TNFα-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2

Lipocalin‐2 Activates Hepatic stellate cells and Promotes Non‐alcoholic Steatohepatitis in High‐Fat Diet‐Fed ob/ob mice

(2022) Kyung Eun Kim et al.   HEPATOLOGY

A human adipose tissue cell-type transcriptome atlas

(2022) Marthe Norreen-Thorsen et al.   Cell Reports

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

(2021) Andrew D. Hildreth et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance

(2021) Luan Américo-Da-Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipocalin-2 Alleviates LPS-Induced Inflammation Through Alteration of Macrophage Properties

(2021) Huahua Du et al.   Journal of Inflammation Research

Lipocalin-2: Structure, function, distribution and role in metabolic disorders

(2021) Saeeda Al Jaberi et al.   BIOMEDICINE & PHARMACOTHERAPY

Depletion of Lipocalin 2 (LCN2) in Mice Leads to Dysbiosis and Persistent Colonization with Segmented Filamentous Bacteria

(2021) Patrick Klüber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion

(2021) Houyou Yu et al.   Frontiers in Pharmacology

Caspase-1 as a regulatory molecule of lipid metabolism

(2020) Meseret Derbew Molla et al.   Lipids in Health and Disease

Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice

(2020) Myoung Seok Ko et al.   Autophagy

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

(2020) Tania Romacho et al.   Scientific Reports

Small molecule‐driven SIRT3‐autophagy mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes

(2020) Tian Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis

(2020) Ayan Mondal et al.   Journal of Neuroinflammation

Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases

(2020) Duc-Vinh Pham et al.   ARCHIVES OF PHARMACAL RESEARCH

Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation

(2020) De-Li ZhuGe et al.   ARCHIVES OF PHARMACAL RESEARCH

Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4

(2020) Pedro M. Moraes-Vieira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

(2019) Weilin Xu et al.   Journal of Neuroinflammation

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes

(2018) Erfei Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice

(2016) M C Morrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2

(2016) Dewei Ye et al.   JOURNAL OF HEPATOLOGY

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances

(2016) Franz Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Lipocalin-2 inhibits autophagy and induces insulin resistance in H9c2 cells

(2016) Yee Kwan Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

The Induction of Lipocalin-2 Protein Expressionin Vivoandin Vitro

(2014) Peng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1

(2013) Paiboon Jitprasertwong et al.   CYTOKINE

STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes

(2013) Peng Zhao et al.   Molecular Metabolism

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1  Transcription in Human Adipose Tissue

(2011) T. B. Koenen et al.   DIABETES

Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans

(2011) B. Meissburger et al.   DIABETOLOGIA

Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation

(2011) Guoxiong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Upregulation of Lipocalin 2 in Adipose Tissues of Severely Obese Women: Positive Relationship With Proinflammatory Cytokines

(2011) Teresa Auguet et al.   Obesity

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Adipose tissue remodeling in pathophysiology of obesity

(2010) Mi-Jeong Lee et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

(2010) I. K.M. Law et al.   DIABETES

Lipocalin 2 is essential for chronic kidney disease progression in mice and humans

(2010) Amandine Viau et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB

(2010) Minori Tamai et al.   LABORATORY INVESTIGATION

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

(2009) V. Catalán et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Caspase-mediated Degradation of PPARγ Proteins in Adipocytes

(2008) Fang He et al.   Obesity