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Caspase-1 as a regulatory molecule of lipid metabolism

LIPIDS IN HEALTH AND DISEASE (2020)

Journal

LIPIDS IN HEALTH AND DISEASE

Volume 19, Issue 1, Pages -

Publisher

BMC

DOI: 10.1186/s12944-020-01220-y

Keywords

Caspase-1; Lipid metabolism; Inflammasome; Transcriptional factors

Categories

Biochemistry & Molecular Biology Nutrition & Dietetics

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Abstract

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the proinflammatory cytokines; interleukin 1 beta (IL-1 beta) and interluekine-18 (IL-18). In addition to IL-1 beta and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

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Rao, Sina Rashedi, Mohammad-Mahdi Rashidi, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Misganu Teshoma Regasa, Andre M. N. Renzaho, Maryam Rezaei, Nima Rezaei, Mohsen Rezaeian, Aziz Rezapour, Sahba Rezazadeh-Khadem, Abanoub Riad, Ligia Estefania Rios Lopez, Jefferson Antonio Buendia Rodriguez, Luca Ronfani, Gholamreza Roshandel, Godfrey M. Rwegerera, Maha Mohamed Saber-Ayad, Siamak Sabour, Basema Saddik, Erfan Sadeghi, Saeid Sadeghian, Umar Saeed, Amirhossein Sahebkar, K. M. Saif-Ur-Rahman, S. Mohammad Sajadi, Sarvenaz Salahi, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Francesco Sanmarchi, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Susan M. Sawyer, Mete Saylan, Ione Jayce Ceola Schneider, Abdul-Aziz Seidu, Mario Sekerija, Endalew Gemechu Sendo, Sadaf G. Sepanlou, Allen Seylani, Kenbon Seyoum, Feng Sha, Omid Shafaat, Masood Ali Shaikh, Erfan Shamsoddin, Mohammed Shannawaz, Rajesh Sharma, Sara Sheikhbahaei, Adithi Shetty, B. Suresh Kumar Shetty, Pavanchand H. Shetty, Jae Il Shin, Reza Shirkoohi, K. M. Shivakumar, Parnian Shobeiri, Soraya Siabani, Migbar Mekonnen Sibhat, Sudeep K. Siddappa Malleshappa, Negussie Boti Sidemo, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A. Singh, Jitendra Kumar Singh, Surjit Singh, Abiy H. Sinke, Yitagesu Sintayehu, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Lee Smith, Ahmad Sofi-Mahmudi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Emma Elizabeth Spurlock, Paschalis Steiropoulos, Kurt Straif, Ranjeeta Subedi, Mu'awiyyah Babale Sufiyan, Rizwan Suliankatchi Abdulkader, Saima Sultana, Viktoria Szerencses, Miklos Szocska, Seidamir Pasha Tabaeian, Rafael Tabaras-Seisdedos, Mohammadreza Tabary, Takahiro Tabuchi, Hooman Tadbiri, Majid Taheri, Amir Taherkhani, Ken Takahashi, Mircea Tampa, Ker-Kan Tan, Vivian Y. Tat, Ahmad Tavakoli, Abdelghani Tbakhi, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Fisaha Haile Tesfay, Bekele Tesfaye, Jarnail Singh Thakur, Rekha Thapar, Aravind Thavamani, Arulmani Thiyagarajan, Nihal Thomas, Ruoyan Tobe-Gai, Munkhsaikhan Togtmol, Seyed Abolfazl Tohidast, Hamid Reza Tohidinik, Musliu Adetola Tolani, Daniel Nigusse Tollosa, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Biruk Shalmeno Tusa, Gebresilasea Gendisha Ukke, Irfan Ullah, Saif Ullah, Krishna Kishore Umapathi, Bhaskaran Unnikrishnan, Era Upadhyay, Tolassa Wakayo Ushula, Marco Vacante, Sahel Valadan Tahbaz, Shoban Babu Varthya, Massimiliano Veroux, Paul J. Villeneuve, Francesco S. Violante, Vasily Vlassov, Giang Thu Vu, Yasir Waheed, Ning Wang, Paul Ward, Adisu Birhanu Weldesenbet, Yi Feng Wen, Ronny Westerman, Andrea Sylvia Winkler, Befikadu Legesse Wubishet, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Sanni Yaya, Vahid Yazdi-Feyzabadi, Taklo Simeneh Yazie, Sisay Shewasinad Yehualashet, Alex Yeshaneh, Yigizie Yeshaw, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Mustafa Z. Younis, Zabihollah Yousefi, Chuanhua Yu, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Telma Zahirian Moghadam, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Fariba Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Jianrong Zhang, Zhi-Jiang Zhang, Arash Ziapour, Mohammad Zoladl, Christopher J. L. Murray, Christina Fitzmaurice, Archie Bleyer, Nickhill Bhakta, Teferi Gebru Gebremeskel

Summary: This study provides comprehensive data on the burden of cancer among adolescents and young adults globally. The results show that in 2019, there were 1.19 million incident cancer cases and 396,000 cancer deaths among individuals aged 15-39 years worldwide. Cancer was the fourth leading cause of death and tenth leading cause of disability-adjusted life-years (DALYs) in this age group.

LANCET ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis cases at Jimma University Medical Center, Southwest Ethiopia

Wasihun Admassu, Birhanu Ayelign, Gemeda Abebe, Mulualem Tadesse

Summary: This retrospective study investigated the use of Xpert MTB/RIF assay for the diagnosis of tuberculosis (TB) and drug resistance in a heterogeneous group of patients and sample types in Ethiopia. The results showed a relatively low overall frequency of Mycobacterium tuberculosis (MTB) and rifampicin resistance compared to previous reports. However, better diagnostic tools and approaches are still needed to address the burden of TB and drug-resistant TB in the country.

PLOS ONE (2022)

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Article Cell Biology

Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells

Kristie Kim, Tesfahun Dessale Admasu, Alexandra Stolzing, Amit Sharma

Summary: In the context of aging and age-related diseases, Natural Killer (NK) cells have been identified as a crucial cell type for immune clearance of senescent cells. NK cell-based therapies have emerged as promising alternatives to drug-based treatments for age-related diseases and debility.

