Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons

SNT: a unifying toolbox for quantification of neuronal anatomy

(2021) Cameron Arshadi et al.   NATURE METHODS

Correction to ‘The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets’

(2021) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Cortical Interneuron Development: a role for small Rho GTPases

(2021) Zouzana Kounoupa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathies

(2021) Marcello Scala et al.   Cells

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

(2020) Cheng-Hsin Liu et al.   eLife

NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin

(2020) Lianne C Davis et al.   EMBO JOURNAL

TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos

(2020) Chenxi Guo et al.   JOURNAL OF CELL SCIENCE

Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

(2020) Raffaella De Pace et al.   Cell Reports

Anterograde Axonal Transport in Neuronal Homeostasis and Disease

(2020) Laurent Guillaud et al.   Frontiers in Molecular Neuroscience

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

(2020) Helen Chen et al.   JCI Insight

Calcium signalling: a key regulator of neuronal migration

(2019) Shin-ichiro Horigane et al.   JOURNAL OF BIOCHEMISTRY

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis

(2019) Abeer F. Alharbi et al.   Frontiers in Cell and Developmental Biology

Two-pore channels and disease

(2018) Sandip Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders

(2018) Olivier Nicole et al.   MOLECULAR PSYCHIATRY

mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2

(2018) Oluseye A. Ogunbayo et al.   Science Signaling

Mechanisms of lysosomal positioning and movement

(2018) Birol Cabukusta et al.   TRAFFIC

A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence

(2018) Sira A. Franchi et al.   Frontiers in Cellular Neuroscience

p27 Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability

(2018) Giovanni Morelli et al.   Cell Reports

mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2

(2018) Oluseye A. Ogunbayo et al.   Science Signaling

Development and Functional Diversification of Cortical Interneurons

(2018) Lynette Lim et al.   NEURON

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling

(2018) William J. Foster et al.   Science Signaling

Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex

(2018) Katerina Kalemaki et al.   Frontiers in Neural Circuits

Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics

(2017) Max Schelski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes

(2016) Natalia Zaldua et al.   FEBS Journal

Muscle dysfunction caused by loss ofMagel2in a mouse model of Prader-Willi and Schaaf-Yang syndromes

(2016) Ain A. Kamaludin et al.   HUMAN MOLECULAR GENETICS

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons

(2016) Sylvia Neumann et al.   TRAFFIC

Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons

(2016) Sira A. Franchi et al.   Frontiers in Cellular Neuroscience

The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration

(2016) A E Hall et al.   Cell Death & Disease

Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology

(2016) Claire Shuk-Kwan Lee et al.   Scientific Reports

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders

(2016) Erika G. Lin-Hendel et al.   Cell Reports

Two-pore channels at the intersection of endolysosomal membrane traffic

(2015) Jonathan S. Marchant et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

(2015) Hamid Meziane et al.   BIOLOGICAL PSYCHIATRY

A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells

(2015) Antony Galione   CELL CALCIUM

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks

(2015) Roberta Pennucci et al.   CEREBRAL CORTEX

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca2+ signaling during myogenesis in intact zebrafish

(2015) Jeffrey J. Kelu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems

(2015) Zhong L. Hua et al.   Neural Development

Genetic variants in long non-coding RNA MIAT contribute to risk of paranoid schizophrenia in a Chinese Han population

(2015) Shu-Quan Rao et al.   SCHIZOPHRENIA RESEARCH

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex

(2015) Elise Peyre et al.   Frontiers in Cellular Neuroscience

Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1

(2015) Patricia P. Garcez et al.   Nature Communications

Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data

(2015) Camille D. A. Terfve et al.   Nature Communications

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Rac-GTPases Regulate Microtubule Stability and Axon Growth of Cortical GABAergic Interneurons

(2014) Simona Tivodar et al.   CEREBRAL CORTEX

miRNAs are Essential for the Survival and Maturation of Cortical Interneurons

(2014) Sebnem N. Tuncdemir et al.   CEREBRAL CORTEX

Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension

(2014) Jeffrey van Haren et al.   CURRENT BIOLOGY

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

PSFj: know your fluorescence microscope

(2014) Patrick Theer et al.   NATURE METHODS

Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons

(2014) Niraj Trivedi et al.   Neural Development

Computational Identification and Experimental Validation of MicroRNAs Binding to the Fragile X Syndrome Gene Fmr1

