Article
Immunology
Rowayna Shouib, Gary Eitzen
Summary: Airway epithelial cells can respond to pathogens and stimulants through cytokine and chemokine secretion, but excessive secretion can cause chronic inflammation and pulmonary disorders. We identified Cdc42 as an important signaling molecule that regulates cytokine production and release. Inhibiting or silencing Cdc42 affected the gene expression and secretion of specific cytokines, particularly IL-8 trafficking and secretion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Purnati Khuntia, Simran Rawal, Rituraj Marwaha, Tamal Das
Summary: The Golgi apparatus moves from an apical position to a basal position during epithelial cell migration, driven by actin cytoskeleton instead of microtubules. The interaction between Golgi and actin is mediated by actin projections, which is critical for cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Shao-Chih Chiu, Yun-Ru Jaoying Huang, Tong-You Wade Wei, Jo-Mei Maureen Chen, Yi-Chun Kuo, Yu-Ting Jenny Huang, Yu-Ting Amber Liao, Chang-Tze Ricky Yu
Summary: The PRMT5-HURP-acetyl-tubulin axis plays a crucial role in controlling Golgi apparatus repositioning and cell migration, with HURP 122F and acetyl-tubulin alterations affecting cell polarity and migration capability.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Ana I. Seixas, Miguel R. G. Morais, Cord Brakebusch, Joao B. Relvas
Summary: Myelin plays a vital role in improving axonal conduction velocity and is essential for nerve development and regeneration. The process of myelin sheath formation in peripheral nerves is not yet fully understood, but it has been found that RhoA is involved in promoting the initiation of myelination and regulating myelin growth at different stages of peripheral myelination. RhoA acts on actin filament turnover, actomyosin contractility, and cortical actin-membrane attachments in Schwann cells, which in turn regulate axon-Schwann cell interaction/adhesion and myelin growth. This study highlights the importance of RhoA in controlling Schwann cell state transitions for proper myelination of peripheral nerves.
PROGRESS IN NEUROBIOLOGY
(2023)
Review
Cell Biology
Shubham Kumar Rai, Divya Singh, Pranita P. P. Sarangi
Summary: RhoG, a member of the Rho family of small GTPases, plays a central role in regulating immune cell functions. Recent research has shown that alterations in RhoG-specific signaling can lead to various diseases. This review highlights the cellular functions of RhoG, interconnections with different signaling pathways, and the potential importance of targeting RhoG in treating pathological conditions.
INFLAMMATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Jianyang Liu, Yan Huang, Ting Li, Zheng Jiang, Liuwang Zeng, Zhiping Hu
Summary: The Golgi apparatus plays a crucial role in cellular homeostasis and is linked to various diseases. Mutations in genes encoding Golgi resident proteins can lead to diseases, typically involving defects in membrane trafficking, protein mislocalization, and impaired glycosylation. Detection of Golgi resident proteins in human serum samples may serve as a diagnostic tool, while the central role of Golgi apparatus in membrane trafficking pathways presents potential targets for disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Chih-Cheng Chen, Chia-Chen Hsu, Sung-Lin Chen, Po-Han Lin, Ju-Pei Chen, Yi-Ru Pan, Cih-En Huang, Ying-Ju Chen, Yi-Yang Chen, Yu-Ying Wu, Muh-Hwa Yang
Summary: The BET inhibitor JQ1 abrogates amoeboid movement of DLBCL cells through restrained RAS signaling and MYC-mediated suppression of GTP-RhoA activity, while also increasing IQGAP3 expression, impacting the prognosis of specific DLBCL patients. Inhibitors targeting both BET and RAS activities effectively suppress DLBCL dissemination in vivo, suggesting their potential synergistic therapeutic effect for specific DLBCL subtypes.
Article
Oncology
Geoffrey O. Nyabuto, John P. Wilson, Samantha A. Heilman, Ryan C. Kalb, Jonathan P. Kopacz, Ankita V. Abnave, Deborah J. Vestal
Summary: The study aimed to investigate the mechanism of breast cancer cell migration and found that the GBP-2 protein can inhibit this process. Examination of GBP-2 expression in different cell lines revealed an inverse correlation with tumor aggressiveness/metastasis.
