Epigenetic inheritance is gated by naïve pluripotency and Dppa2

Epigenetic editing: Dissecting chromatin function in context

(2021) Cristina Policarpi et al.   BIOESSAYS

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

(2021) James K. Nuñez et al.   CELL

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

(2020) Sandra Catania et al.   CELL

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

(2020) Spencer A. Haws et al.   MOLECULAR CELL

Chromatin replication and epigenetic cell memory

(2020) Kathleen R. Stewart-Morgan et al.   NATURE CELL BIOLOGY

Epigenetic regulator function through mouse gastrulation

(2020) Stefanie Grosswendt et al.   NATURE

Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development

(2020) Kristjan H. Gretarsson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment

(2020) Mélanie A. Eckersley-Maslin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic gene silencing by heterochromatin primes fungal resistance

(2020) Sito Torres-Garcia et al.   NATURE

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

(2020) Dounia Djeghloul et al.   Nature Communications

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

(2019) Michael Batie et al.   SCIENCE

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations

(2019) Lea Duempelmann et al.   MOLECULAR CELL

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

(2019) Henriette O’Geen et al.   Epigenetics & Chromatin

Advances in epigenetics link genetics to the environment and disease

(2019) Giacomo Cavalli et al.   NATURE

Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing

(2019) Hagar F. Moussa et al.   Nature Communications

Metastable epialleles and their contribution to epigenetic inheritance in mammals

(2019) Tessa M. Bertozzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Xist RNA in action: Past, present, and future

(2019) Agnese Loda et al.   PLoS Genetics

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency

(2019) Katy McLaughlin et al.   Cell Reports

A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

(2018) Christian Pflueger et al.   GENOME RESEARCH

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

(2018) Andrew P. Feinberg   NEW ENGLAND JOURNAL OF MEDICINE

The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species

(2018) Chutian Ge et al.   SCIENCE

Chromatin domains rich in inheritance

(2018) Danny Reinberg et al.   SCIENCE

Epigenetic control of variation and stochasticity in metabolic disease

(2018) Ilaria Panzeri et al.   Molecular Metabolism

Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance

(2018) Anastasiya Kazachenka et al.   CELL

The Implication of Early Chromatin Changes in X Chromosome Inactivation

(2018) Jan Jakub Żylicz et al.   CELL

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

(2018) Jamie A. Hackett et al.   Nature Communications

The Epigenetic Paradox of Pluripotent ES Cells

(2017) Nicola Festuccia et al.   JOURNAL OF MOLECULAR BIOLOGY

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

(2017) Filippo Ciabrelli et al.   NATURE GENETICS

The interplay of epigenetic marks during stem cell differentiation and development

(2017) Yaser Atlasi et al.   NATURE REVIEWS GENETICS

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

(2017) Maud Borensztein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct phases of Polycomb silencing to hold epigenetic memory of cold inArabidopsis

(2017) Hongchun Yang et al.   SCIENCE

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

DNA replication–coupled histone modification maintains Polycomb gene silencing in plants

(2017) Danhua Jiang et al.   SCIENCE

Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

(2017) Emily A. Saunderson et al.   Nature Communications

Rapid and reversible epigenome editing by endogenous chromatin regulators

(2017) Simon M. G. Braun et al.   Nature Communications

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

(2017) Maud Borensztein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

(2016) Angelo Amabile et al.   CELL

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Dynamics of epigenetic regulation at the single-cell level

(2016) L. Bintu et al.   SCIENCE

Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus

(2015) D. F. Simola et al.   SCIENCE

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained

(2015) Goran Kungulovski et al.   Epigenetics & Chromatin

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Regulatory Principles of Pluripotency: From the Ground State Up

(2014) Jamie A. Hackett et al.   Cell Stem Cell

The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

(2014) Edda G. Schulz et al.   Cell Stem Cell

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Naive pluripotency is associated with global DNA hypomethylation

(2013) Harry G Leitch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics and Memory of Heterochromatin in Living Cells

(2012) Nathaniel A. Hathaway et al.   CELL

DNA methylation dynamics during the mammalian life cycle

(2012) J. A. Hackett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

(2012) Simon Quenneville et al.   Cell Reports

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell