Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research

Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren

(2014) Lars Bygren et al.   BMC GENETICS

Prepubertal start of father’s smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses

(2014) Kate Northstone et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

(2014) A. L. Teh et al.   GENOME RESEARCH

Cohort Profile: UK Millennium Cohort Study (MCS)

(2014) R. Connelly et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Origins and functional evolution of Y chromosomes across mammals

(2014) Diego Cortez et al.   NATURE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Is the Growth of the Fetus of a Non-Smoking Mother Influenced by the Smoking of Either Grandmother while Pregnant?

(2014) Laura L. Miller et al.   PLoS One

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

(2014) Yanchang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring

(2014) John J. Bromfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs in hematological diseases: principles, challenges, and perspectives

(2013) S. Grasedieck et al.   BLOOD

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Do Grandmaternal Smoking Patterns Influence the Etiology of Childhood Asthma?

(2013) Laura L. Miller et al.   CHEST

Association of maternal and nutrient supply line factors with DNA methylation at the imprintedIGF2/H19locus in multiple tissues of newborn twins

(2013) Yuk Jing Loke et al.   Epigenetics

The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype

(2013) Chau-To Kwok et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Transgenerational developmental programming

(2013) Catherine E. Aiken et al.   HUMAN REPRODUCTION UPDATE

DNA methylation establishment during oocyte growth: mechanisms and significance

(2013) Shin-Ichi Tomizawa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Childhood and adulthood socio-economic position and hypertensive disorders in pregnancy: the Uppsala Birth Cohort Multigenerational Study

(2013) Amy Heshmati et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Hypomethylation marks enhancers within transposable elements

(2013) Zohar Mukamel et al.   NATURE GENETICS

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Stability, delivery and functions of human sperm RNAs at fertilization

(2013) Edward Sendler et al.   NUCLEIC ACIDS RESEARCH

Environmentally Induced Transgenerational Epigenetic Reprogramming of Primordial Germ Cells and the Subsequent Germ Line

(2013) Michael K. Skinner et al.   PLoS One

The importance of the intrauterine environment in shaping the human neonatal epigenome

(2013) Boris Novakovic et al.   Epigenomics

Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics

(2013) Anne Gabory et al.   Biology of Sex Differences

Effects of Stress Across Generations: Why Sex Matters

(2012) Frances A. Champagne   BIOLOGICAL PSYCHIATRY

Chronic Social Instability Induces Anxiety and Defective Social Interactions Across Generations

(2012) Lorena Saavedra-Rodríguez et al.   BIOLOGICAL PSYCHIATRY

Developmental origins of non-communicable disease: Implications for research and public health

(2012) Robert Barouki et al.   Environmental Health

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

(2012) Emma L. Marczylo et al.   Epigenetics

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial

(2012) Wendy N. Cooper et al.   FASEB JOURNAL

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

(2012) H. Beyan et al.   GENOME RESEARCH

Cohort Profile: The Born in Bradford multi-ethnic family cohort study

(2012) J. Wright et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

(2012) Andy Boyd et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

(2012) S. Seisenberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Differentially Methylated Regions of Imprinted Genes in Prenatal, Perinatal and Postnatal Human Tissues

(2012) Susan K. Murphy et al.   PLoS One

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

(2011) Megan P. Hitchins et al.   CANCER CELL

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Methylation variation atIGF2differentially methylated regions and maternal folic acid use before and during pregnancy

(2011) Cathrine Hoyo et al.   Epigenetics

Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood

(2011) Y Ba et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

(2011) Sébastien A Smallwood et al.   NATURE GENETICS

Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation

(2011) Jason Gertz et al.   PLoS Genetics

Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

(2010) George Davey Smith   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Long-lasting and transgenerational effects of an environmental enrichment on memory formation

(2010) Junko A. Arai et al.   BRAIN RESEARCH BULLETIN

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

(2010) Miina Ollikainen et al.   HUMAN MOLECULAR GENETICS

Ancestral paternal genotype controls body weight and food intake for multiple generations

(2010) Soha N. Yazbek et al.   HUMAN MOLECULAR GENETICS

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort

(2010) C. Macdonald-Wallis et al.   OSTEOPOROSIS INTERNATIONAL

Male-line transgenerational responses in humans

(2010) Marcus E. Pembrey   Human Fertility

Bigger babies born to women survivors of the 1959–1961 Chinese famine: a puzzle due to survival selection?

(2010) C. Huang et al.   Journal of Developmental Origins of Health and Disease

Exposure of Mouse Embryos to Ethanol During Preimplantation Development: Effect on DNA Methylation in the H19 Imprinting Control Region1

(2009) Philip C. Haycock et al.   BIOLOGY OF REPRODUCTION

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

The human sperm epigenome and its potential role in embryonic development

(2009) D. T. Carrell et al.   MOLECULAR HUMAN REPRODUCTION

Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child

(2009) Régine P. Steegers-Theunissen et al.   PLoS One

Superovulation in mice alters the methylation pattern of imprinted genes in the sperm of the offspring

(2009) Christelle Stouder et al.   REPRODUCTIVE TOXICOLOGY

Nutritional Supplementation in Early Childhood, Schooling, and Intellectual Functioning in Adulthood

(2008) Aryeh D. Stein et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans

(2008) Rosa M. Alcazar et al.   GENETICS

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of parental and grandparental childhood social disadvantage to circulatory disease diagnosis in young Swedish men

(2008) Bitte Modin et al.   SOCIAL SCIENCE & MEDICINE