Review
Cell Biology
Akihiko Nakano
Summary: The structure of the Golgi apparatus varies among different species, but its functions remain conserved. In addition to the core layers of cisternae, the Golgi is accompanied by neighboring compartments on its cis and trans sides. High-resolution live imaging has revealed striking similarities in the behaviors of these compartments, indicating the presence of conserved mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ina Schaefer, Juliane Bauch, David Wegrzyn, Lars Roll, Simon van Leeuwen, Annika Jarocki, Andreas Faissner
Summary: This study investigates the impact of the guanine nucleotide exchange factor Vav3 on the migration behavior of oligodendrocyte precursor cells (OPCs). The results show that Vav3 knockout enhances OPCs' migration capacity on the ECM glycoprotein tenascin-C, while not affecting their migration on other ECM molecules. Furthermore, activation of RhoA GTPase signaling compromises migration, while inhibition of RhoA signaling promotes migration behavior.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Lingye Zhang, Anni Zhou, Shengtao Zhu, Li Min, Si Liu, Peng Li, Shutian Zhang
Summary: This review summarizes the biological functions and molecular mechanisms of ARHGAP26 in different tumors, proposes the potential clinical value of ARHGAP26 in cancer treatment, and discusses current issues that need to be addressed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Lana Buzuk, Doris Hellerschmied
Summary: The Golgi apparatus plays a crucial role in the secretory pathway of eukaryotic cells, processing proteins and organizing their transportation to other cellular compartments. It is involved in cell surface formation, cell polarity, cell-cell communication, immune signaling, DNA damage response, and mitosis. Maintaining Golgi integrity and protein homeostasis is essential, as Golgi fragmentation and dysfunction are linked to neurodegenerative diseases and certain cancers. Recent studies have revealed the importance of ubiquitin signaling in maintaining Golgi integrity and protein quality control, similar to the endoplasmic reticulum. Ubiquitination helps prevent the accumulation of toxic protein aggregates and regulates Golgi structural rearrangements in response to cellular stress.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Meilan Chen, Lu Xu, Yi Wu, Peter Soba, Chun Hu
Summary: Dendrites are specialized compartments in neurons that sense, integrate, and transfer information. Abnormal dendrite development is strongly linked to neurological disorders. The Golgi apparatus, located at the center of the secretory pathway, plays a crucial role in posttranslational modifications, sorting, transport, and signal transduction. It also forms distinct structures known as Golgi outposts in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders are still not well understood and lack a comprehensive summary.
Article
Oncology
Kathryn M. Appleton, Charuta C. Palsuledesai, Sean A. Misek, Maja Blake, Joseph Zagorski, Kathleen A. Gallo, Thomas S. Dexheimer, Richard R. Neubig
Summary: In NRAS mutant melanoma cells, activation of the Rho pathway is associated with high intrinsic resistance to the MEK inhibitor trametinib. Combining a Rho/MRTF pathway inhibitor with trametinib can synergistically reduce cell viability and induce apoptosis in resistant melanoma cells. Targeting both the Rho/MRTF pathway and MEK shows therapeutic potential in NRAS mutant melanomas.
Review
Biochemistry & Molecular Biology
Qingchun Lu, Po-Shun Wang, Ling Yang
Summary: This review focuses on highlighting Golgi-associated Rab GTPases as master regulators of autophagic flux, discussing the future research prospects in elucidating their role and mechanism in autophagy and autophagy-related diseases.
CELL AND BIOSCIENCE
(2021)
Review
Neurosciences
Eckart Foerster, Hans H. Bock, Joachim Herz, Xuejun Chai, Michael Frotscher, Shanting Zhao
EUROPEAN JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Martin C. Mueller, Matthias Osswald, Stefanie Tinnes, Ute Haeussler, Anne Jacobi, Eckart Foerster, Michael Frotscher, Carola A. Haas
EXPERIMENTAL NEUROLOGY
(2009)
Article
Cell Biology
Tina Lindhorst, Haymo Kurz, Mirjam Sibbe, Maurice Meseke, Eckart Foerster
HISTOCHEMISTRY AND CELL BIOLOGY
(2012)
Article
Cell Biology
Maurice Meseke, Ersin Cavus, Eckart Foerster
HISTOCHEMISTRY AND CELL BIOLOGY
(2013)
Article
Engineering, Biomedical
Maurice Meseke, Eckart Foerster
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2013)
Article
Neurosciences
Mirjam Sibbe, Eckart Foerster, Onur Basak, Verdon Taylor, Michael Frotscher
JOURNAL OF NEUROSCIENCE
(2009)
Article
Clinical Neurology
Elisabeth Petrasch-Parwez, Andreas Schoebel, Alia Benali, Zahra Moinfar, Eckart Foerster, Martin Bruene, Georg Juckel
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Mohammad I. K. Hamad, Abdalrahim Jbara, Obada Rabaya, Petya Petrova, Solieman Daoud, Nesrine Melliti, Maurice Meseke, David Lutz, Elisabeth Petrasch-Parwez, Jan Claudius Schwitalla, Melanie D. Mark, Stefan Herlitze, Gebhard Reiss, Joachim Herz, Eckart Foerster
Summary: Reelin plays a crucial role in controlling early network activity by modulating GABA(B)R function, affecting the excitability of the cortical network.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemical Research Methods
Mohammad I. K. Hamad, Solieman Daoud, Petya Petrova, Obada Rabaya, Abdalrahim Jbara, Nesrine Melliti, Sarah Stichmann, Gebhard Reiss, Joachim Herz, Eckart Foerster
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Developmental Biology
ST Zhao, XJ Chai, E Förster, M Frotscher
Article
Biochemistry & Molecular Biology
HH Bock, Y Jossin, PS Liu, E Förster, P May, AM Goffinet, J Herz
JOURNAL OF BIOLOGICAL CHEMISTRY
(2003)
Article
Biochemistry & Molecular Biology
L Arnaud, BA Ballif, E Förster, JA Cooper
Article
Multidisciplinary Sciences
E Förster, A Tielsch, B Saum, KH Weiss, C Johanssen, D Graus-Porta, U Müller, M Frotscher
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2002)