AGING-US (2022)

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Article Medicine, General & Internal

Progress in health among regions of Ethiopia, 1990-2019: a subnational country analysis for the Global Burden of Disease Study 2019

Awoke Misganaw, Alemnesh H. Mirkuzie, Ababi Zergaw Giref, Tezera Moshago Berheto, Ebba Abate Waktola, John H. Kempen, Getachew Tollera Eticha, Tsigereda Kifle Wolde, Dereje Deguma, Kalkidan Hassen Abate, Kedir Hussein Abegaz, Muktar Beshir Ahmed, Yonas Akalu, Addis Aklilu, Biresaw Wassihun Alemu, Mulusew A. Asemahagn, Atalel Fentahun Awedew, Senthilkumar Balakrishnan, Tariku Tesfaye Bekuma, Addisu Shunu Beyene, Misrak Getnet Beyene, Yihienew Mequanint Bezabih, Biruk Tesfaye Birhanu, Tesfaye Yitna Chichiabellu, Berihun Assefa Dachew, Amare Belachew Dagnew, Feleke Mekonnen Demeke, Getu Debalkie Demissie, Meseret Derbew Molla, Nebiyu Dereje, Kebede Deribe, Abebaw Alemayehu Desta, Munir Kassa Eshetu, Tomas Y. Ferede, Eyob Alemayehu Gebreyohannes, Abraham Geremew, Hailay Abrha Gesesew, Lemma Getacher, Scott D. Glenn, Aregash Samuel Hafebo, Abdiwahab Hashi, Hamid Yimam Hassen, Simon I. Hay, Diriba Fufa Hordofa, Dawit Hoyiso Huluko, Ayele Semachew Kasa, Getinet Kassahun Azene, Ermiyas Mulu Kebede, Hafte Kahsay Kebede, Bayew Kelkay, Samuel Z. Kidane, Samson Mideksa Legesse, Wondimu Ayele Manamo, Yohannes Adama A. Melaku, Endalkachew Worku Mengesha, Sisay Derso Mengesha, Hayimro Edemealem Merie, Abera M. Mersha, Amanual Getnet Mersha, Mizan Kiros Mirutse, Ammas Siraj Mohammed, Hussen Mohammed, Salahuddin Mohammed, Henok Biresaw Netsere, Dabere Nigatu, Mohammed Suleiman Obsa, Daniel Bogale Odo, Muktar Omer, Lemma Demissie Regassa, Biniyam Sahiledengle, Mohammed Feyisso Shaka, Wondimeneh Shibabaw Shiferaw, Negussie Boti Sidemo, Abiy H. Sinke, Yitagesu Sintayehu, Muluken Bekele Sorrie, Birkneh Tilahun Tadesse, Eyayou Girma Tadesse, Zemenu Tamir, Animut Tagele Tamiru, Amare Abera Tareke, Yonas Getaye Tefera, Yohannes Tekalegn, Ayenew Kassie Tesema, Tefera Tadele Tesema, Fisaha Haile Tesfay, Zemenu Tadesse Tessema, Tadesse Tilahun, Gebiyaw Wudie Tsegaye, Biruk Shalmeno Tusa, Geremew Tassew Weledesemayat, Taklo Simeneh Yazie, Yordanos Gizachew Yeshitila, Birhanu Wubale Yirdaw, Desalegn Tegabu Zegeye, Christopher J. L. Murray, Lia Tadesse Gebremedhin

Summary: Health in Ethiopia has shown significant improvements across regions and chartered cities over the past three decades, but progress in socioeconomic status, life expectancy, total fertility rate, premature mortality, disability, and risk factors has not been uniform. In 2019, leading causes of premature mortality included neonatal disorders, diarrhoeal diseases, lower respiratory infections, tuberculosis, stroke, HIV/AIDS, ischaemic heart disease, cirrhosis, congenital defects, and diabetes. Public health strategies and interventions should be tailored to address regional disparities to achieve national and regional health goals.

LANCET (2022)

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Review Cell Biology

Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions

Ashley Brauning, Michael Rae, Gina Zhu, Elena Fulton, Tesfahun Dessale Admasu, Alexandra Stolzing, Amit Sharma

Summary: Aging is a major risk factor for chronic diseases, and immunosenescence, including age-related natural killer (NK) cell dysfunction, plays a significant role in age-related morbidity and mortality. NK cell dysfunction is implicated in the increasing burden of infection, malignancy, inflammatory disorders, and senescent cells with age. Understanding the interplay between systemic inflammation, senescence burden, and NK cell dysfunction can potentially lead to therapies countering age-related diseases and underlying biological aging processes.

CELLS (2022)

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Article Health Care Sciences & Services

Hypertension and Its Associated Factors Among Cancer Patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: Hospital-Based Cross-Sectional Study

Anteneh Ayelign Kibret, Hailu Aragie, Daniel Gashaneh Belay, Meseret Derbew Molla, Ephrem Tafesse Teferi, Endalkachew Belayneh Melese, Yilkal Belete Worku, Haileab Fekadu Wolde, Dagnew Getnet Adugna

Summary: This study aimed to assess the prevalence and associated factors of hypertension among cancer patients in Ethiopia. The results showed a considerably high prevalence of hypertension among cancer patients, which was significantly associated with age greater than 57 years and having a family history of hypertension. Therefore, it is important to screen and prevent hypertension in high-risk cancer patients.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2022)

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Article Oncology

Evaluation of total oxidative stress and antioxidant capacity of brain tumour patients attending referral hospitals in Addis Ababa, 2020: a comparative cross-sectional study

Fitalew Tadele Admasu, Biruk Demissie, Getachew Yideg Yitbarek, Zeleke Geto, Aragaw Tesfaw, Edget Abebe Zewde, Animut Tilahun, Gashaw Walle, Tigist Tefera Bekele, Mezgebu Legesse Habte, Teka Obsa Feyisa, Tadeg Jemere Amare, Wubet Alebachew, Sintayehu Asnakew, Ermiyas Sisay, Markeshaw Tiruneh, Getaneh Atikilt Yemata, Tigabu Munye Aytenew, Tadesse Asmamaw Dejenie

Summary: This study found higher levels of oxidants and lower levels of antioxidants in the serum of brain tumor patients compared to the control group. The post-surgery oxidant levels were lower than the pre-surgery levels. These findings suggest that redox imbalance may play a role in the pathophysiology of brain tumors.

ECANCERMEDICALSCIENCE (2022)

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Article Gastroenterology & Hepatology

Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Brittney S. Sheena, Lindsey Hiebert, Hannah Han, Helen Ippolito, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Amir Abdoli, Hiwa Abubaker Ali, Mesafint Molla Adane, Oyelola A. Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M. Advani, Muhammad Sohail Afzal, Saira Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Tauseef Ahmad, Sepideh Ahmadi, Haroon Ahmed, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Gizachew Taddesse Akalu, Addis Aklilu, Tayyaba Akram, Hanadi Al Hamad, Fares Alahdab, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Fadwa Alhalaiqa Naji Alhalaiqa, Robert Kaba Alhassan, Liaqat Ali, Muhammad Ashar Ali, Yousef Alimohamadi, Vahid Alipour, Motasem Alkhayyat, Sami Almustanyir, Rajaa M. Al-Raddadi, Haya Altawalah, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Amir Anoushiravani, Adnan Ansar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Zeleke Gebru Argaw, Muhammad Arshad, Anton A. Artamonov, Tahira Ashraf, Daniel Atlaw, Floriane Ausloos, Marcel Ausloos, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ghasem Azarian, Sayna Bagheri, Saeed Bahadory, Atif Amin Baig, Maciej Banach, Nastaran Barati, Amadou Barrow, Abdul-Monim Mohammad Batiha, Diana Fernanda Bejarano Ramirez, Uzma Iqbal Belgaumi, Alemshet Yirga Berhie, Devidas S. Bhagat, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Vijayalakshmi S. Bhojaraja, Ali Bijani, Antonio Biondi, Belay Boda Abule Bodicha, Hunduma Amensisa Bojia, Archith Boloor, Cristina Bosetti, Dejana Braithwaite, Nikolay Ivanovich Briko, Zahid A. Butt, Luis Alberto Camera, Raja Chandra Chakinala, Promit Ananyo Chakraborty, Jaykaran Charan, Shu Chen, Jee-Young Jasmine Choi, Sonali Gajanan Choudhari, Fazle Rabbi Chowdhury, Dinh-Toi Chu, Sheng-Chia Chung, Paolo Angelo Cortesi, Benjamin C. Cowie, Garland T. Culbreth, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Fernando Pio De la Hoz, Sisay Abebe Debela, Mohammed Gebre Dedefo, Feleke Mekonnen Demeke, Takele Gezahegn G. Demie, Getu Debalkie Demissie, Meseret Derbew Molla, Abebaw Alemayehu Desta, Deepak Dhamnetiya, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mojtaba Didehdar, Linh Phuong Doan, Fariba Dorostkar, Thomas M. Drake, Fatemeh Eghbalian, Michael Ekholuenetale, Iman El Sayed, Maysaa El Sayed Zaki, Muhammed Elhadi, Mohamed A. Elmonem, Aisha Elsharkawy, Shymaa Enany, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Sharareh Eskandarieh, Firooz Esmaeilzadeh, Sayeh Ezzikouri, Hossein Farrokhpour, Getahun Fetensa, Florian Fischer, Masoud Foroutan, Mohamed M. Gad, Abhay Motiramji Gaidhane, Shilpa Gaidhane, Natalie C. Galles, Silvano Gallus, Teferi Gebru Gebremeskel, Eyob Alemayehu Gebreyohannes, Keyghobad Ghadiri, Kazem Ghaffari, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Ali Gholami, Abdolmajid Gholizadeh, Aima Gilani, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Giuseppe Gorini, Yitayal Ayalew Goshu, Max G. Griswold, Mohammed Ibrahim Mohialdeen Gubari, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Rabih Halwani, Saeed S. Hamid, Samer Hamidi, Asif Hanif, Shafiul Haque, Harapan Harapan, Arief Hargono, Sanam Hariri, Ahmed Hasaballah, S. M. Mahmudul Hasan, Soheil Hassanipour, Hadi Hassankhani, Simon Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Ramesh Holla, Mohammad-Salar Hosseini, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Mowafa Househ, Junjie Huang, Nawfal R. Hussein, Ivo Iavicoli, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Lalu Muhammad Irham, Jessica Y. Islam, Nahlah Elkudssiah Ismail, Kathryn H. Jacobsen, Farhad Jadidi-Niaragh, Amirreza Javadi Mamaghani, Shubha Jayaram, Ranil Jayawardena, Rime Jebai, Ravi Prakash Jha, Nitin Joseph, Farahnaz Joukar, Billingsley Kaambwa, Ali Kabir, Zubair Kabir, Rohollah Kalhor, Himal Kandel, Tesfaye K. Tesfaye Kanko, Rami S. Kantar, Ibraheem M. Karaye, Bekalu Getnet Kassa, Phillip M. Kemp Bohan, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Gulfaraz Khan, Imteyaz A. Khan, Junaid Khan, Moien Ab Khan, Javad Khanali, Amir M. Khater, Mahalaqua Nazli Khatib, Mahmoud Khodadost, Abdullah T. Khoja, Omid Khosravizadeh, Jagdish Khubchandani, Gyu Ri Kim, Hanna Kim, Min Seo Kim, Yun Jin Kim, Jonathan M. Kocarnik, Ali-Asghar Kolahi, Rajasekaran Koteeswaran, G. Anil Kumar, Carlo La Vecchia, Dharmesh Kumar Lal, Ivan Landires, Savita Lasrado, Jeffrey Lazarus, Caterina Ledda, Doo Woong Lee, Sang-woong Lee, Yeong Yeh Lee, Miriam Levi, Jiarui Li, Stephen S. Lim, Stany W. Lobo, Platon D. Lopukhov, Joana A. Loureiro, Jennifer H. MacLachlan, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Azeem Majeed, Alaa Makki, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Fariborz Mansour-Ghanaei, Mohammad Ali Mansournia, Francisco Rogerlandio Martins-Melo, Philippa C. Matthews, Walter Mendoza, Ritesh G. Menezes, Tuomo J. Meretoja, Amanual Getnet Mersha, Tomislav Mestrovic, Ted R. Miller, Le Huu Nhat Minh, Andreea Mirica, Seyyedmohammadsadeq Mirmoeeni, Erkin M. Mirrakhimov, Sanjeev Misra, Prasanna Mithra, Babak Moazen, Ashraf Mohamadkhani, Mokhtar Mohammadi, Shafiu Mohammed, Nagabhishek Moka, Ali H. Mokdad, Jalal Moludi, Sara Momtazmanesh, Lorenzo Monasta, Ghobad Moradi, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Paula Moraga, Ebrahim Mostafavi, Sumaira Mubarik, Malaisamy Muniyandi, Christopher J. L. Murray, Mohsen Naghavi, Mukhammad David Naimzada, Sreenivas Narasimha Swamy, Zuhair S. Natto, Biswa Prakash Nayak, Javad Nazari, Ionut Negoi, Serban Mircea Negru, Seyed Aria Nejadghaderi, Sandhya Neupane Kandel, Huong Lan Thi Nguyen, Che Henry Ngwa, Robina Khan Niazi, Chukwudi A. Nnaji, Jean Jacques Noubiap, Ali Nowroozi, Virginia Nunez-Samudio, Bogdan Oancea, Chimedsuren Ochir, Oluwakemi Ololade Odukoya, In-Hwan Oh, Andrew T. Olagunju, Babayemi Oluwaseun Olakunde, Ahmed Omar Bali, Emad Omer, Stanislav S. Otstavnov, Bilcha Oumer, Jagadish Rao Padubidri, Adrian Pana, Anamika Pandey, Eun-Cheol Park, Fatemeh Pashazadeh Kan, Urvish K. Patel, Uttam Paudel, Ionela-Roxana Petcu, Zahra Zahid Piracha, Richard Charles G. Pollok, Maarten J. Postma, Akram Pourshams, Hossein Poustchi, Mohammad Rabiee, Navid Rabiee, Alireza Rafiei, Sima Rafiei, Pavan Manibettu Raghuram, Mosiur Rahman, Amir Masoud Rahmani, Setyaningrum Rahmawaty, Aashish Rajesh, Priyanga Ranasinghe, Chythra R. Rao, Sowmya J. Rao, Mahsa Rashidi, Mohammad-Mahdi Rashidi, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Negar Rezaei, Aziz Rezapour, Sahba Rezazadeh-Khadem, Jefferson Antonio Buendia Rodriguez, Godfrey M. Rwegerera, Siamak Sabour, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Amirhossein Sahebkar, Km Saif-Ur-Rahman, Sarvenaz Salahi, Hamideh Salimzadeh, Chethan Sampath, Abdallah M. Samy, Juan Sanabria, Francesco Sanmarchi, Milena M. Santric-Milicevic, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Abdul-Aziz Seidu, Sadaf G. Sepanlou, Allen Seylani, Saeed Shahabi, Masood Ali Shaikh, Elaheh Shaker, Murad Ziyaudinovich Shakhmardanov, Mohammed Shannawaz, Suchitra M. Shenoy, Jeevan K. Shetty, Pavanchand H. Shetty, Kenji Shibuya, Jae Il Shin, Parnian Shobeiri, Migbar Mekonnen Sibhat, Achintya Dinesh Singh, Jasvinder A. Singh, Surjit Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amir Ali Sohrabpour, Suhang Song, Seidamir Pasha Tabaeian, Eyayou Girma Tadesse, Majid Taheri, Mircea Tampa, Ker-Kan Tan, Ahmad Tavakoli, Abdelghani Tbakhi, Belay Negash Tefera, Arash Tehrani-Banihashemi, Habtamu Molla Tesfaw, Rekha Thapar, Aravind Thavamani, Seyed Abolfazl Tohidast, Daniel Nigusse Tollosa, Maria Elena Tosti, Marcos Roberto Tovani-Palone, Eugenio Traini, Mai Thi Ngoc Tran, Indang Trihandini, Biruk Shalmeno Tusa, Irfan Ullah, Marco Vacante, Sahel Valadan Tahbaz, Pascual R. Valdez, Shoban Babu Varthya, Bay Vo, Yasir Waheed, Adisu Birhanu Weldesenbet, Melat Woldemariam, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Mehdi Yaseri, Yigizie Yeshaw, Vahit Yigit, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Chuanhua Yu, Ismaeel Yunusa, Mazyar Zahir, Leila Zaki, Mohammad Zamani, Maryam Zamanian, Mikhail Sergeevich Zastrozhin, Theo Vos, John W. Ward, M. Ashworth Dirac

