeruginosa

(2020) Suran Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Multicellular String-Like Structure Formation by Salmonella Typhimurium Depends on Cellulose Production: Roles of Diguanylate Cyclases, YedQ and YfiN

(2020) Alan Varghese et al.   Frontiers in Microbiology

Crosstalking second messengers

(2020) Regine Hengge   Nature Microbiology

Cyclic-di-GMP regulation promotes survival of a slow-replicating subpopulation of intracellularSalmonellaTyphimurium

(2019) Erik Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

(2019) Oana Ciofu et al.   Frontiers in Microbiology

Cyclic DI-GMP Increases Catalase Production and Hydrogen Peroxide Tolerance in Vibrio cholerae

(2019) Nicolas L. Fernandez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biofilms: The Microbial “Protective Clothing” in Extreme Environments

(2019) Wen Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclic di-GMP co-activates the two-component transcriptional regulator DevR in Mycobacterium smegmatis in response to oxidative stress

(2019) Qingbin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Salmonella resistance to bile during biofilm formation

(2019) Ming-Han Tsai et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

The Response of Cupriavidus metallidurans CH34 to Cadmium Involves Inhibition of the Initiation of Biofilm Formation, Decrease in Intracellular c-di-GMP Levels, and a Novel Metal Regulated Phosphodiesterase

(2019) Pablo Alviz-Gazitua et al.   Frontiers in Microbiology

Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis

(2019) Martina Valentini et al.   Annual Review of Microbiology

Bacterial stress defense: the crucial role of ribosome speed

(2019) Manlu Zhu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

High c-di-GMP promotes expression of fpr-1 and katE involved in oxidative stress resistance in Pseudomonas putida KT2440

(2019) Yujie Xiao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair

(2019) Jiaquan Liu et al.   Nature Communications

Role of Cyclic di-GMP in the Bacterial Virulence and Evasion of the Plant Immunity

(2018) Marta Martinez-Gil et al.   CURRENT ISSUES IN MOLECULAR BIOLOGY

Cyclic di-GMP Positively Regulates DNA Repair in Vibrio cholerae

(2018) Nicolas L. Fernandez et al.   JOURNAL OF BACTERIOLOGY

HpoR, a novel c-di-GMP effective transcription factor, links the second messenger’s regulatory function to the mycobacterial antioxidant defense

(2018) Weihui Li et al.   NUCLEIC ACIDS RESEARCH

Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense

(2018) Weihui Li et al.   NUCLEIC ACIDS RESEARCH

BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin

(2018) Feng Wang et al.   Nature Communications

Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection

(2018) Guohui Xiao et al.   Frontiers in Microbiology

bifA Regulates Biofilm Development of Pseudomonas putida MnB1 as a Primary Response to H2O2 and Mn2+

(2018) Yanjing Zheng et al.   Frontiers in Microbiology

The PA3177 Gene Encodes an Active Diguanylate Cyclase That Contributes to Biofilm Antimicrobial Tolerance but Not Biofilm Formation by Pseudomonas aeruginosa

(2018) Bandita Poudyal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

(2018) Zheng Pang et al.   BIOTECHNOLOGY ADVANCES

AU-Rich Long 3′ Untranslated Region Regulates Gene Expression in Bacteria

(2018) Ju-Ping Zhao et al.   Frontiers in Microbiology

Harnessing Metabolic Regulation to Increase Hfq-Dependent Antibiotic Susceptibility in Pseudomonas aeruginosa

(2018) Petra Pusic et al.   Frontiers in Microbiology

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

The stringent response promotes biofilm dispersal in Pseudomonas putida

(2017) Carlos Díaz-Salazar et al.   Scientific Reports

A Bacterial Receptor PcrK Senses the Plant Hormone Cytokinin to Promote Adaptation to Oxidative Stress

(2017) Fang-Fang Wang et al.   Cell Reports

The Oxidative Stress Agent Hypochlorite Stimulates c-di-GMP Synthesis and Biofilm Formation in Pseudomonas aeruginosa

(2017) Nikola Strempel et al.   Frontiers in Microbiology

p-Cymene Promotes Its Catabolism through the p-Cymene and the p-Cumate Pathways, Activates a Stress Response and Reduces the Biofilm Formation in Burkholderia xenovorans LB400

(2017) Loreine Agulló et al.   PLoS One

Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide

(2017) Hai-Nan Zhang et al.   Scientific Reports

Influence of 3-Chloroaniline on the Biofilm Lifestyle of Comamonas testosteroni and Its Implications on Bioaugmentation

(2016) Yichao Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Copper Resistance of the Emerging Pathogen Acinetobacter baumannii

(2016) Caitlin L. Williams et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial Stress Responses during Host Infection

(2016) Ferric C. Fang et al.   Cell Host & Microbe

Regulation of Growth, Cell Shape, Cell Division, and Gene Expression by Second Messengers (p)ppGpp and Cyclic Di-GMP in Mycobacterium smegmatis

(2016) Kuldeepkumar Ramnaresh Gupta et al.   JOURNAL OF BACTERIOLOGY

The hmsT 3′ untranslated region mediates c-di-GMP metabolism and biofilm formation in Y ersinia pestis

(2016) Hui Zhu et al.   MOLECULAR MICROBIOLOGY

Reactive oxygen species, abiotic stress and stress combination

(2016) Feroza K. Choudhury et al.   PLANT JOURNAL

Degradation of cyclic diguanosine monophosphate by a hybrid two-component protein protectsAzoarcussp. strain CIB from toluene toxicity

