Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children

Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring

(2022) Gayan Bowatte et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring

(2022) Yunyun Liu et al.   Epigenetics & Chromatin

Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

(2022) Anne-Sophie Pepin et al.   Molecular Metabolism

Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to sperm

(2022) Millissia Ben Maamar et al.   iScience

Epigenetic inheritance is gated by naïve pluripotency and Dppa2

(2022) Valentina Carlini et al.   EMBO JOURNAL

Parental Prepuberty Overweight and Offspring Lung Function

(2022) Marianne Lønnebotn et al.   Nutrients

Paternal High-Fat Diet Altered Sperm 5'tsRNA-Gly-GCC Is Associated With Enhanced Gluconeogenesis in the Offspring

(2022) Bin Wang et al.   Frontiers in Molecular Biosciences

Testicular “Inherited Metabolic Memory” of Ancestral High-Fat Diet Is Associated with Sperm sncRNA Content

(2022) Luís Crisóstomo et al.   Biomedicines

Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect

(2022) Jiacheng Liu et al.   EUROPEAN RESPIRATORY JOURNAL

Male obesity impacts DNA methylation reprogramming in sperm

(2021) Sanaz Keyhan et al.   Clinical Epigenetics

Epigenetic transgenerational inheritance, Gametogenesis and Germline Development

(2021) Millissia Ben Maamar et al.   BIOLOGY OF REPRODUCTION

Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

(2021) Simone Accordini et al.   EUROPEAN RESPIRATORY JOURNAL

Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

(2021) Barbara Hammer et al.   INTERNATIONAL JOURNAL OF OBESITY

Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

(2021) Georges Raad et al.   eLife

Ancestral smoking and developmental outcomes: a review of publications from a population birth cohort

(2021) Jean Golding et al.   BIOLOGY OF REPRODUCTION

Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action

(2021) Ali Altıntaş et al.   FASEB JOURNAL

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies

(2021) Hopin Lee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation

(2021) Hai-Yan Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Epigenetics of Male Infertility: The Role of DNA Methylation

(2021) John Charles Rotondo et al.   Frontiers in Cell and Developmental Biology

Simulated Wildfire Smoke Significantly Alters Sperm DNA Methylation Patterns in a Murine Model

(2021) Adam Schuller et al.   Toxics

Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma

(2021) Gro Tjalvin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

(2021) Juan Pablo López-Cervantes et al.   International Journal of Environmental Research and Public Health

Preconception helminth infection alters offspring microbiota and immune subsets in a mouse model

(2020) Donald D. Nyangahu et al.   PARASITE IMMUNOLOGY

Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior

(2020) Shiraz Tyebji et al.   Cell Reports

Parental occupational exposure pre- and post-conception and development of asthma in offspring

(2020) Kathrine Pape et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Paternal high-fat diet and exercise regulate sperm miRNA and histone methylation to modify placental inflammation, nutrient transporter mRNA expression and fetal weight in a sex-dependent manner

(2020) Kate G. Claycombe-Larson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study

(2020) Gerd Toril Mørkve Knudsen et al.   PLoS One

Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever

(2020) Ingrid Nordeide Kuiper et al.   International Journal of Environmental Research and Public Health

NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure

(2020) Patrick J. Murphy et al.   PLoS Genetics

High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

(2020) Sharvari S. Deshpande et al.   Clinical Epigenetics

Impact of Parental Exposure on Offspring Health in Humans

(2020) Ali Jawaid et al.   TRENDS IN GENETICS

Agreement of offspring-reported parental smoking status: the RHINESSA generation study

(2019) Kathrine Pape et al.   BMC PUBLIC HEALTH

Offspring reports on parental place of upbringing

(2019) Signe Timm et al.   EPIDEMIOLOGY

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

(2019) Deven M. Patel et al.   INTERNATIONAL JOURNAL OF CANCER

Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs

(2019) Gitalee Sarker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling of epididymal small non‐protein‐coding RNA s

(2019) B. Nixon et al.   Andrology

Investigating Possible Trans/Intergenerational Associations With Obesity in Young Adults Using an Exposome Approach

(2019) Jean Golding et al.   Frontiers in Genetics

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

(2019) Matthew G. Darby et al.   Science Advances

Mediational E-values

(2019) Louisa H. Smith et al.   EPIDEMIOLOGY

Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?

(2019) Ane Johannessen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sex-specific programming effects of parental obesity in pre-implantation embryonic development

(2019) Kathrin Hedegger et al.   INTERNATIONAL JOURNAL OF OBESITY

Control of noncoding RNA production and histone levels by a 5′ tRNA fragment

(2019) Ana Boskovic et al.   GENES & DEVELOPMENT

Human sperm displays rapid responses to diet

(2019) Daniel Nätt et al.   PLOS BIOLOGY

Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation

(2018) Vickie R. Walker et al.   ENVIRONMENT INTERNATIONAL

A three-generation study on the association of tobacco smoking with asthma

(2018) Simone Accordini et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Childhood asthma and smoking exposures before conception-A three-generational cohort study