Summary: This study estimated the global, regional, and national prevalence of HBV, as well as mortality and DALYs due to HBV in 2019. It found a decline in HBV infection rates in different age groups, but an increase in HBV-related deaths. Many countries have reached the target for HBV infection rates in children, but targets for reducing deaths and cases have not been met, and progress needs to be accelerated to achieve the 2030 goals.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Multidisciplinary Sciences

Vitamin D deficiency and associated factors among antenatal care attending pregnant women in Sodo town, South Ethiopia: A facility-based cross-sectional study

Dibora Teferi Haile, Takele Tadesse Damote, Fikadu Elias Sadamo, Zeleke Geto Demissie, Samson Kastro Dake

Summary: Vitamin D deficiency is prevalent among pregnant women, with higher rates observed in obese women and those who do not consume eggs. However, exposure to mid-day sunlight is protective against Vitamin D deficiency.

PLOS ONE (2022)

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Article Cell Biology

Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, Joao Pedro de Magalhaes, Adam R. Renslo, Alexandra Stolzing, Amit Sharma

Summary: Senescent cells can spread the senescent phenotype to other cells through secretory factors. Previous characterizations of paracrine senescence were unreliable due to mixed populations of senescent and non-senescent cells. This study isolates senescent cells using DPP4 as a surface marker and enriches the percentage of paracrine senescence. The researchers observe ferroptosis dysregulation and ferrous iron accumulation in both primary and paracrine senescent cells and identify a potential senolytic approach.

CELL REPORTS (2023)

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Article Oncology

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories A Systematic Analysis for the Global Burden of Disease Study 2019

Amanda Ramos da Cunha, Kelly Compton, Rixing Xu, Rashmi Mishra, Mark Thomas Drangsholt, Jose Leopoldo Ferreira Antunes, Alexander R. Kerr, Alistair R. Acheson, Dan Lu, Lindsey E. Wallace, Jonathan M. Kocarnik, Weijia Fu, Frances E. Dean, Alyssa Pennini, Hannah Jacqueline Henrikson, Tahiya Alam, Emad Ababneh, Sherief Abd-Elsalam, Meriem Abdoun, Hassan Abidi, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Tigist Demssew Adane, Isaac Yeboah Addo, Aqeel Ahmad, Sajjad Ahmad, Tarik Ahmed Rashid, Maxwell Akonde, Hanadi Al Hamad, Fares Alahdab, Yousef Alimohamadi, Vahid Alipour, Sadeq Ali Al-Maweri, Ubai Alsharif, Alireza Ansari-Moghaddam, Sumadi Lukman Anwar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y. Aravkin, Raphael Taiwo Aruleba, Malke Asaad, Tahira Ashraf, Seyyed Shamsadin Athari, Sameh Attia, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Muhammad Badar, Nayereh Baghcheghi, Maciej Banach, Mainak Bardhan, Hiba Jawdat Barqawi, Nasir Z. Bashir, Azadeh Bashiri, Habib Benzian, Eduardo Bernabe, Devidas S. Bhagat, Vijayalakshmi S. Bhojaraja, Tone Bjorge, Souad Bouaoud, Dejana Braithwaite, Nikolay Ivanovich Briko, Daniela Calina, Giulia Carreras, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Akhilanand Chaurasia, Meng Xuan Chen, William C. S. Cho, Dinh-Toi Chu, Isaac Sunday Chukwu, Eunice Chung, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Reza Darvishi Cheshmeh Soltani, Aso Mohammad Darwesh, Sisay Abebe Debela, Meseret Derbew Molla, Fikadu Nugusu Dessalegn, Mostafa Dianati-Nasab, Lankamo Ena Digesa, Shilpi Gupta Dixit, Abhinav Dixit, Shirin Djalalinia, Iman El Sayed, Maha El Tantawi, Daniel Berhanie Enyew, Daniel Asfaw Erku, Rana Ezzeddini, Adeniyi Francis Fagbamigbe, Luca Falzone, Getahun Fetensa, Takeshi Fukumoto, Piyada Gaewkhiew, Silvano Gallus, Mesfin Gebrehiwot, Ahmad Ghashghaee, Paramjit Singh Gill, Mahaveer Golechha, Pouya Goleij, Ricardo Santiago Gomez, Giuseppe Gorini, Andre Luiz Sena Guimaraes, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Arvin Haj-Mirzaian, Esam S. Halboub, Rabih Halwani, Asif Hanif, Ninuk Hariyani, Mehdi Harorani, Hamidreza Hasani, Abbas M. Hassan, Soheil Hassanipour, Mohammed Bheser Hassen, Simon I. Hay, Khezar Hayat, Brenda Yuliana Herrera-Serna, Ramesh Holla, Nobuyuki Horita, Mehdi Hosseinzadeh, Salman Hussain, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Gaetano Isola, Abhishek Jaiswal, Chinmay T. Jani, Tahereh Javaheri, Umesh Jayarajah, Shubha Jayaram, Nitin Joseph, Vidya Kadashetti, Eswar Kandaswamy, Shama D. Karanth, Ibraheem M. Karaye, Joonas H. Kauppila, Harkiran Kaur, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Javad Khanali, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Mohammad Amin Khazeei Tabari, Min Seo Kim, Farzad Kompani, Hamid Reza Koohestani, G. Anil Kumar, Om P. Kurmi, Carlo La Vecchia, Dharmesh Kumar Lal, Ivan Landires, Savita Lasrado, Caterina Ledda, Yo Han Lee, Massimo Libra, Stephen S. Lim, Stefan Listl, Platon D. Lopukhov, Ahmad R. Mafi, Rashidul Alam Mahumud, Ahmad Azam Malik, Manu Raj Mathur, Sazan Qadir Maulud, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Tomislav Mestrovic, Reza Mirfakhraie, Awoke Misganaw, Sanjeev Misra, Prasanna Mithra, Yousef Mohammad, Mokhtar Mohammadi, Esmaeil Mohammadi, Ali H. Mokdad, Mohammad Ali Moni, Paula Moraga, Shane Douglas Morrison, Hamid Reza Mozaffari, Sumaira Mubarik, Christopher J. L. Murray, Tapas Sadasivan Nair, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Hasan Nassereldine, Zuhair S. Natto, Biswa Prakash Nayak, Serban Mircea Negru, Haruna Asura Nggada, Hasti Nouraei, Virginia Nunez-Samudio, Bogdan Oancea, Andrew T. Olagunju, Ahmed Omar Bali, Alicia Padron-Monedero, Jagadish Rao Padubidri, Anamika Pandey, Shahina Pardhan, Jay Patel, Raffaele Pezzani, Zahra Zahid Piracha, Navid Rabiee, Venkatraman Radhakrishnan, Raghu Anekal Radhakrishnan, Amir Masoud Rahmani, Vahid Rahmanian, Chythra R. Rao, Sowmya J. Rao, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Nazila Rezaei, Negar Rezaei, Nima Rezaei, Aziz Rezapour, Abanoub Riad, Thomas J. Roberts, Esperanza Romero-Rodriguez, Gholamreza Roshandel, S. Manjula, S. N. Chandan, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Mohsen Safaei, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Abdallah M. Samy, Milena M. Santric-Milicevic, Brijesh Sathian, Maheswar Satpathy, Mario Sekerija, Subramanian Senthilkumaran, Allen Seylani, Omid Shafaat, Hamid R. Shahsavari, Erfan Shamsoddin, Mequannent Melaku Sharew, Javad Sharifi-Rad, Jeevan K. Shetty, K. M. Shivakumar, Parnian Shobeiri, Seyed Afshin Shorofi, Sunil Shrestha, Sudeep K. Siddappa Malleshappa, Paramdeep Singh, Jasvinder A. Singh, Garima Singh, Dhirendra Narain Sinha, Yonatan Solomon, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Yasaman Taheri Abkenar, Iman M. Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Arulmani Thiyagarajan, Amir Tiyuri, Marcos Roberto Tovani-Palone, Bhaskaran Unnikrishnan, Bay Vo, Simona Ruxandra Volovat, Cong Wang, Ronny Westerman, Nuwan Darshana Wickramasinghe, Hong Xiao, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, Lisa M. Force, Fernando N. Hugo