(2014) Xi Gong et al.   NEUROCHEMICAL RESEARCH

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAX6 Downregulates miR-124 Expression to Promote Cell Migration During Embryonic Stem Cell Differentiation

(2014) Jing Fang et al.   STEM CELLS AND DEVELOPMENT

Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons

(2014) Ivan de Curtis   Frontiers in Cellular Neuroscience

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization

(2013) Chih Lee et al.   BIOTECHNIQUES

Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment

(2013) Julieta Aprea et al.   EMBO JOURNAL

Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons

(2013) Maurice Meseke et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Calcium Release-Dependent Actin Flow in the Leading Process Mediates Axophilic Migration

(2013) B. I. Hutchins et al.   JOURNAL OF NEUROSCIENCE

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

(2013) G Barry et al.   MOLECULAR PSYCHIATRY

Two Pore Channel 2 Differentially Modulates Neural Differentiation of Mouse Embryonic Stem Cells

(2013) Zhe-Hao Zhang et al.   PLoS One

Rac1 and Rac3 GTPases Control Synergistically the Development of Cortical and Hippocampal GABAergic Interneurons

(2012) Valentina Vaghi et al.   CEREBRAL CORTEX

The role of small GTPases in neuronal morphogenesis and polarity

(2012) Christian Gonzalez-Billault et al.   Cytoskeleton

p27Kip1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration

(2012) Juliette D. Godin et al.   DEVELOPMENTAL CELL

Reelin promotes microtubule dynamics in processes of developing neurons

(2012) Maurice Meseke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

(2012) Ryota Shinohara et al.   NATURE NEUROSCIENCE

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Dynamics of the leading process, nucleus, and Golgi apparatus of migrating cortical interneurons in living mouse embryos

(2012) M. Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors

(2012) A. G. Hendricks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration

(2012) Tao Yang et al.   Cell Reports

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration

(2011) Siau Bai et al.   BMC BIOLOGY

Rac1-Dependent Cell Cycle Exit of MGE Precursors and GABAergic Interneuron Migration to the Cortex

(2011) Marina Vidaki et al.   CEREBRAL CORTEX

MEG3 imprinted gene contribution in tumorigenesis

(2011) Leonidas Benetatos et al.   INTERNATIONAL JOURNAL OF CANCER

Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport

(2011) Takao Nakata et al.   JOURNAL OF CELL BIOLOGY

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

(2011) Aiqun Li et al.   NATURE CELL BIOLOGY

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

Neuronal migration mechanisms in development and disease

(2010) Manuel Valiente et al.   CURRENT OPINION IN NEUROBIOLOGY

Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum

(2010) B. Ian Hutchins et al.   Developmental Neurobiology

Actomyosin Contraction at the Cell Rear Drives Nuclear Translocation in Migrating Cortical Interneurons

(2010) F. J. Martini et al.   JOURNAL OF NEUROSCIENCE

Rac1 Regulates Neuronal Polarization through the WAVE Complex

(2010) S. Tahirovic et al.   JOURNAL OF NEUROSCIENCE

3D reconstruction of histological sections: Application to mammary gland tissue

(2010) Ignacio Arganda-Carreras et al.   MICROSCOPY RESEARCH AND TECHNIQUE

MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

(2010) Carolina Montenegro-Venegas et al.   MOLECULAR BIOLOGY OF THE CELL

Guiding Neuronal Cell Migrations

(2010) O. Marin et al.   Cold Spring Harbor Perspectives in Biology

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

(2009) D. Pandey et al.   BLOOD

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Essential role of Rac1 and Rac3 GTPases in neuronal development

(2009) Sara Corbetta et al.   FASEB JOURNAL

An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles

(2009) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling

(2009) A. Hajdo-Milasinovic et al.   JOURNAL OF CELL SCIENCE

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

(2009) Andrée Gauthier-Fisher et al.   NATURE NEUROSCIENCE

Myosin II Motors and F-Actin Dynamics Drive the Coordinated Movement of the Centrosome and Soma during CNS Glial-Guided Neuronal Migration

(2009) David J. Solecki et al.   NEURON

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone

(2008) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function

(2008) Sara Mostafavi et al.   GENOME BIOLOGY