(2016) Zaira Martín-Moldes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

(2016) Song Lin Chua et al.   Open Biology

Novel Functions of (p)ppGpp and Cyclic di-GMP in Mycobacterial Physiology Revealed by Phenotype Microarray Analysis of Wild-Type and Isogenic Strains of Mycobacterium smegmatis

(2015) Kuldeepkumar Ramnaresh Gupta et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Temperature affects c-di-GMP signalling and biofilm formation inVibrio cholerae

(2015) Loni Townsley et al.   ENVIRONMENTAL MICROBIOLOGY

Identification and Characterization of VpsR and VpsT Binding Sites in Vibrio cholerae

(2015) David Zamorano-Sánchez et al.   JOURNAL OF BACTERIOLOGY

FleQ DNA Binding Consensus Sequence Revealed by Studies of FleQ-Dependent Regulation of Biofilm Gene Expression in Pseudomonas aeruginosa

(2015) Claudine Baraquet et al.   JOURNAL OF BACTERIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Whole-genome analysis of Azoarcus sp. strain CIB provides genetic insights to its different lifestyles and predicts novel metabolic features

(2015) Zaira Martín-Moldes et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity

(2015) Weihui Li et al.   Nature Communications

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

(2015) Song Lin Chua et al.   Scientific Reports

Distinct Responses of Mycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide

(2015) Xiaojing Li et al.   PLoS One

Elevated level of the second messenger c-di-GMP in Comamonas testosteroni enhances biofilm formation and biofilm-based biodegradation of 3-chloroaniline

(2014) Yichao Wu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cyclic-di-GMP levels affectPseudomonas aeruginosafitness in the presence of imipenem

(2014) Gianlucca G. Nicastro et al.   ENVIRONMENTAL MICROBIOLOGY

Bile Acids and Bicarbonate Inversely Regulate Intracellular Cyclic di-GMP in Vibrio cholerae

(2014) Benjamin J. Koestler et al.   INFECTION AND IMMUNITY

Elevated levels of the second messenger c-di-GMP contribute to antimicrobial resistance ofPseudomonas aeruginosa

(2014) Kajal Gupta et al.   MOLECULAR MICROBIOLOGY

The c-di-GMP phosphodiesterase BifA regulates biofilm development inPseudomonas putida

(2014) Alicia Jiménez-Fernández et al.   Environmental Microbiology Reports

Cyclic di-GMP-dependent Signaling Pathways in the Pathogenic Firmicute Listeria monocytogenes

(2014) Li-Hong Chen et al.   PLoS Pathogens

Bis-(3′-5′)-Cyclic Dimeric GMP Regulates Antimicrobial Peptide Resistance in Pseudomonas aeruginosa

(2013) Song Lin Chua et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and characterization of starvation induced msdgc-1 promoter involved in the c-di-GMP turnover

(2013) Binod K. Bharati et al.   GENE

Antimicrobial Tolerance of Pseudomonas aeruginosa Biofilms Is Activated during an Early Developmental Stage and Requires the Two-Component Hybrid SagS

(2013) K. Gupta et al.   JOURNAL OF BACTERIOLOGY

The MerR-Like Regulator BrlR Confers Biofilm Tolerance by Activating Multidrug Efflux Pumps in Pseudomonas aeruginosa Biofilms

(2013) J. Liao et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

YjcC, a c-di-GMP Phosphodiesterase Protein, Regulates the Oxidative Stress Response and Virulence of Klebsiella pneumoniae CG43

(2013) Ching-Jou Huang et al.   PLoS One

Bacterial stress responses as determinants of antimicrobial resistance

(2012) K. Poole   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Tangled Web: Regulatory Connections between Quorum Sensing and Cyclic Di-GMP

(2012) D. Srivastava et al.   JOURNAL OF BACTERIOLOGY

The bacterial second messenger c-di-GMP: mechanisms of signalling

(2011) Erez Mills et al.   CELLULAR MICROBIOLOGY

Antibiotic-Induced Biofilm Formation

(2011) Jeffrey B. Kaplan   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain

(2010) S. An et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a c-di-GMP-Regulated Polysaccharide Locus Governing Stress Resistance and Biofilm and Rugose Colony Formation in Vibrio vulnificus

(2010) Y. Guo et al.   INFECTION AND IMMUNITY

Escherichia coli K-12 YfgF is an anaerobic cyclic di-GMP phosphodiesterase with roles in cell surface remodelling and the oxidative stress response

(2010) M. M. Lacey et al.   MICROBIOLOGY-SGM

The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation

(2010) Laty A. Cahoon et al.   MOLECULAR MICROBIOLOGY

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

SiaA and SiaD are essential for inducing autoaggregation as a specific response to detergent stress inPseudomonas aeruginosa

(2009) Janosch Klebensberger et al.   ENVIRONMENTAL MICROBIOLOGY

Second messenger signalling governsEscherichia colibiofilm induction upon ribosomal stress

(2009) Alex Boehm et al.   MOLECULAR MICROBIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Bacterial Degradation of Aromatic Compounds

(2009) Jong-Su Seo et al.   International Journal of Environmental Research and Public Health

Identification of a Bile-Induced Exopolysaccharide Required for Salmonella Biofilm Formation on Gallstone Surfaces

(2008) R. W. Crawford et al.   INFECTION AND IMMUNITY