Sperm RNA Payload: Implications for Intergenerational Epigenetic Inheritance

tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes

(2022) Wen Zhang et al.   MOLECULAR CELL

Function and Therapeutic Implications of tRNA Derived Small RNAs

(2022) Briana Wilson et al.   Frontiers in Molecular Biosciences

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring

(2021) Ariane Lismer et al.   DEVELOPMENTAL CELL

High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq

(2021) Andrew Behrens et al.   MOLECULAR CELL

Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm

(2021) Yu H. Sun et al.   Nature Communications

Sperm microRNAs confer depression susceptibility to offspring

(2021) Yanbo Wang et al.   Science Advances

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

(2021) Junchao Shi et al.   NATURE CELL BIOLOGY

Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

(2021) Georges Raad et al.   eLife

Multigenerational epigenetic inheritance: Transmitting information across generations

(2021) Nicholas O. Burton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Single paternal dexamethasone challenge programs offspring metabolism and reveals multiple candidates in RNA-mediated inheritance

(2021) Katharina Gapp et al.   iScience

Direct Nanopore Sequencing of Individual Full Length tRNA Strands

(2021) Niki K. Thomas et al.   ACS Nano

FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development

(2021) Teresa Chioccarelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Low-bias ncRNA libraries using ordered two-template relay: Serial template jumping by a modified retroelement reverse transcriptase

(2021) Heather E. Upton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

m6A-dependent biogenesis of circular RNAs in male germ cells

(2020) Chong Tang et al.   CELL RESEARCH

Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality

(2020) Teresa Chioccarelli et al.   Journal of Clinical Medicine

Coincubation of sperm with epididymal extracellular vesicle preparations from chronic intermittent ethanol-treated mice is sufficient to impart anxiety-like and ethanol-induced behaviors to adult progeny

(2020) Gregory R. Rompala et al.   ALCOHOL

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A comprehensive overview of bull sperm-borne small non-coding RNAs and their diversity across breeds

(2020) Eli Sellem et al.   Epigenetics & Chromatin

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

(2020) Jennifer C. Chan et al.   Nature Communications

Identification of circular RNAs in porcine sperm and evaluation of their relation to sperm motility

(2020) Marta Gòdia et al.   Scientific Reports

Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring

(2020) Xiaoyan Wan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction

(2020) Emma R. James et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa

(2020) Xiaoxu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility

(2020) Pei-Hsuan Wu et al.   NATURE GENETICS

Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline

(2020) Raquel Santana da Cruz et al.   Frontiers in Nutrition

The dynamics and regulation of chromatin remodeling during spermiogenesis

(2019) Shuang-Li Hao et al.   GENE

Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring

(2019) Andrew B. Hawkey et al.   NEUROTOXICOLOGY AND TERATOLOGY

The contribution of epididymosomes to the sperm small RNA profile

(2019) Natalie A Trigg et al.   REPRODUCTION

A Regulator of Metabolic Reprogramming: MicroRNA Let-7

(2019) Shuai Jiang   Translational Oncology

Transfer of microRNAs from epididymal epithelium to equine spermatozoa

(2019) Hannah Twenter et al.   JOURNAL OF EQUINE VETERINARY SCIENCE

Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information

(2019) Upasna Sharma   Frontiers in Cell and Developmental Biology

Control of noncoding RNA production and histone levels by a 5′ tRNA fragment

(2019) Ana Boskovic et al.   GENES & DEVELOPMENT

Human sperm displays rapid responses to diet

(2019) Daniel Nätt et al.   PLOS BIOLOGY

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

(2018) Wenfei Sun et al.   NATURE MEDICINE

Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

(2018) Michael K. Skinner et al.   Epigenetics & Chromatin

Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots

(2018) Lars R. Ingerslev et al.   Clinical Epigenetics

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress

(2018) David A. Dickson et al.   Translational Psychiatry

SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs

(2018) Junchao Shi et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Transgenerational Epigenetic Inheritance

(2018) Ana Bošković et al.   Annual Review of Genetics

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma

(2018) K. Gapp et al.   MOLECULAR PSYCHIATRY

Paternal Preconception Chronic Variable Stress Confers Attenuated Ethanol Drinking Behavior Selectively to Male Offspring in a Pre-Stress Environment Dependent Manner

(2018) Gregory R. Rompala et al.   Frontiers in Behavioral Neuroscience

Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants

(2018) Deirdre M. McCarthy et al.   PLOS BIOLOGY

Generation of 2′,3′-Cyclic Phosphate-Containing RNAs as a Hidden Layer of the Transcriptome

(2018) Megumi Shigematsu et al.   Frontiers in Genetics

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

(2017) M E Wimmer et al.   MOLECULAR PSYCHIATRY

A transfer-RNA-derived small RNA regulates ribosome biogenesis

(2017) Hak Kyun Kim et al.   NATURE

Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring

(2017) Markus P Vallaster et al.   eLife

Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety

(2017) A K Short et al.   Translational Psychiatry

The roles of microRNAs in regulation of mammalian spermatogenesis

(2017) Xiaoxu Chen et al.   Journal of Animal Science and Biotechnology

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring

(2016) Ling Wu et al.   Cell Metabolism

Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice

(2016) Alexander K. Murashov et al.   FASEB JOURNAL

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

(2016) Michelle L. Holland et al.   SCIENCE

Transgenerational inheritance: Models and mechanisms of non-DNA sequence-based inheritance

(2016) E. A. Miska et al.   SCIENCE

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

(2016) Pankaj Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model

(2016) Camile Castilho Fontelles et al.   Scientific Reports

Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers

(2016) Nicole O. McPherson et al.   Scientific Reports

Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations

(2016) Jing Xue et al.   Clinical Epigenetics

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

(2016) A K Short et al.   Translational Psychiatry

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Highly sensitive sequencing reveals dynamic modifications and activities of small RNAs in mouse oocytes and early embryos

(2016) Q. Yang et al.   Science Advances

Tertiary Epimutations – A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability

(2016) John R. McCarrey et al.   PLoS One

Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome

(2016) Jackson N. Reilly et al.   Scientific Reports

The MicroRNA Signature of Mouse Spermatozoa Is Substantially Modified During Epididymal Maturation1

(2015) Brett Nixon et al.   BIOLOGY OF REPRODUCTION

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Paternal BPA exposure in early life alters Igf2 epigenetic status in sperm and induces pancreatic impairment in rat offspring

(2015) Zhenxing Mao et al.   TOXICOLOGY LETTERS

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

(2014) Adam J. Watkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Where long noncoding RNAs meet DNA methylation

(2014) Fan Lai et al.   CELL RESEARCH

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder-like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse offspring

(2014) Pitna Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation

(2014) Fei Liang et al.   NEUROPHARMACOLOGY

Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis1

(2013) Clémence Belleannée et al.   BIOLOGY OF REPRODUCTION

Chromatin remodeling by the small RNA machinery in mammalian cells

(2013) Long-Cheng Li   Epigenetics

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes

(2013) Xin Zhiguo Li et al.   MOLECULAR CELL

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

Daddy Issues: Paternal Effects on Phenotype

(2012) Oliver J. Rando   CELL

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

(2012) Emma L. Marczylo et al.   Epigenetics

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

(2012) Todd S. Macfarlan et al.   NATURE

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst

(2012) Natalie K. Binder et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring

(2012) Sonia de Assis et al.   Nature Communications

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

EGO-1, a C. elegans RdRP, Modulates Gene Expression via Production of mRNA-Templated Short Antisense RNAs

(2011) Jay M. Maniar et al.   CURRENT BIOLOGY

A survey of small RNAs in human sperm

(2011) Stephen A. Krawetz et al.   HUMAN REPRODUCTION

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

(2011) C. P. Morgan et al.   JOURNAL OF NEUROSCIENCE

Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena

(2011) Kasper L. Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

Mammalian Genomic Imprinting

(2011) M. S. Bartolomei et al.   Cold Spring Harbor Perspectives in Biology

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice

(2011) Isabelle C. Weiss et al.   Frontiers in Behavioral Neuroscience

Transfer RNA-derived fragments: origins, processing, and functions

(2011) Andrew Sobala et al.   Wiley Interdisciplinary Reviews-RNA

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Paramutation in maize: RNA mediated trans-generational gene silencing

(2010) Mario Alberto Arteaga-Vazquez et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

A Small-RNA Perspective on Gametogenesis, Fertilization, and Early Zygotic Development

(2010) Déborah Bourc’his et al.   SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Modulation of Gene Expression by Human Cytosolic tRNase ZL through 5′-Half-tRNA

(2009) Reyad A. Elbarbary et al.   PLoS One

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

(2008) Roberta Benetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing

(2007) Markus Hafner et al.   METHODS