Summary: Lip, oral, and pharyngeal cancers are significant contributors to the global cancer burden. This study analyzed their total and risk-attributable burden across different regions and identified disparities based on Socio-demographic Index (SDI). The findings highlight the substantial impact of tobacco and alcohol use on these types of cancers.

JAMA ONCOLOGY (2023)

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Article Clinical Neurology

Factors associated with adherence to guidelines in cancer pain management among adult patients evaluated at oncology unit, in the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Anteneh Ayelign Kibret, Haileab Fekadu Wolde, Meseret Derbew Molla, Hailu Aragie, Dagnew Getnet Adugna, Ephrem Tafesse, Endalkachew Belayneh Melese, Yilkal Belete Worku, Daniel Gashaneh Belay

Summary: This study aimed to assess factors associated with adherence to guidelines in cancer pain management among adult patients at the oncology unit of the University of Gondar Comprehensive Specialized Hospital (UoGCSH), Northwest Ethiopia. The results showed a relatively low prevalence of poor adherence to guidelines in cancer pain management among adult patients. Factors such as being unmarried, having metastasis cancer, and being in stage III or stage IV were significantly associated with poor adherence to guidelines in cancer pain management.

FRONTIERS IN PAIN RESEARCH (2022)

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Article Medicine, General & Internal

Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020

Dana Bryazka, Marissa B. Reitsma, Max G. Griswold, Kalkidan Hassen Abate, Cristiana Abbafati, Mohsen Abbasi Kangevari, Zeinab Abbasi Kangevari, Amir Abdoli, Mohammad Abdollahi, Abu Yousuf Md Abdullah, E. S. Abhilash, Eman Abu Gharbieh, Juan Manuel Acuna, Giovanni Addolorato, Oladimeji M. Adebayo, Victor Adekanmbi, Kishor Adhikari, Sangeet Adhikari, Qorinah Estiningtyas Sakilah Adnani, Saira Afzal, Wubetu Yimam Agegnehu, Manik Aggarwal, Bright Opoku Ahinkorah, Araz Ramazan Ahmad, Sajjad Ahmad, Tauseef Ahmad, Ali Ahmadi, Sepideh Ahmadi, Haroon Ahmed, Tarik Ahmed Rashid, Chisom Joyqueenet Akunna, Hanadi Al Hamad, Md Zakiul Alam, Dejene Tsegaye Alem, Kefyalew Addis Alene, Yousef Alimohamadi, Atiyeh Alizadeh, Kasim Allel, Jordi Alonso, Saba Alvand, Nelson Alvis Guzman, Firehiwot Amare, Edward Kwabena Ameyaw, Sohrab Amiri, Robert Ancuceanu, Jason A. Anderson, Catalina Liliana Andrei, Tudorel Andrei, Jalal Arabloo, Muhammad Arshad, Anton A. Artamonov, Zahra Aryan, Malke Asaad, Mulusew A. Asemahagn, Thomas Astell Burt, Seyyed Shamsadin Athari, Desta Debalkie Atnafu, Prince Atorkey, Alok Atreya, Floriane Ausloos, Marcel Ausloos, Getinet Ayano, Martin Amogre Ayanore, Olatunde O. Ayinde, Jose L. Ayuso Mateos, Sina Azadnajafabad, Melkalem Mamuye Azanaw, Mohammadreza Azangou Khyavy, Amirhossein Azari Jafari, Ahmed Y. Azzam, Ashish D. Badiye, Nasser Bagheri, Sara Bagherieh, Mohan Bairwa, Shankar M. Bakkannavar, Ravleen Kaur Bakshi, Awraris Hailu Balchut, Tilxrnighausen Null, Fabio Barra, Amadou Barrow, Pritish Baskaran, Luis Belo, Derrick A. Bennett, Isabela M. Bensenor, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Ashish Bhalla, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Krittika Bhattacharyya, Vijayalakshmi S. Bhojaraja, Bagas Suryo Bintoro, Elena A. Elena Blokhina, Belay Boda Abule Bodicha, Archith Boloor, Cristina Bosetti, Dejana Braithwaite, Hermann Brenner, Nikolay Ivanovich Briko, Andre R. Brunoni, Zahid A. Butt, Chao Cao, Yin Cao, Rosario Cardenas, Andre F. Carvalho, Marcia Carvalho, Joao Mauricio Castaldelli Maia, Giulio Castelpietra, Luis F. S. Castro de Araujo, Maria Sofia Cattaruzza, Promit Ananyo Chakraborty, Jaykaran Charan, Vijay Kumar Chattu, Akhilanand Chaurasia, Nicolas Cherbuin, Dinh Toi Chu, Nandita Chudal, Sheng Chia Chung, Chuchu Churko, Liliana G. Ciobanu, Massimo Cirillo, Rafael M. Claro, Simona Costanzo, Richard G. Cowden, Michael H. Criqui, Natalia Cruz Martins, Garland T. Culbreth, Berihun Assefa Dachew, Omid Dadras, Xiaochen Dai, Giovanni Damiani, Lalit Dandona, Rakhi Dandona, Beniam Darge Daniel, Anna Danielewicz, Jiregna Darega Gela, Kairat Davletov, Jacyra Azevedo Paiva de Araujo, Antonio Reis de Sa Junior, Sisay Abebe Debela, Azizallah Dehghan, Andreas K. Demetriades, Meseret Derbew Molla, Rupak Desai, Abebaw Alemayehu Desta, Diana Dias da Silva, Daniel Diaz, Lankamo Ena Digesa, Mengistie Diress, Milad Dodangeh, Deepa Dongarwar, Fariba Dorostkar, Haneil Larson Dsouza, Bereket Duko, Bruce B. Duncan, Kristina Edvardsson, Michael Ekholuenetale, Frank J. Elgar, Muhammed Elhadi, Mohamed A. Elmonem, Aman Yesuf Endries, Sharareh Eskandarieh, Azin Etemadimanesh, Adeniyi Francis Fagbamigbe, Ildar Ravisovich Fakhradiyev, Fatemeh Farahmand, Carla Sofia E. Sa Farinha, Andre Faro, Farshad Farzadfar, Ali Fatehizadeh, Nelsensius Klau Fauk, Valery L. Feigin, Rachel Feldman, Xiaoqi Feng, Zinabu Fentaw, Simone Ferrero, Lorenzo Ferro Desideri, Irina Filip, Florian Fischer, Joel Msafiri Francis, Richard Charles Franklin, Peter Andras Gaal, Mohamed M. Gad, Silvano Gallus, Fabio Galvano, Balasankar Ganesan, Tushar Garg, Mesfin Gebrehiwot Damtew Gebrehiwot, Teferi Gebru Gebremeskel, Mathewos Alemu Gebremichael, Tadele Regasa Gemechu, Lemma Getacher, Motuma Erena Getachew, Abera Getachew Obsa, Asmare Getie, Amir Ghaderi, Mansour Ghafourifard, Alireza Ghajar, Seyyed Hadi Ghamari, Lilian A. Ghandour, Mohammad Ghasemi Nour, Ahmad Ghashghaee, Sherief Ghozy, Franklin N. Glozah, Ekaterina Vladimirovna Glushkova, Justyna Godos, Amit Goel, Salime Goharinezhad, Mahaveer Golechha, Pouya Goleij, Mohamad Golitaleb, Felix Greaves, Michal Grivna, Giuseppe Grosso, Temesgen Worku Gudayu, Bhawna Gupta, Rajeev Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Nima Hafezi Nejad, Arvin Haj Mirzaian, Brian J. Hall, Rabih Halwani, Tiilahun Beyene Handiso, Graeme J. Hankey, Sanam Hariri, Josep Maria Haro, Ahmed Hasaballah, Hossein Hassanian Moghaddam, Simon Hay, Khezar Hayat, Golnaz Heidari, Mohammad Heidari, Delia Hendrie, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Mbuzeleni Mbuzeleni Hlongwa, Ramesh Holla, Md Mahbub Hossain, Sahadat Hossain, Seyed Kianoosh Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Guoqing Hu, Junjie Huang, Salman Hussain, Segun Emmanuel Ibitoye, Irena M. Ilic, Milena D. Ilic, Mustapha Immurana, Lalu Muhammad Irham, M. Mofizul Islam, Rakibul M. Islam, Sheikh Mohammed Shariful Islam, Hiroyasu Iso, Ramaiah Itumalla, Masao Iwagami, Roxana Jabbarinejad, Louis Jacob, Mihajlo Jakovljevic, Zahra Jamalpoor, Elham Jamshidi, Sathish Kumar Jayapal, Umesh Umesh Jayarajah, Ranil Jayawardena, Rime Jebai, Seyed Ali Jeddi, Alelign Tasew Jema, Ravi Prakash Jha, Har Ashish Jindal, Jost B. Jonas, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jurisson, Ali Kabir, Robel Hussen Kabthymer, Bhushan Dattatray Kamble, Himal Kandel, Girum Gebremeskel Kanno, Neeti Kapoor, Ibraheem M. Karaye, Salah Eddin Karimi, Bekalu Getnet Kassa, Rimple Jeet Kaur, Gbenga A. Kayode, Mohammad Keykhaei, Himanshu Khajuria, Rovshan Khalilov, Imteyaz A. Khan, Moien Ab Khan, Hanna Kim, Jihee Kim, Min Seo Kim, Ruth W. Kimokoti, Mika Kivimaki, Vitalii Klymchuk, Ann Kristin Skrindo Knudsen, Ali Asghar Kolahi, Vladimir Andreevich Korshunov, Ai Koyanagi, Kewal Krishan, Yuvaraj Krishnamoorthy, G. Anil Kumar, Nithin Kumar, Ben Lacey, Tea Lallukka, Savita Lasrado, Jerrald Lau, Sang Woong Lee, Wei Chen Lee, Yo Han Lee, Lee Ling Lim, Stephen S. Lim, Stany W. Lobo, Platon D. Lopukhov, Stefan Lorkowski, Rafael Lozano, Giancarlo Lucchetti, Farzan Madadizadeh, Soleiman Mahjoub, Ata Mahmoodpoor, Rashidul Alam Mahumud, Alaa Makki, Mohammad Reza Malekpour, Narayana Manjunatha, Borhan Mansouri, Mohammad Ali Mansournia, Jose Martinez Raga, Francisco A. Martinez Villa, Richard Matzopoulos, Pallab K. Maulik, Mahsa Mayeli, John J. McGrath, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Ritesh G. Menezes, Gert B. M. Mensink, Alexios Fotios A. Mentis, Atte Meretoja, Bedasa Taye Merga, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Ana Carolina Micheletti Gomide Nogueira de Sa, Ted R. Miller, Gk Mini, Andreea Mirica, Antonio Mirijello, Seyyedmohammadsadeq Mirmoeeni, Erkin M. Mirrakhimov, Sanjeev Misra, Babak Moazen, Maryam Mobarakabadi, Marcello Moccia, Yousef Mohammad, Esmaeil Mohammadi, Abdollah Mohammadian Hafshejani, Teroj Abdulrahman Mohammed, Nagabhishek Moka, Ali H. Mokdad, Sara Momtazmanesh, Yousef Moradi, Ebrahim Mostafavi, Sumaira Mubarik, Erin C. Mullany, Beemnet Tekabe Mulugeta, Efren Murillo Zamora, Christopher J. L. Murray, Julius C. Mwita, Mohsen Naghavi, Mukhammad David Naimzada, Vinay Nangia, Biswa Prakash Nayak, Ionut Negoi, Ruxandra Irina Negoi, Seyed Aria Nejadghaderi, Samata Nepal, Sudan Prasad Prasad Neupane, Sandhya Neupane Kandel, Yeshambel T. Nigatu, Ali Nowroozi, Khan M. Nuruzzaman, Chimezie Igwegbe Nzoputam, Kehinde O. Obamiro, Felix Akpojene Ogbo, Ayodipupo Sikiru Oguntade, Hassan Okati Aliabad, Babayemi Oluwaseun Olakunde, Glaucia Maria Moraes Oliveira, Ahmed Omar Bali, Emad Omer, Doris V. Ortega Altamirano, Adrian Otoiu, Stanislav S. Otstavnov, Bilcha Oumer, P. A. Mahesh, Alicia Padron Monedero, Raffaele Palladino, Adrian Pana, Songhomitra Panda Jonas, Ashok Pandey, Shahina Pardhan, Tarang Parekh, Eun Kee Park, Charles D. H. Parry, Fatemeh Pashazadeh Kan, Jay Patel, Siddhartha Pati, George C. Patton, Uttam Paudel, Shrikant Pawar, Amy E. Peden, Ionela Roxana Petcu, Michael R. Phillips, Marina Pinheiro, Evgenii Plotnikov, Pranil Man Singh Pradhan, Akila Prashant, Jianchao Quan, Amir Radfar, Alireza Rafiei, Pankaja Raghav Raghav, Vafa Rahimi Movaghar, Azizur Rahman, Md Mosfequr Rahman, Mosiur Rahman, Amir Masoud Rahmani, Shayan Rahmani, Chhabi Lal Ranabhat, Priyanga Ranasinghe, Chythra R. Rao, Drona Prakash Rasali, Mohammad Mahdi Rashidi, Zubair Ahmed Ratan, David Laith Rawaf, Salman Rawaf, Lal Rawal, Andre M. N. Renzaho, Negar Rezaei, Saeid Rezaei, Mohsen Rezaeian, Seyed Mohammad Riahi, Esperanza Romero Rodriguez, Gregory A. Roth, Godfrey M. Rwegerera, Basema Saddik, Erfan Sadeghi, Reihaneh Sadeghian, Umar Saeed, Farhad Saeedi, Rajesh Sagar, Amirhossein Sahebkar, Harihar Sahoo, Mohammad Ali Sahraian, Km Saif Ur Rahman, Sarvenaz Salahi, Hamideh Salimzadeh, Abdallah M. Samy, Francesco Sanmarchi, Milena M. Santric Milicevic, Yaser Sarikhani, Brijesh Sathian, Ganesh Kumar Saya, Mehdi Sayyah, Maria Ines Schmidt, Aletta Elisabeth Schutte, Michael Schwarzinger, David C. Schwebel, Abdul Aziz Seidu, Nachimuthu Senthil Kumar, SeyedAhmad SeyedAlinaghi, Allen Seylani, Feng Sha, Sarvenaz Shahin, Fariba Shahraki Sanavi, Shayan Shahrokhi, Masood Ali Shaikh, Elaheh Shaker, Murad Ziyaudinovich Shakhmardanov, Mehran Shams Beyranvand, Sara Sheikhbahaei, Rahim Ali Sheikhi, Adithi Shetty, Jeevan K. Shetty, Damtew Solomon Shiferaw, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Velizar Shivarov, Parnian Shobeiri, Roman Shrestha, Negussie Boti Sidemo, Inga Dora Sigfusdottir, Diego Augusto Santos Silva, Natacha Torres da Silva, Jasvinder A. Singh, Surjit Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, David A. Sleet, Marco Solmi, Yonatan Solomon, Suhang Song, Yimeng Song, Reed J. D. Sorensen, Sergey Soshnikov, Ireneous N. Soyiri, Dan J. Stein, Sonu Hangma Subba, Miklos Szocska, Rafael Tabares Seisdedos, Takahiro Tabuchi, Majid Taheri, Ker Kan Tan, Minale Tareke, Elvis Enowbeyang Tarkang, Gebremaryam Temesgen, Worku Animaw Temesgen, Mohamad Hani Temsah, Kavumpurathu Raman Thankappan, Rekha Thapar, Nikhil Kenny Thomas, Chalachew Tiruneh, Jovana Todorovic, Marco Torrado, Mathilde Touvier, Marcos Roberto Tovani Palone, Mai Thi Ngoc Tran, Sergi Trias Llimos, Jaya Prasad Tripathy, Alireza Vakilian, Rohollah Valizadeh, Mehdi Varmaghani, Shoban Babu Varthya, Tommi Juhani Vasankari, Theo Vos, Birhanu Wagaye, Yasir Waheed, Mandaras Tariku Walde, Cong Wang, Yanzhong Wang, Yuan Pang Wang, Ronny Westerman, Nuwan Darshana Wickramasinghe, Abate Dargie Wubetu, Suowen Xu, Kazumasa Yamagishi, Lin Yang, Gesila Endashaw E. Yesera, Arzu Yigit, Vahit Yigit, Ayenew Engida Yimaw, Dong Keon Yon, Naohiro Yonemoto, Chuanhua Yu, Siddhesh Zadey, Mazyar Zahir, Iman Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Zhi Jiang Zhang, Chenwen Zhong, Mohammad Zmaili, Yves Miel H. Zuniga, Emmanuela Gakidou, Aurea M. Madureira-Carvalho

Summary: This study examines the relationship between alcohol consumption and health risks by constructing burden-weighted dose-response relative risk curves. The findings suggest that the impact of alcohol on health risks varies depending on age and location, highlighting the need for tailored recommendations and interventions, particularly for younger individuals.

LANCET (2022)

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