(2018) Lennart Bråbäck et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

(2018) Canan Kuscu et al.   RNA

Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses—an animal study

(2018) Katharina Bomans et al.   Clinical Epigenetics

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

(2018) David A. Dickson et al.   Translational Psychiatry

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

(2018) Dinh S Bui et al.   Lancet Respiratory Medicine

miR-155 and miR-122 Expression of Spermatozoa in Obese Subjects

(2018) Paulina López et al.   Frontiers in Genetics

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Commentary: Tobacco smoking and asthma: multigenerational effects, epigenetics and multilevel causal mediation analysis

(2018) Onyebuchi A Arah   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Trends in smoking initiation in Europe over 40 years: A retrospective cohort study

(2018) Alessandro Marcon et al.   PLoS One

Agreement in reporting of asthma by parents or offspring – the RHINESSA generation study

(2018) Ingrid N. Kuiper et al.   BMC Pulmonary Medicine

Paternal Exercise Improves Glucose Metabolism in Adult Offspring

(2018) Kristin I. Stanford et al.   DIABETES

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

(2018) Sarah Wyck et al.   Epigenetics & Chromatin

Gene expression and epigenetic aberrations in F1-placentas fathered by obese males

(2017) Megan Mitchell et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Validation of maternal reported pregnancy and birth characteristics against the Medical Birth Registry of Norway

(2017) Svein Magne Skulstad et al.   PLoS One

Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa

(2017) Kate Hutcheon et al.   RNA Biology

Long non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity

(2017) Tian An et al.   Oncotarget

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b

(2017) Jingbo Dai et al.   Scientific Reports

Mediation Analysis: A Practitioner's Guide

(2016) Tyler J. VanderWeele   Annual Review of Public Health

Is the Epididymis a Series of Organs Placed Side By Side?

(2016) R. F. Domeniconi et al.   BIOLOGY OF REPRODUCTION

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Small non-coding RNAs and their associated proteins in spermatogenesis

(2016) Ling-Feng Luo et al.   GENE

The human epididymis: its function in sperm maturation

(2016) Robert Sullivan et al.   HUMAN REPRODUCTION UPDATE

Fat eggs shape offspring health

(2016) Erica D Watson et al.   NATURE GENETICS

Specification and epigenetic programming of the human germ line

(2016) Walfred W. C. Tang et al.   NATURE REVIEWS GENETICS

Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years

(2016) Julia Dratva et al.   PLoS One

Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study

(2016) Adelheid Soubry et al.   Clinical Epigenetics

Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children

(2016) Kiwako Yamamoto-Hanada et al.   ALLERGOLOGY INTERNATIONAL

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

(2016) Jennifer E. Cropley et al.   Molecular Metabolism

Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring’s Sperm

(2016) Tod Fullston et al.   PLoS One

Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring

(2015) Nicole O. McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

DNA Demethylation Dynamics in the Human Prenatal Germline

(2015) Sofia Gkountela et al.   CELL

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression

(2015) Minoru Terashima et al.   Epigenetics

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking

(2015) Catherine Metzler-Guillemain et al.   Systems Biology in Reproductive Medicine

Grandmother's smoking when pregnant with the mother and asthma in the grandchild: the Norwegian Mother and Child Cohort Study

(2015) M. C. Magnus et al.   THORAX

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

(2014) Adam J. Watkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

(2014) Adelheid Soubry et al.   BIOESSAYS

Prepubertal start of father’s smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses

(2014) Kate Northstone et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Interaction between asthma and smoking increases the risk of adult airway obstruction

(2014) Marianne Aanerud et al.   EUROPEAN RESPIRATORY JOURNAL

Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research

(2014) Marcus Pembrey et al.   JOURNAL OF MEDICAL GENETICS

DNA methylation dynamics of the human preimplantation embryo

(2014) Zachary D. Smith et al.   NATURE

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Is the Growth of the Fetus of a Non-Smoking Mother Influenced by the Smoking of Either Grandmother while Pregnant?

(2014) Laura L. Miller et al.   PLoS One

DNA methylation signatures link prenatal famine exposure to growth and metabolism

(2014) Elmar W. Tobi et al.   Nature Communications

Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters

(2014) M. F. Hamad et al.   Andrology

Perinatal nicotine-induced transgenerational asthma

(2013) Virender K. Rehan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Perinatal nicotine exposure induces asthma in second generation offspring

(2012) Virender K Rehan et al.   BMC Medicine

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

(2012) Emma L. Marczylo et al.   Epigenetics

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms

(2012) Maria Rosa Garcia-Silva et al.   Genes

Oral contraceptive pill use before pregnancy and respiratory outcomes in early childhood

(2011) Dana B. Hancock et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Developmental plasticity and developmental origins of non-communicable disease: Theoretical considerations and epigenetic mechanisms

(2011) Mark Hanson et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Forced vital capacity, airway obstruction and survival in a general population sample from the USA

(2010) P. G. J. Burney et al.   THORAX

Developmental origins of metabolic disease: life course and intergenerational perspectives

(2010) Keith M. Godfrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Early life origins of chronic obstructive pulmonary disease

(2009) C Svanes et al.   THORAX

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA